Audit of efficacy of Coartem™ to clear plasmodium falciparum malaria parasitaemia at single forty-two day follow-up
Background: A follow-up study was undertaken to assess the efficacy of Coartem™ tablets (20 mg artemether and 120 mg lumefantrine—Novartis South Africa (Pty) Ltd) to clear plasmodium falciparum malaria parasitaemia at a single 42-day follow-up, with 42 days being chosen in order to detect early emer...
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| Language: | English |
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AOSIS
2004-07-01
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| Series: | South African Family Practice |
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| Online Access: | https://safpj.co.za/index.php/safpj/article/view/85 |
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| author | C.H. Vaughan Williams C. La Cock B.L.F Bredenkamp |
| author_facet | C.H. Vaughan Williams C. La Cock B.L.F Bredenkamp |
| author_sort | C.H. Vaughan Williams |
| collection | DOAJ |
| description | Background: A follow-up study was undertaken to assess the efficacy of Coartem™ tablets (20 mg artemether and 120 mg lumefantrine—Novartis South Africa (Pty) Ltd) to clear plasmodium falciparum malaria parasitaemia at a single 42-day follow-up, with 42 days being chosen in order to detect early emergence of resistance. The study was performed at Ndumo Clinic and Mosvold Hospital in the Ingwavuma District of KwaZulu-Natal, South Africa in January/February 2002.
Method: The study included 37 patients presenting to Ndumo Clinic and two presenting to Mosvold Hospital with uncomplicated malaria diagnosed by symptoms and a positive immunochromographic test (ICT) for plasmodium falciparum. The main outcome measures were Trophozoite counts on thick film and polymerase chain reaction parasite analysis of blood spot at day 42.
Results: Only 31 of the 37 recruited patients were confirmed to be suffering from malaria by polymerase chain reaction (PCR). Of the 31, 24 returned for follow-up. One patient had parasitaemia at day 33, but tested negative at day 42 after re-treatment with Coartem™. It was not determined whether this patient was suffering from a recrudescence or re-infection of falciparum malaria. All the other returning patients tested negative for falciparum malaria on blood film and PCR examination.
Conclusions: Coartem™ still appears to be an effective treatment for falciparum malaria. Regular assessment of its efficacy is desirable. |
| format | Article |
| id | doaj-art-342f290f4ec640bfbddb749140e9d281 |
| institution | Kabale University |
| issn | 2078-6190 2078-6204 |
| language | English |
| publishDate | 2004-07-01 |
| publisher | AOSIS |
| record_format | Article |
| series | South African Family Practice |
| spelling | doaj-art-342f290f4ec640bfbddb749140e9d2812025-08-20T04:03:18ZengAOSISSouth African Family Practice2078-61902078-62042004-07-0146610.1080/20786204.2004.1087309484Audit of efficacy of Coartem™ to clear plasmodium falciparum malaria parasitaemia at single forty-two day follow-upC.H. Vaughan Williams0C. La Cock1B.L.F Bredenkamp2Mosvold HospitalKwaZulu-Natal Laboratory Services Stationed at Department of HealthMalaria Research Programme of Medical Research CouncilBackground: A follow-up study was undertaken to assess the efficacy of Coartem™ tablets (20 mg artemether and 120 mg lumefantrine—Novartis South Africa (Pty) Ltd) to clear plasmodium falciparum malaria parasitaemia at a single 42-day follow-up, with 42 days being chosen in order to detect early emergence of resistance. The study was performed at Ndumo Clinic and Mosvold Hospital in the Ingwavuma District of KwaZulu-Natal, South Africa in January/February 2002. Method: The study included 37 patients presenting to Ndumo Clinic and two presenting to Mosvold Hospital with uncomplicated malaria diagnosed by symptoms and a positive immunochromographic test (ICT) for plasmodium falciparum. The main outcome measures were Trophozoite counts on thick film and polymerase chain reaction parasite analysis of blood spot at day 42. Results: Only 31 of the 37 recruited patients were confirmed to be suffering from malaria by polymerase chain reaction (PCR). Of the 31, 24 returned for follow-up. One patient had parasitaemia at day 33, but tested negative at day 42 after re-treatment with Coartem™. It was not determined whether this patient was suffering from a recrudescence or re-infection of falciparum malaria. All the other returning patients tested negative for falciparum malaria on blood film and PCR examination. Conclusions: Coartem™ still appears to be an effective treatment for falciparum malaria. Regular assessment of its efficacy is desirable.https://safpj.co.za/index.php/safpj/article/view/85falciparum malaria, lumefantrine, artemether |
| spellingShingle | C.H. Vaughan Williams C. La Cock B.L.F Bredenkamp Audit of efficacy of Coartem™ to clear plasmodium falciparum malaria parasitaemia at single forty-two day follow-up South African Family Practice falciparum malaria, lumefantrine, artemether |
| title | Audit of efficacy of Coartem™ to clear plasmodium falciparum malaria parasitaemia at single forty-two day follow-up |
| title_full | Audit of efficacy of Coartem™ to clear plasmodium falciparum malaria parasitaemia at single forty-two day follow-up |
| title_fullStr | Audit of efficacy of Coartem™ to clear plasmodium falciparum malaria parasitaemia at single forty-two day follow-up |
| title_full_unstemmed | Audit of efficacy of Coartem™ to clear plasmodium falciparum malaria parasitaemia at single forty-two day follow-up |
| title_short | Audit of efficacy of Coartem™ to clear plasmodium falciparum malaria parasitaemia at single forty-two day follow-up |
| title_sort | audit of efficacy of coartem™ to clear plasmodium falciparum malaria parasitaemia at single forty two day follow up |
| topic | falciparum malaria, lumefantrine, artemether |
| url | https://safpj.co.za/index.php/safpj/article/view/85 |
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