Synthesis and Anti Cancer Activity of Pyrido[2,3-c]Pyridazine Derivatives
Cancer is not just one disease, but a large group of almost one hundred diseases. Its two main characteristics are uncontrolled growth of the cells in the human body and the ability of these cells to migrate from the original site and spread to distant sites. If the spread is not controlled, cancer...
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| Format: | Article |
| Language: | English |
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University of Tehran
2009-12-01
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| Series: | Journal of Sciences, Islamic Republic of Iran |
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| Online Access: | https://jsciences.ut.ac.ir/article_20129_947c4deef1435a821fed07e124234a04.pdf |
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| _version_ | 1849714802283249664 |
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| author | V. Kumar |
| author_facet | V. Kumar |
| author_sort | V. Kumar |
| collection | DOAJ |
| description | Cancer is not just one disease, but a large group of almost one hundred diseases. Its two main characteristics are uncontrolled growth of the cells in the human body and the ability of these cells to migrate from the original site and spread to distant sites. If the spread is not controlled, cancer can result in death. There has been continuous progress in the development of therapy for cancer. The successful treatment of cancer still remains a challenge. A new series of pyrido[2,3-c]pyridazine derivatives (8-14) were synthesized and screened for their anticancer activity. Amongst them few of the compounds have exhibited promising cytotoxicity along with good safety index. These compounds could be of use in designing new anti-cancer agents. |
| format | Article |
| id | doaj-art-342475437535471a8eeebc42b4fa0d56 |
| institution | DOAJ |
| issn | 1016-1104 2345-6914 |
| language | English |
| publishDate | 2009-12-01 |
| publisher | University of Tehran |
| record_format | Article |
| series | Journal of Sciences, Islamic Republic of Iran |
| spelling | doaj-art-342475437535471a8eeebc42b4fa0d562025-08-20T03:13:36ZengUniversity of TehranJournal of Sciences, Islamic Republic of Iran1016-11042345-69142009-12-0120420129Synthesis and Anti Cancer Activity of Pyrido[2,3-c]Pyridazine DerivativesV. KumarCancer is not just one disease, but a large group of almost one hundred diseases. Its two main characteristics are uncontrolled growth of the cells in the human body and the ability of these cells to migrate from the original site and spread to distant sites. If the spread is not controlled, cancer can result in death. There has been continuous progress in the development of therapy for cancer. The successful treatment of cancer still remains a challenge. A new series of pyrido[2,3-c]pyridazine derivatives (8-14) were synthesized and screened for their anticancer activity. Amongst them few of the compounds have exhibited promising cytotoxicity along with good safety index. These compounds could be of use in designing new anti-cancer agents.https://jsciences.ut.ac.ir/article_20129_947c4deef1435a821fed07e124234a04.pdfanti cancercytotoxicpyrido[2-3-c]pyridazine |
| spellingShingle | V. Kumar Synthesis and Anti Cancer Activity of Pyrido[2,3-c]Pyridazine Derivatives Journal of Sciences, Islamic Republic of Iran anti cancer cytotoxic pyrido[2-3-c]pyridazine |
| title | Synthesis and Anti Cancer Activity of Pyrido[2,3-c]Pyridazine Derivatives |
| title_full | Synthesis and Anti Cancer Activity of Pyrido[2,3-c]Pyridazine Derivatives |
| title_fullStr | Synthesis and Anti Cancer Activity of Pyrido[2,3-c]Pyridazine Derivatives |
| title_full_unstemmed | Synthesis and Anti Cancer Activity of Pyrido[2,3-c]Pyridazine Derivatives |
| title_short | Synthesis and Anti Cancer Activity of Pyrido[2,3-c]Pyridazine Derivatives |
| title_sort | synthesis and anti cancer activity of pyrido 2 3 c pyridazine derivatives |
| topic | anti cancer cytotoxic pyrido[2-3-c]pyridazine |
| url | https://jsciences.ut.ac.ir/article_20129_947c4deef1435a821fed07e124234a04.pdf |
| work_keys_str_mv | AT vkumar synthesisandanticanceractivityofpyrido23cpyridazinederivatives |