Lung autotransplantation combined with postoperative chemotherapy and immunotherapy: a three-year follow-up case report
Abstract Background Lung cancer remains a leading cause of cancer-related mortality worldwide. Autotransplantation has emerged as a potential surgical intervention in select cases, with the aim of achieving curative outcomes. This case report describes a novel approach combining lung autotransplanta...
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| Format: | Article |
| Language: | English |
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BMC
2024-10-01
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| Series: | World Journal of Surgical Oncology |
| Online Access: | https://doi.org/10.1186/s12957-024-03545-9 |
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| author | Jiang Wang Tong Li Hengxiao Lu Qiang Zhao |
| author_facet | Jiang Wang Tong Li Hengxiao Lu Qiang Zhao |
| author_sort | Jiang Wang |
| collection | DOAJ |
| description | Abstract Background Lung cancer remains a leading cause of cancer-related mortality worldwide. Autotransplantation has emerged as a potential surgical intervention in select cases, with the aim of achieving curative outcomes. This case report describes a novel approach combining lung autotransplantation with postoperative chemotherapy and immunotherapy, delineating the patient's journey over a period of three years. Case presentation We report on a 37-year-old patient with stage IIIA non-small cell lung cancer (NSCLC) who underwent lung autotransplantation. Despite the complexity of the procedure, the patient had a favorable postoperative course. Adjuvant therapy included a PD-1 inhibitor and a standard chemotherapy regimen. The patient’s follow-up involved regular clinical assessment, imaging, and functional status evaluation, demonstrating a remarkable disease-free survival at the three-year mark postoperatively. Conclusion This case highlights the potential for lung autotransplantation coupled with immunotherapy and chemotherapy to yield significant long-term survival benefits in patients with NSCLC. The favorable outcome suggests that this integrative treatment strategy warrants further investigation and may offer hope to patients with similarly advanced lung cancer. |
| format | Article |
| id | doaj-art-342eecfa25a141eaafb2a30e59f53275 |
| institution | DOAJ |
| issn | 1477-7819 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj-art-342eecfa25a141eaafb2a30e59f532752025-08-20T03:13:58ZengBMCWorld Journal of Surgical Oncology1477-78192024-10-012211610.1186/s12957-024-03545-9Lung autotransplantation combined with postoperative chemotherapy and immunotherapy: a three-year follow-up case reportJiang Wang0Tong Li1Hengxiao Lu2Qiang Zhao3Department of Thoracic Surgery, Weifang People’s Hospital, Kuiwen DistrictDepartment of Thoracic Surgery, Weifang People’s Hospital, Kuiwen DistrictDepartment of Thoracic Surgery, Weifang People’s Hospital, Kuiwen DistrictDepartment of Thoracic Surgery, Weifang People’s Hospital, Kuiwen DistrictAbstract Background Lung cancer remains a leading cause of cancer-related mortality worldwide. Autotransplantation has emerged as a potential surgical intervention in select cases, with the aim of achieving curative outcomes. This case report describes a novel approach combining lung autotransplantation with postoperative chemotherapy and immunotherapy, delineating the patient's journey over a period of three years. Case presentation We report on a 37-year-old patient with stage IIIA non-small cell lung cancer (NSCLC) who underwent lung autotransplantation. Despite the complexity of the procedure, the patient had a favorable postoperative course. Adjuvant therapy included a PD-1 inhibitor and a standard chemotherapy regimen. The patient’s follow-up involved regular clinical assessment, imaging, and functional status evaluation, demonstrating a remarkable disease-free survival at the three-year mark postoperatively. Conclusion This case highlights the potential for lung autotransplantation coupled with immunotherapy and chemotherapy to yield significant long-term survival benefits in patients with NSCLC. The favorable outcome suggests that this integrative treatment strategy warrants further investigation and may offer hope to patients with similarly advanced lung cancer.https://doi.org/10.1186/s12957-024-03545-9 |
| spellingShingle | Jiang Wang Tong Li Hengxiao Lu Qiang Zhao Lung autotransplantation combined with postoperative chemotherapy and immunotherapy: a three-year follow-up case report World Journal of Surgical Oncology |
| title | Lung autotransplantation combined with postoperative chemotherapy and immunotherapy: a three-year follow-up case report |
| title_full | Lung autotransplantation combined with postoperative chemotherapy and immunotherapy: a three-year follow-up case report |
| title_fullStr | Lung autotransplantation combined with postoperative chemotherapy and immunotherapy: a three-year follow-up case report |
| title_full_unstemmed | Lung autotransplantation combined with postoperative chemotherapy and immunotherapy: a three-year follow-up case report |
| title_short | Lung autotransplantation combined with postoperative chemotherapy and immunotherapy: a three-year follow-up case report |
| title_sort | lung autotransplantation combined with postoperative chemotherapy and immunotherapy a three year follow up case report |
| url | https://doi.org/10.1186/s12957-024-03545-9 |
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