Exploring BMI's mediating influence on cardiovascular risk correlations with the triglyceride-glucose index: using NHANES and CHARLS cohorts
ObjectiveThis investigation employed population-based datasets to elucidate the pathophysiological interplay between triglyceride-glucose index (TyG) and incident cardiovascular disease (CVD), and quantify the extent to which body mass index (BMI) operates as a biological mediator within this associ...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1593413/full |
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| author | Yimeng Jia Shuo Zhang Junjie Liu Junjie Liu |
| author_facet | Yimeng Jia Shuo Zhang Junjie Liu Junjie Liu |
| author_sort | Yimeng Jia |
| collection | DOAJ |
| description | ObjectiveThis investigation employed population-based datasets to elucidate the pathophysiological interplay between triglyceride-glucose index (TyG) and incident cardiovascular disease (CVD), and quantify the extent to which body mass index (BMI) operates as a biological mediator within this association, utilizing a dual-cohort analytical framework.MethodsIn this study, 17,976 Americans from the NHANES (1999–2020) and 6,218 Chinese from the CHARLS (2011–2020) were included. To investigate the intricate link between the TyG index, BMI and CVD, researchers employed weighted multiple logistic regression, linear regression, restricted cubic spline (RCS) analysis, mediation analysis, and subgroup analysis.ResultsAmong the study population, 1,895 Americans and 1,798 Chinese were diagnosed with cardiovascular disease (CVD). The regression analysis indicated that individuals in the higher quartile of the TyG index had a significantly greater risk of developing CVD (NHANES: P < 0.01, 95% CI: 1.11–1.78; CHARLS: P < 0.001, 95% CI: 1.37–1.89). In both surveys, participants with elevated TyG indices and BMI levels exhibited the highest incidence of CVD. The TyG index significantly affected CVD in both the NHANES and CHARLS cohorts. The total effect in the NHANES cohort was 1.438 × 10−3 (P < 0.001), and in the CHARLS cohort, it was 0.007 (P < 0.001).ConclusionsIn this study, two independent cross-sectional cohort studies demonstrated significant positive correlations among TyG, BMI, and CVD. Multivariate analyses identified BMI as a partial mediator in the TyG-CVD pathway, with robust effect magnitudes remaining stable after controlling for age, sex, and other confounders. |
| format | Article |
| id | doaj-art-34281111a8634d3fae80e65b6f14e266 |
| institution | OA Journals |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-34281111a8634d3fae80e65b6f14e2662025-08-20T02:33:00ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-06-011210.3389/fcvm.2025.15934131593413Exploring BMI's mediating influence on cardiovascular risk correlations with the triglyceride-glucose index: using NHANES and CHARLS cohortsYimeng Jia0Shuo Zhang1Junjie Liu2Junjie Liu3College of Clinical Medicine, North China University of Science and Technology, Tangshan, ChinaCollege of Clinical Medicine, North China University of Science and Technology, Tangshan, ChinaCollege of Clinical Medicine, North China University of Science and Technology, Tangshan, ChinaDepartment of Critical Care Medicine, Affiliated Hospital of North China University of Science and Technology, Tangshan, ChinaObjectiveThis investigation employed population-based datasets to elucidate the pathophysiological interplay between triglyceride-glucose index (TyG) and incident cardiovascular disease (CVD), and quantify the extent to which body mass index (BMI) operates as a biological mediator within this association, utilizing a dual-cohort analytical framework.MethodsIn this study, 17,976 Americans from the NHANES (1999–2020) and 6,218 Chinese from the CHARLS (2011–2020) were included. To investigate the intricate link between the TyG index, BMI and CVD, researchers employed weighted multiple logistic regression, linear regression, restricted cubic spline (RCS) analysis, mediation analysis, and subgroup analysis.ResultsAmong the study population, 1,895 Americans and 1,798 Chinese were diagnosed with cardiovascular disease (CVD). The regression analysis indicated that individuals in the higher quartile of the TyG index had a significantly greater risk of developing CVD (NHANES: P < 0.01, 95% CI: 1.11–1.78; CHARLS: P < 0.001, 95% CI: 1.37–1.89). In both surveys, participants with elevated TyG indices and BMI levels exhibited the highest incidence of CVD. The TyG index significantly affected CVD in both the NHANES and CHARLS cohorts. The total effect in the NHANES cohort was 1.438 × 10−3 (P < 0.001), and in the CHARLS cohort, it was 0.007 (P < 0.001).ConclusionsIn this study, two independent cross-sectional cohort studies demonstrated significant positive correlations among TyG, BMI, and CVD. Multivariate analyses identified BMI as a partial mediator in the TyG-CVD pathway, with robust effect magnitudes remaining stable after controlling for age, sex, and other confounders.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1593413/fullcardiovascular diseasetriglyceride-glucose indexbody mass indexmediation analysisNHANESCHARLS |
| spellingShingle | Yimeng Jia Shuo Zhang Junjie Liu Junjie Liu Exploring BMI's mediating influence on cardiovascular risk correlations with the triglyceride-glucose index: using NHANES and CHARLS cohorts Frontiers in Cardiovascular Medicine cardiovascular disease triglyceride-glucose index body mass index mediation analysis NHANES CHARLS |
| title | Exploring BMI's mediating influence on cardiovascular risk correlations with the triglyceride-glucose index: using NHANES and CHARLS cohorts |
| title_full | Exploring BMI's mediating influence on cardiovascular risk correlations with the triglyceride-glucose index: using NHANES and CHARLS cohorts |
| title_fullStr | Exploring BMI's mediating influence on cardiovascular risk correlations with the triglyceride-glucose index: using NHANES and CHARLS cohorts |
| title_full_unstemmed | Exploring BMI's mediating influence on cardiovascular risk correlations with the triglyceride-glucose index: using NHANES and CHARLS cohorts |
| title_short | Exploring BMI's mediating influence on cardiovascular risk correlations with the triglyceride-glucose index: using NHANES and CHARLS cohorts |
| title_sort | exploring bmi s mediating influence on cardiovascular risk correlations with the triglyceride glucose index using nhanes and charls cohorts |
| topic | cardiovascular disease triglyceride-glucose index body mass index mediation analysis NHANES CHARLS |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1593413/full |
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