Toll-Like Receptors: Role in Dermatological Disease
Toll-like receptors (TLRs) are a class of conserved receptors that recognize pathogen-associated molecular patterns (PAMPs) present in microbes. In humans, at least ten TLRs have been identified, and their recognition targets range from bacterial endotoxins to lipopeptides, DNA, dsRNA, ssRNA, fungal...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/437246 |
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| _version_ | 1841524842007887872 |
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| author | Aswin Hari Tracy L. Flach Yan Shi P. Régine Mydlarski |
| author_facet | Aswin Hari Tracy L. Flach Yan Shi P. Régine Mydlarski |
| author_sort | Aswin Hari |
| collection | DOAJ |
| description | Toll-like receptors (TLRs) are a class of conserved receptors that recognize pathogen-associated molecular patterns (PAMPs) present in microbes. In humans, at least ten TLRs have been identified, and their recognition targets range from bacterial endotoxins to lipopeptides, DNA, dsRNA, ssRNA, fungal products, and several host factors. Of dermatological interest, these receptors are expressed on several skin cells including keratinocytes, melanocytes, and Langerhans cells. TLRs are essential in identifying microbial products and are known to link the innate and adaptive immune systems. Over the years, there have been significant advances in our understanding of TLRs in skin inflammation, cutaneous malignancies, and defence mechanisms. In this paper, we will describe the association between TLRs and various skin pathologies and discuss proposed TLR therapeutics. |
| format | Article |
| id | doaj-art-34149c68e017438f89e21930ecf9552f |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-34149c68e017438f89e21930ecf9552f2025-02-03T05:47:10ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/437246437246Toll-Like Receptors: Role in Dermatological DiseaseAswin Hari0Tracy L. Flach1Yan Shi2P. Régine Mydlarski3Immunology Research Group, University of Calgary, Calgary, AB, T2N 4N1, CanadaImmunology Research Group, University of Calgary, Calgary, AB, T2N 4N1, CanadaImmunology Research Group, University of Calgary, Calgary, AB, T2N 4N1, CanadaImmunology Research Group, University of Calgary, Calgary, AB, T2N 4N1, CanadaToll-like receptors (TLRs) are a class of conserved receptors that recognize pathogen-associated molecular patterns (PAMPs) present in microbes. In humans, at least ten TLRs have been identified, and their recognition targets range from bacterial endotoxins to lipopeptides, DNA, dsRNA, ssRNA, fungal products, and several host factors. Of dermatological interest, these receptors are expressed on several skin cells including keratinocytes, melanocytes, and Langerhans cells. TLRs are essential in identifying microbial products and are known to link the innate and adaptive immune systems. Over the years, there have been significant advances in our understanding of TLRs in skin inflammation, cutaneous malignancies, and defence mechanisms. In this paper, we will describe the association between TLRs and various skin pathologies and discuss proposed TLR therapeutics.http://dx.doi.org/10.1155/2010/437246 |
| spellingShingle | Aswin Hari Tracy L. Flach Yan Shi P. Régine Mydlarski Toll-Like Receptors: Role in Dermatological Disease Mediators of Inflammation |
| title | Toll-Like Receptors: Role in Dermatological Disease |
| title_full | Toll-Like Receptors: Role in Dermatological Disease |
| title_fullStr | Toll-Like Receptors: Role in Dermatological Disease |
| title_full_unstemmed | Toll-Like Receptors: Role in Dermatological Disease |
| title_short | Toll-Like Receptors: Role in Dermatological Disease |
| title_sort | toll like receptors role in dermatological disease |
| url | http://dx.doi.org/10.1155/2010/437246 |
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