LITERATURE REVIEW: SENSITIVITY AND SPECIFICITY OF VDRL AND RPR AS SCREENING TESTS OF SYPHILIS IN PREGNANT WOMEN
Early detection of syphilis, especially during pregnancy, is important to prevent comorbidities for the mother and the baby. This study aims to determine whether VDRL is more sensitive and specific than RPR as a diagnostic screening test for syphilis infection in pregnant women. Literature searches...
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| Format: | Article |
| Language: | English |
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Universitas Airlangga
2021-10-01
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| Series: | Journal of Community Medicine and Public Health Research |
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| Online Access: | https://e-journal.unair.ac.id/JCMPHR/article/view/26334 |
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| author | Tamara Audrey Kadarusman Sacharissa Zerlina Tsarwah Thirafi Niki Kusuma Bangsa Rufina Adelia Widyatama Lutfi Dewanda Nugroho Prima Ardiansah Surya Pudji Lestari |
| author_facet | Tamara Audrey Kadarusman Sacharissa Zerlina Tsarwah Thirafi Niki Kusuma Bangsa Rufina Adelia Widyatama Lutfi Dewanda Nugroho Prima Ardiansah Surya Pudji Lestari |
| author_sort | Tamara Audrey Kadarusman |
| collection | DOAJ |
| description | Early detection of syphilis, especially during pregnancy, is important to prevent comorbidities for the mother and the baby. This study aims to determine whether VDRL is more sensitive and specific than RPR as a diagnostic screening test for syphilis infection in pregnant women. Literature searches for relevant articles were conducted in PubMed, Cochrane, and Proquest using the keywords "VDRL AND RPR AND pregnancy AND syphilis". From the search results, we found 7 articles in Pubmed, 2.290 articles in Proquest, and no relevant articles were found in Cochrane. Title and abstracts were screened for their conformity with the case and clinical questions that had been made. Selected articles were then critically appraised. The results of the study in selected articles indicated that VDRL and RPR showed a false positives rate of 10.5% and 9.6%, respectively. The sensitivity and specificity of VDRL were 71.6% and 89.5%, and those of RPR were 73.5% and 90.5%. VDRL and RPR have a moderate agreement with the TPHA (kappa = 0.6). From these studies it can be concluded that VDRL is not more sensitive and specific than RPR, implying that RPR is a better diagnostic screening test for syphilis infection in pregnant women than VDRL. |
| format | Article |
| id | doaj-art-3429f39ca3764fb9b91cd460b8802f2f |
| institution | Kabale University |
| issn | 2723-035X |
| language | English |
| publishDate | 2021-10-01 |
| publisher | Universitas Airlangga |
| record_format | Article |
| series | Journal of Community Medicine and Public Health Research |
| spelling | doaj-art-3429f39ca3764fb9b91cd460b8802f2f2025-08-20T04:01:01ZengUniversitas AirlanggaJournal of Community Medicine and Public Health Research2723-035X2021-10-0122767910.20473/jcmphr.v2i2.2633421539LITERATURE REVIEW: SENSITIVITY AND SPECIFICITY OF VDRL AND RPR AS SCREENING TESTS OF SYPHILIS IN PREGNANT WOMENTamara Audrey Kadarusman0Sacharissa Zerlina Tsarwah Thirafi1https://orcid.org/0000-0001-5852-3443Niki Kusuma Bangsa2https://orcid.org/0000-0001-6567-7061Rufina Adelia Widyatama3https://orcid.org/0000-0002-0449-2925Lutfi Dewanda Nugroho4https://orcid.org/0000-0002-6056-2617Prima Ardiansah Surya5https://orcid.org/0000-0002-6619-7657Pudji Lestari6https://orcid.org/0000-0003-4725-4676Medical Student, Faculty of Medicine, Universitas Airlangga, SurabayaMedical Student, Faculty of Medicine, Universitas Airlangga, SurabayaMedical Student, Faculty of Medicine, Universitas Airlangga, SurabayaMedical Student, Faculty of Medicine, Universitas Airlangga, SurabayaMedical Student, Faculty of Medicine, Universitas Airlangga, SurabayaMedical Student, Faculty of Medicine, Universitas Airlangga, SurabayaDepartment of Public Health-Preventive Medicine, Faculty of Medicine, Universitas Airlangga, IndonesiaEarly detection of syphilis, especially during pregnancy, is important to prevent comorbidities for the mother and the baby. This study aims to determine whether VDRL is more sensitive and specific than RPR as a diagnostic screening test for syphilis infection in pregnant women. Literature searches for relevant articles were conducted in PubMed, Cochrane, and Proquest using the keywords "VDRL AND RPR AND pregnancy AND syphilis". From the search results, we found 7 articles in Pubmed, 2.290 articles in Proquest, and no relevant articles were found in Cochrane. Title and abstracts were screened for their conformity with the case and clinical questions that had been made. Selected articles were then critically appraised. The results of the study in selected articles indicated that VDRL and RPR showed a false positives rate of 10.5% and 9.6%, respectively. The sensitivity and specificity of VDRL were 71.6% and 89.5%, and those of RPR were 73.5% and 90.5%. VDRL and RPR have a moderate agreement with the TPHA (kappa = 0.6). From these studies it can be concluded that VDRL is not more sensitive and specific than RPR, implying that RPR is a better diagnostic screening test for syphilis infection in pregnant women than VDRL.https://e-journal.unair.ac.id/JCMPHR/article/view/26334evidence-based case reportvdrlrprsyphilisscreeningcommunicable diseasematernal health |
| spellingShingle | Tamara Audrey Kadarusman Sacharissa Zerlina Tsarwah Thirafi Niki Kusuma Bangsa Rufina Adelia Widyatama Lutfi Dewanda Nugroho Prima Ardiansah Surya Pudji Lestari LITERATURE REVIEW: SENSITIVITY AND SPECIFICITY OF VDRL AND RPR AS SCREENING TESTS OF SYPHILIS IN PREGNANT WOMEN Journal of Community Medicine and Public Health Research evidence-based case report vdrl rpr syphilis screening communicable disease maternal health |
| title | LITERATURE REVIEW: SENSITIVITY AND SPECIFICITY OF VDRL AND RPR AS SCREENING TESTS OF SYPHILIS IN PREGNANT WOMEN |
| title_full | LITERATURE REVIEW: SENSITIVITY AND SPECIFICITY OF VDRL AND RPR AS SCREENING TESTS OF SYPHILIS IN PREGNANT WOMEN |
| title_fullStr | LITERATURE REVIEW: SENSITIVITY AND SPECIFICITY OF VDRL AND RPR AS SCREENING TESTS OF SYPHILIS IN PREGNANT WOMEN |
| title_full_unstemmed | LITERATURE REVIEW: SENSITIVITY AND SPECIFICITY OF VDRL AND RPR AS SCREENING TESTS OF SYPHILIS IN PREGNANT WOMEN |
| title_short | LITERATURE REVIEW: SENSITIVITY AND SPECIFICITY OF VDRL AND RPR AS SCREENING TESTS OF SYPHILIS IN PREGNANT WOMEN |
| title_sort | literature review sensitivity and specificity of vdrl and rpr as screening tests of syphilis in pregnant women |
| topic | evidence-based case report vdrl rpr syphilis screening communicable disease maternal health |
| url | https://e-journal.unair.ac.id/JCMPHR/article/view/26334 |
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