Antibiotic resistance genes in the animal manure-amended soil-plant system: Occurrence, transmission, bacterial hosts, and human health risks
Animal manure is a hotspot of antibiotic resistance genes (ARGs). Manure fertilization, a globally prevalent agricultural practice, poses potential risks to food safety and human health by serving as a significant pathway for resistomes to enter the soil–plant system. In this review, the occurrence...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325012357 |
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| author | Bingshen Liu Zenan Shen Qian Zhou Jiayun Ren Haiqing Wang Daoyong Zhang Xiangliang Pan |
| author_facet | Bingshen Liu Zenan Shen Qian Zhou Jiayun Ren Haiqing Wang Daoyong Zhang Xiangliang Pan |
| author_sort | Bingshen Liu |
| collection | DOAJ |
| description | Animal manure is a hotspot of antibiotic resistance genes (ARGs). Manure fertilization, a globally prevalent agricultural practice, poses potential risks to food safety and human health by serving as a significant pathway for resistomes to enter the soil–plant system. In this review, the occurrence and variability of ARGs in animal manure are introduced, and the impacts of manure application on ARG profiles in soils are assessed. Furthermore, a detailed summary is provided on the transmission pathways of resistomes from manure-amended soils to different plant compartments, including the endosphere and phyllosphere. Considering the critical role of ARG hosts in human health risk assessment, we provide a comprehensive summary of their taxonomic diversity as detected through culture–independent approaches. In addition, the research progress on human exposure risks associated with ARGs is discussed, including exposure pathways and indicators for risk assessment. Finally, this review outlines future research directions, including the development of mitigation strategies (focusing on attenuation mechanisms and transmission pathways of ARGs), the quantification of contributions from various ARG transmission pathways, and the systematic identification of ARG hosts. This review familiarizes readers with the current research status of ARGs in the manure-amended soil-plant system, highlighting the human exposure risks associated with ARG transmission across the manure-soil-plant continuum. |
| format | Article |
| id | doaj-art-342a9290a6714812a325d0725a061df2 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-342a9290a6714812a325d0725a061df22025-08-20T03:47:06ZengElsevierEcotoxicology and Environmental Safety0147-65132025-09-0130311889010.1016/j.ecoenv.2025.118890Antibiotic resistance genes in the animal manure-amended soil-plant system: Occurrence, transmission, bacterial hosts, and human health risksBingshen Liu0Zenan Shen1Qian Zhou2Jiayun Ren3Haiqing Wang4Daoyong Zhang5Xiangliang Pan6Shandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta, Shandong University of Aeronautics, Binzhou, Shandong 256603, China; Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China; Correspondence to: Shandong University of Aeronautics, Binzhou, Shandong 256603, China.Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, ChinaKey Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, ChinaShandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta, Shandong University of Aeronautics, Binzhou, Shandong 256603, ChinaShandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta, Shandong University of Aeronautics, Binzhou, Shandong 256603, ChinaKey Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, ChinaKey Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China; Corresponding author.Animal manure is a hotspot of antibiotic resistance genes (ARGs). Manure fertilization, a globally prevalent agricultural practice, poses potential risks to food safety and human health by serving as a significant pathway for resistomes to enter the soil–plant system. In this review, the occurrence and variability of ARGs in animal manure are introduced, and the impacts of manure application on ARG profiles in soils are assessed. Furthermore, a detailed summary is provided on the transmission pathways of resistomes from manure-amended soils to different plant compartments, including the endosphere and phyllosphere. Considering the critical role of ARG hosts in human health risk assessment, we provide a comprehensive summary of their taxonomic diversity as detected through culture–independent approaches. In addition, the research progress on human exposure risks associated with ARGs is discussed, including exposure pathways and indicators for risk assessment. Finally, this review outlines future research directions, including the development of mitigation strategies (focusing on attenuation mechanisms and transmission pathways of ARGs), the quantification of contributions from various ARG transmission pathways, and the systematic identification of ARG hosts. This review familiarizes readers with the current research status of ARGs in the manure-amended soil-plant system, highlighting the human exposure risks associated with ARG transmission across the manure-soil-plant continuum.http://www.sciencedirect.com/science/article/pii/S0147651325012357Antibiotic resistance genesManure fertilizationPlant endosphereTransmission pathwaysHost identification |
| spellingShingle | Bingshen Liu Zenan Shen Qian Zhou Jiayun Ren Haiqing Wang Daoyong Zhang Xiangliang Pan Antibiotic resistance genes in the animal manure-amended soil-plant system: Occurrence, transmission, bacterial hosts, and human health risks Ecotoxicology and Environmental Safety Antibiotic resistance genes Manure fertilization Plant endosphere Transmission pathways Host identification |
| title | Antibiotic resistance genes in the animal manure-amended soil-plant system: Occurrence, transmission, bacterial hosts, and human health risks |
| title_full | Antibiotic resistance genes in the animal manure-amended soil-plant system: Occurrence, transmission, bacterial hosts, and human health risks |
| title_fullStr | Antibiotic resistance genes in the animal manure-amended soil-plant system: Occurrence, transmission, bacterial hosts, and human health risks |
| title_full_unstemmed | Antibiotic resistance genes in the animal manure-amended soil-plant system: Occurrence, transmission, bacterial hosts, and human health risks |
| title_short | Antibiotic resistance genes in the animal manure-amended soil-plant system: Occurrence, transmission, bacterial hosts, and human health risks |
| title_sort | antibiotic resistance genes in the animal manure amended soil plant system occurrence transmission bacterial hosts and human health risks |
| topic | Antibiotic resistance genes Manure fertilization Plant endosphere Transmission pathways Host identification |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325012357 |
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