Sinonasal small-cell carcinoma combined concurrently with small-cell lung carcinoma: case report and literature review
Sinonasal small-cell neuroendocrine carcinoma (SCNEC) is an uncommon malignant epithelial neuroendocrine tumor in the sinonasal cavity that often presents in isolation and rarely occurs in synchronous fashion with small-cell lung carcinoma (SCLC). Here, we present a case of a 65-year-old man diagnos...
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| Format: | Article |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1457907/full |
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| author | Rencui Quan Rencui Quan Ling Han Shihai Wu Xianming Li |
| author_facet | Rencui Quan Rencui Quan Ling Han Shihai Wu Xianming Li |
| author_sort | Rencui Quan |
| collection | DOAJ |
| description | Sinonasal small-cell neuroendocrine carcinoma (SCNEC) is an uncommon malignant epithelial neuroendocrine tumor in the sinonasal cavity that often presents in isolation and rarely occurs in synchronous fashion with small-cell lung carcinoma (SCLC). Here, we present a case of a 65-year-old man diagnosed with SCNEC concurrently combined with SCLC. He received first-line platinum-doublet chemotherapy combined with durvalumab, followed by radiotherapy to thoracic as well as head and neck regions. The follow-up computed tomography and magnetic resonance imaging showed a complete response according to Response Evaluation Criteria in Solid Tumors criteria until 9 June 2024. This case highlights the need for accurate diagnostic characterization of primary lesions and the need to formalize treatment paradigms using chemotherapy, radiation therapy, immunotherapy with immune checkpoint inhibitors, and targeted prophylactic cranial irradiation. |
| format | Article |
| id | doaj-art-342a0bbb355341bba3b2fd1308d7d87e |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-342a0bbb355341bba3b2fd1308d7d87e2025-01-29T06:46:11ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011610.3389/fimmu.2025.14579071457907Sinonasal small-cell carcinoma combined concurrently with small-cell lung carcinoma: case report and literature reviewRencui Quan0Rencui Quan1Ling Han2Shihai Wu3Xianming Li4Jinan University, Guangzhou, ChinaDepartment of Radiation Oncology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, ChinaDepartment of ENT, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, ChinaDepartment of Radiation Oncology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, ChinaDepartment of Radiation Oncology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, ChinaSinonasal small-cell neuroendocrine carcinoma (SCNEC) is an uncommon malignant epithelial neuroendocrine tumor in the sinonasal cavity that often presents in isolation and rarely occurs in synchronous fashion with small-cell lung carcinoma (SCLC). Here, we present a case of a 65-year-old man diagnosed with SCNEC concurrently combined with SCLC. He received first-line platinum-doublet chemotherapy combined with durvalumab, followed by radiotherapy to thoracic as well as head and neck regions. The follow-up computed tomography and magnetic resonance imaging showed a complete response according to Response Evaluation Criteria in Solid Tumors criteria until 9 June 2024. This case highlights the need for accurate diagnostic characterization of primary lesions and the need to formalize treatment paradigms using chemotherapy, radiation therapy, immunotherapy with immune checkpoint inhibitors, and targeted prophylactic cranial irradiation.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1457907/fullsinonasal small cell neuroendocrine carcinomasmall cell lung carcinoma (SCLC)immune checkpoint inhibitorsPD-L1maintenance treatment |
| spellingShingle | Rencui Quan Rencui Quan Ling Han Shihai Wu Xianming Li Sinonasal small-cell carcinoma combined concurrently with small-cell lung carcinoma: case report and literature review Frontiers in Immunology sinonasal small cell neuroendocrine carcinoma small cell lung carcinoma (SCLC) immune checkpoint inhibitors PD-L1 maintenance treatment |
| title | Sinonasal small-cell carcinoma combined concurrently with small-cell lung carcinoma: case report and literature review |
| title_full | Sinonasal small-cell carcinoma combined concurrently with small-cell lung carcinoma: case report and literature review |
| title_fullStr | Sinonasal small-cell carcinoma combined concurrently with small-cell lung carcinoma: case report and literature review |
| title_full_unstemmed | Sinonasal small-cell carcinoma combined concurrently with small-cell lung carcinoma: case report and literature review |
| title_short | Sinonasal small-cell carcinoma combined concurrently with small-cell lung carcinoma: case report and literature review |
| title_sort | sinonasal small cell carcinoma combined concurrently with small cell lung carcinoma case report and literature review |
| topic | sinonasal small cell neuroendocrine carcinoma small cell lung carcinoma (SCLC) immune checkpoint inhibitors PD-L1 maintenance treatment |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1457907/full |
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