The Association between Serum Cytokines and Damage to Large and Small Nerve Fibers in Diabetic Peripheral Neuropathy
Diabetic peripheral neuropathy (DPN) is a frequent complication of type 2 diabetes mellitus (DM) and may involve small and large peripheral nerve fibers. Recent evidence suggests a role of cytokines in DPN. The paper is aimed at exploring whether the serum concentration of cytokines is associated wi...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/547834 |
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| author | Francesca Magrinelli Chiara Briani Marcello Romano Susanna Ruggero Elisabetta Toffanin Giuseppa Triolo George Chummar Peter Marialuigia Praitano Matteo Francesco Lauriola Giampietro Zanette Stefano Tamburin |
| author_facet | Francesca Magrinelli Chiara Briani Marcello Romano Susanna Ruggero Elisabetta Toffanin Giuseppa Triolo George Chummar Peter Marialuigia Praitano Matteo Francesco Lauriola Giampietro Zanette Stefano Tamburin |
| author_sort | Francesca Magrinelli |
| collection | DOAJ |
| description | Diabetic peripheral neuropathy (DPN) is a frequent complication of type 2 diabetes mellitus (DM) and may involve small and large peripheral nerve fibers. Recent evidence suggests a role of cytokines in DPN. The paper is aimed at exploring whether the serum concentration of cytokines is associated with small and large nerve fiber function and with neuropathic pain (NP). We recruited a group of 32 type 2 DM patients who underwent serum cytokines (TNF-α, IL-2, IL-4, IL-6, and IL-10) dosage as well as electrodiagnostic and quantitative sensory testing (QST) assessment to explore damage to large and small nerve fibers. Raised serum levels of IL-6 and IL-10 correlated with markers of large nerve fiber sensory and motor axonal damage. Raised IL-10 serum level was associated with signs of motor nerve demyelination. No differences were found in pain characteristics and electrodiagnostic and QST markers of small nerve fiber function in relation to cytokines serum levels. IL-6 and IL-10 serum levels were associated with large nerve fiber damage but not to small fibers function or NP. IL-6 and IL-10 cytokines might play a role in the pathogenesis of nerve fiber damage or represent a compensatory or neuroprotective mechanism. |
| format | Article |
| id | doaj-art-341cef88f55245e9a2bf33c5694f16d6 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-341cef88f55245e9a2bf33c5694f16d62025-02-03T01:22:17ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/547834547834The Association between Serum Cytokines and Damage to Large and Small Nerve Fibers in Diabetic Peripheral NeuropathyFrancesca Magrinelli0Chiara Briani1Marcello Romano2Susanna Ruggero3Elisabetta Toffanin4Giuseppa Triolo5George Chummar Peter6Marialuigia Praitano7Matteo Francesco Lauriola8Giampietro Zanette9Stefano Tamburin10Department of Neurological and Movement Sciences, University of Verona, Piazzale Scuro 10, 37134 Verona, ItalyDepartment of Neurosciences, Sciences NPSRR, University of Padova, Via Giustiniani 5, 35128 Padova, ItalyNeurology Unit, Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello, Piazzetta Salerno 3, 90146 Palermo, ItalyDepartment of Neurosciences, Sciences NPSRR, University of Padova, Via Giustiniani 5, 35128 Padova, ItalyDepartment of Neurosciences, Sciences NPSRR, University of Padova, Via Giustiniani 5, 35128 Padova, ItalyInternal Medicine Unit, Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello, Piazzetta Salerno 3, 90146 Palermo, ItalyDiabetology Unit, Pederzoli Hospital, Via Monte Baldo 24, 37019 Peschiera del Garda, ItalyNeurology Unit, Pederzoli Hospital, Via Monte Baldo 24, 37019 Peschiera del Garda, ItalyNeurology Unit, Pederzoli Hospital, Via Monte Baldo 24, 37019 Peschiera del Garda, ItalyNeurology Unit, Pederzoli Hospital, Via Monte Baldo 24, 37019 Peschiera del Garda, ItalyDepartment of Neurological and Movement Sciences, University of Verona, Piazzale Scuro 10, 37134 Verona, ItalyDiabetic peripheral neuropathy (DPN) is a frequent complication of type 2 diabetes mellitus (DM) and may involve small and large peripheral nerve fibers. Recent evidence suggests a role of cytokines in DPN. The paper is aimed at exploring whether the serum concentration of cytokines is associated with small and large nerve fiber function and with neuropathic pain (NP). We recruited a group of 32 type 2 DM patients who underwent serum cytokines (TNF-α, IL-2, IL-4, IL-6, and IL-10) dosage as well as electrodiagnostic and quantitative sensory testing (QST) assessment to explore damage to large and small nerve fibers. Raised serum levels of IL-6 and IL-10 correlated with markers of large nerve fiber sensory and motor axonal damage. Raised IL-10 serum level was associated with signs of motor nerve demyelination. No differences were found in pain characteristics and electrodiagnostic and QST markers of small nerve fiber function in relation to cytokines serum levels. IL-6 and IL-10 serum levels were associated with large nerve fiber damage but not to small fibers function or NP. IL-6 and IL-10 cytokines might play a role in the pathogenesis of nerve fiber damage or represent a compensatory or neuroprotective mechanism.http://dx.doi.org/10.1155/2015/547834 |
| spellingShingle | Francesca Magrinelli Chiara Briani Marcello Romano Susanna Ruggero Elisabetta Toffanin Giuseppa Triolo George Chummar Peter Marialuigia Praitano Matteo Francesco Lauriola Giampietro Zanette Stefano Tamburin The Association between Serum Cytokines and Damage to Large and Small Nerve Fibers in Diabetic Peripheral Neuropathy Journal of Diabetes Research |
| title | The Association between Serum Cytokines and Damage to Large and Small Nerve Fibers in Diabetic Peripheral Neuropathy |
| title_full | The Association between Serum Cytokines and Damage to Large and Small Nerve Fibers in Diabetic Peripheral Neuropathy |
| title_fullStr | The Association between Serum Cytokines and Damage to Large and Small Nerve Fibers in Diabetic Peripheral Neuropathy |
| title_full_unstemmed | The Association between Serum Cytokines and Damage to Large and Small Nerve Fibers in Diabetic Peripheral Neuropathy |
| title_short | The Association between Serum Cytokines and Damage to Large and Small Nerve Fibers in Diabetic Peripheral Neuropathy |
| title_sort | association between serum cytokines and damage to large and small nerve fibers in diabetic peripheral neuropathy |
| url | http://dx.doi.org/10.1155/2015/547834 |
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