Renal Involvement of CD20-Negative Intravascular Large B Cell Lymphoma with Neurological Manifestations

The involvement of hematological tumors such as lymphoma in the kidneys is a well-recognized phenomenon. Some of the distinct reported pathological processes resulting in kidney dysfunction include minimal change disease, lymphocytic invasion of the parenchyma, immune complex disposition, immunotact...

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Main Authors: Faten Aqeel, Serena M. Bagnasco, Duvuru Geetha
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Case Reports in Nephrology
Online Access:http://dx.doi.org/10.1155/2022/8613965
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author Faten Aqeel
Serena M. Bagnasco
Duvuru Geetha
author_facet Faten Aqeel
Serena M. Bagnasco
Duvuru Geetha
author_sort Faten Aqeel
collection DOAJ
description The involvement of hematological tumors such as lymphoma in the kidneys is a well-recognized phenomenon. Some of the distinct reported pathological processes resulting in kidney dysfunction include minimal change disease, lymphocytic invasion of the parenchyma, immune complex disposition, immunotactoid glomerulopathy, membranous glomerulopathy, and acute tubular injury. We report a rare case of CD20-negative intravascular lymphoma found on a kidney biopsy in a male with primary angiitis of the central nervous system (CNS) who presented with acute kidney injury and proteinuria. After the initiation of rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone (R-CHOP), kidney function improved and proteinuria resolved.
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series Case Reports in Nephrology
spelling doaj-art-341f14fca41d40b9a5060d42dad7fffe2025-08-20T02:24:17ZengWileyCase Reports in Nephrology2090-665X2022-01-01202210.1155/2022/8613965Renal Involvement of CD20-Negative Intravascular Large B Cell Lymphoma with Neurological ManifestationsFaten Aqeel0Serena M. Bagnasco1Duvuru Geetha2Division of NephrologyDepartment of PathologyDivision of NephrologyThe involvement of hematological tumors such as lymphoma in the kidneys is a well-recognized phenomenon. Some of the distinct reported pathological processes resulting in kidney dysfunction include minimal change disease, lymphocytic invasion of the parenchyma, immune complex disposition, immunotactoid glomerulopathy, membranous glomerulopathy, and acute tubular injury. We report a rare case of CD20-negative intravascular lymphoma found on a kidney biopsy in a male with primary angiitis of the central nervous system (CNS) who presented with acute kidney injury and proteinuria. After the initiation of rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone (R-CHOP), kidney function improved and proteinuria resolved.http://dx.doi.org/10.1155/2022/8613965
spellingShingle Faten Aqeel
Serena M. Bagnasco
Duvuru Geetha
Renal Involvement of CD20-Negative Intravascular Large B Cell Lymphoma with Neurological Manifestations
Case Reports in Nephrology
title Renal Involvement of CD20-Negative Intravascular Large B Cell Lymphoma with Neurological Manifestations
title_full Renal Involvement of CD20-Negative Intravascular Large B Cell Lymphoma with Neurological Manifestations
title_fullStr Renal Involvement of CD20-Negative Intravascular Large B Cell Lymphoma with Neurological Manifestations
title_full_unstemmed Renal Involvement of CD20-Negative Intravascular Large B Cell Lymphoma with Neurological Manifestations
title_short Renal Involvement of CD20-Negative Intravascular Large B Cell Lymphoma with Neurological Manifestations
title_sort renal involvement of cd20 negative intravascular large b cell lymphoma with neurological manifestations
url http://dx.doi.org/10.1155/2022/8613965
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AT serenambagnasco renalinvolvementofcd20negativeintravascularlargebcelllymphomawithneurologicalmanifestations
AT duvurugeetha renalinvolvementofcd20negativeintravascularlargebcelllymphomawithneurologicalmanifestations