POU5F1 bridges Hedgehog signaling and epithelial remodeling in COPD

POU5F1 bridges Hedgehog signaling and epithelial remodeling in COPD

Airway epithelium remodeling is a hallmark of chronic obstructive pulmonary disease (COPD) pathogenesis. Hedgehog signaling is activated during airway epithelial repair to warrant proliferation and during cell differentiation to establish a fully functional epithelium with optimal mucociliary cleara...

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Main Authors: Laure M. G. Petit, Randa Belgacemi, Pauline Mulette, Audrey Brisebarre, Lynda Saber Cherif, Maëva A. Devilliers, Sarah Hatoum, Julien Ancel, Gonzague Delepine, Anne Durlach, Myriam Polette, Gaëtan Deslée, Jeanne-Marie Perotin, Valérian Dormoy
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Hedgehog
COPD
airways
epithelial cells
Pou5f1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1566251/full
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