POU5F1 bridges Hedgehog signaling and epithelial remodeling in COPD

POU5F1 bridges Hedgehog signaling and epithelial remodeling in COPD

Airway epithelium remodeling is a hallmark of chronic obstructive pulmonary disease (COPD) pathogenesis. Hedgehog signaling is activated during airway epithelial repair to warrant proliferation and during cell differentiation to establish a fully functional epithelium with optimal mucociliary cleara...

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Main Authors: Laure M. G. Petit, Randa Belgacemi, Pauline Mulette, Audrey Brisebarre, Lynda Saber Cherif, Maëva A. Devilliers, Sarah Hatoum, Julien Ancel, Gonzague Delepine, Anne Durlach, Myriam Polette, Gaëtan Deslée, Jeanne-Marie Perotin, Valérian Dormoy
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Hedgehog
COPD
airways
epithelial cells
Pou5f1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1566251/full
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Summary:Airway epithelium remodeling is a hallmark of chronic obstructive pulmonary disease (COPD) pathogenesis. Hedgehog signaling is activated during airway epithelial repair to warrant proliferation and during cell differentiation to establish a fully functional epithelium with optimal mucociliary clearance. Consequently, it was found to be altered in COPD patients. Using transcriptomic analysis on air–liquid interface airway epithelial cells during differentiation upon Hedgehog pathway inhibition, we highlighted potential regulators of COPD-associated epithelial remodeling. Furthermore, the alteration of POU5F1 (OCT3/4) was validated in COPD airway epithelial cells and lung tissues. Although further investigations are required, these findings uncovered essential clues tethering respiratory epithelial cell plasticity and Hedgehog signaling.
ISSN:2296-634X

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