Risk Factors for Sepsis Based on Sepsis-3 Criteria after Orthotopic Liver Transplantation
Sepsis is a common complication of solid organ transplant procedures and, in particular, can affect the prognosis of orthotopic liver transplantation (OLT). This retrospective study determined the pre-, peri-, and postoperative risk factors for sepsis after OLT, using as reference the 2016 Third Int...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/8703172 |
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| author | Yanling Wang Yu Gu Fei Huang Dezhao Liu Zheng Zhang Niman Zhou Jiani Liang Changyin Lu Dongdong Yuan Ziqing Hei |
| author_facet | Yanling Wang Yu Gu Fei Huang Dezhao Liu Zheng Zhang Niman Zhou Jiani Liang Changyin Lu Dongdong Yuan Ziqing Hei |
| author_sort | Yanling Wang |
| collection | DOAJ |
| description | Sepsis is a common complication of solid organ transplant procedures and, in particular, can affect the prognosis of orthotopic liver transplantation (OLT). This retrospective study determined the pre-, peri-, and postoperative risk factors for sepsis after OLT, using as reference the 2016 Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). Pre-, peri-, and postoperative clinical data of the sepsis-positive (n=85) and sepsis-negative (n=41) groups were analyzed for potential risk factors of OLT-related sepsis. The sepsis-positive patients had a significantly higher rate of dialysis (49.4%), longer time under mechanical ventilation (1.5 d), higher hospitalization costs (0.41 million RMB), and worse survival rate (68.5%), compared with the sepsis-negative patients (4.8%, 1 d, 0.30 million RMB, and 73.1%, resp.). The multivariate logistic analysis identified the following as risk factors for OLT-related sepsis: preoperative Child-Pugh grade C (OR 10.43; 95% CI 2.081–52.292; P=0.004), preoperative hypercalcemia (OR 6.372; 95% CI 1.693–23.98; P=0.006), and perioperative acidosis (OR 6.364; 95% CI 1.196–33.869; P=0.030). Patients with preoperative Child-Pugh grade C, preoperative hypercalcemia, or perioperative acidosis are at higher risk for developing sepsis after OLT. When any of these problems occur, timely sepsis management should be planned. |
| format | Article |
| id | doaj-art-3411b6b750b64ce2ae9070550a49c414 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3411b6b750b64ce2ae9070550a49c4142025-02-03T05:58:12ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/87031728703172Risk Factors for Sepsis Based on Sepsis-3 Criteria after Orthotopic Liver TransplantationYanling Wang0Yu Gu1Fei Huang2Dezhao Liu3Zheng Zhang4Niman Zhou5Jiani Liang6Changyin Lu7Dongdong Yuan8Ziqing Hei9Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou City, Guangdong Province, ChinaDepartment of Anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou City, Guangdong Province, ChinaDepartment of Anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou City, Guangdong Province, ChinaDepartment of Anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou City, Guangdong Province, ChinaDepartment of Anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou City, Guangdong Province, ChinaDepartment of Anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou City, Guangdong Province, ChinaDepartment of Anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou City, Guangdong Province, ChinaDepartment of Anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou City, Guangdong Province, ChinaDepartment of Anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou City, Guangdong Province, ChinaDepartment of Anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou City, Guangdong Province, ChinaSepsis is a common complication of solid organ transplant procedures and, in particular, can affect the prognosis of orthotopic liver transplantation (OLT). This retrospective study determined the pre-, peri-, and postoperative risk factors for sepsis after OLT, using as reference the 2016 Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). Pre-, peri-, and postoperative clinical data of the sepsis-positive (n=85) and sepsis-negative (n=41) groups were analyzed for potential risk factors of OLT-related sepsis. The sepsis-positive patients had a significantly higher rate of dialysis (49.4%), longer time under mechanical ventilation (1.5 d), higher hospitalization costs (0.41 million RMB), and worse survival rate (68.5%), compared with the sepsis-negative patients (4.8%, 1 d, 0.30 million RMB, and 73.1%, resp.). The multivariate logistic analysis identified the following as risk factors for OLT-related sepsis: preoperative Child-Pugh grade C (OR 10.43; 95% CI 2.081–52.292; P=0.004), preoperative hypercalcemia (OR 6.372; 95% CI 1.693–23.98; P=0.006), and perioperative acidosis (OR 6.364; 95% CI 1.196–33.869; P=0.030). Patients with preoperative Child-Pugh grade C, preoperative hypercalcemia, or perioperative acidosis are at higher risk for developing sepsis after OLT. When any of these problems occur, timely sepsis management should be planned.http://dx.doi.org/10.1155/2018/8703172 |
| spellingShingle | Yanling Wang Yu Gu Fei Huang Dezhao Liu Zheng Zhang Niman Zhou Jiani Liang Changyin Lu Dongdong Yuan Ziqing Hei Risk Factors for Sepsis Based on Sepsis-3 Criteria after Orthotopic Liver Transplantation Mediators of Inflammation |
| title | Risk Factors for Sepsis Based on Sepsis-3 Criteria after Orthotopic Liver Transplantation |
| title_full | Risk Factors for Sepsis Based on Sepsis-3 Criteria after Orthotopic Liver Transplantation |
| title_fullStr | Risk Factors for Sepsis Based on Sepsis-3 Criteria after Orthotopic Liver Transplantation |
| title_full_unstemmed | Risk Factors for Sepsis Based on Sepsis-3 Criteria after Orthotopic Liver Transplantation |
| title_short | Risk Factors for Sepsis Based on Sepsis-3 Criteria after Orthotopic Liver Transplantation |
| title_sort | risk factors for sepsis based on sepsis 3 criteria after orthotopic liver transplantation |
| url | http://dx.doi.org/10.1155/2018/8703172 |
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