Antibodies Against β2-Glycoprotein I Complexed With an Oxidised Lipoprotein Relate to Intima Thickening of Carotid Arteries in Primary Antiphospholipid Syndrome
To explore whether antibodies against β2-glycoprotein I (β2GPI) complexed to 7-ketocholesteryl-9-carboxynonanoate (oxLig-1) and to oxidised low-density lipoproteins (oxLDL) relate to paraoxonase activity (PONa) and/or intima media thickness (IMT) of carotid arteries in primary antiphospholipid syndr...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1080/17402520600554930 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552556455264256 |
|---|---|
| author | P. R. J. Ames J. Delgado Alves L. R. Lopez F. Gentile A. Margarita L. Pizzella J. Batuca G. Scenna V. Brancaccio E. Matsuura |
| author_facet | P. R. J. Ames J. Delgado Alves L. R. Lopez F. Gentile A. Margarita L. Pizzella J. Batuca G. Scenna V. Brancaccio E. Matsuura |
| author_sort | P. R. J. Ames |
| collection | DOAJ |
| description | To explore whether antibodies against β2-glycoprotein I (β2GPI) complexed to 7-ketocholesteryl-9-carboxynonanoate (oxLig-1) and to oxidised low-density lipoproteins (oxLDL) relate to paraoxonase activity (PONa) and/or intima media thickness (IMT) of carotid arteries in primary antiphospholipid syndrome (PAPS). As many as 29 thrombotic patients with PAPS, 10 subjects with idiopathic antiphospholipid antibodies (aPL) without thrombosis, 17 thrombotic patients with inherited thrombophilia and 23 healthy controls were investigated. The following were measured in all participants: β2GPI−oxLDL complexes, IgG anti-β2GPI−oxLig-1, IgG anti-β2GPI−oxLDL antibodies (ELISA), PONa, (para-nitrophenol method), IMT of common carotid (CC) artery, carotid bifurcation (B), internal carotid (IC) by high resolution sonography. β2GPI−oxLDL complex was highest in the control group (p < 0.01), whereas, IgG anti-β2GPI−oxLig1 and IgG anti-β2GPI−oxLDL were highest in PAPS (p < 0.0001). In healthy controls, β2GPI−oxLDL complexes positively correlated to IMT of the IC (p = 0.007) and negatively to PONa after correction for age (p < 0.03). PONa inversely correlated with age (p = 0.008). In PAPS, IgG anti-2GPI−oxLig-1 independently predicted PONa (p = 0.02) and IMT of B (p = 0.003), CC, (p = 0.03) and of IC (p = 0.04). In PAPS, PONa inversely correlated to the IMT of B, CC and IC (p = 0.01, 0.02 and 0.003, respectively). IgG anti-2GPI−oxLig-1 may be involved in PAPS related atherogenesis via decreased PON activity. |
| format | Article |
| id | doaj-art-340e9a345bff4079849977d91b37d387 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-340e9a345bff4079849977d91b37d3872025-02-03T05:58:19ZengWileyClinical and Developmental Immunology1740-25221740-25302006-01-011311910.1080/17402520600554930Antibodies Against β2-Glycoprotein I Complexed With an Oxidised Lipoprotein Relate to Intima Thickening of Carotid Arteries in Primary Antiphospholipid SyndromeP. R. J. Ames0J. Delgado Alves1L. R. Lopez2F. Gentile3A. Margarita4L. Pizzella5J. Batuca6G. Scenna7V. Brancaccio8E. Matsuura9Academic Department of Rheumatology, Leeds General Infirmary, Leeds, UKDepartment of Pharmacology, Faculty of Medical Sciences, New University of Lisbon, Lisbon, PortugalCorgenix, Inc., Westminster, Colorado, USADepartment of Health Sciences (SpeS), Molise University, Campobasso, ItalyAngiology and Coagulation Units Cardarelli Hospital, Naples, ItalyDepartment of Animal, Agricultural & Environmental Sciences (SAVA), Molise University, Campobasso, ItalyDepartment of Pharmacology, Faculty of Medical Sciences, New University of Lisbon, Lisbon, PortugalAngiology and Coagulation Units Cardarelli Hospital, Naples, ItalyAngiology and Coagulation Units Cardarelli Hospital, Naples, ItalyDepartment of Cell Chemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, JapanTo explore whether antibodies against β2-glycoprotein I (β2GPI) complexed to 7-ketocholesteryl-9-carboxynonanoate (oxLig-1) and to oxidised low-density lipoproteins (oxLDL) relate to paraoxonase activity (PONa) and/or intima media thickness (IMT) of carotid arteries in primary antiphospholipid syndrome (PAPS). As many as 29 thrombotic patients with PAPS, 10 subjects with idiopathic antiphospholipid antibodies (aPL) without thrombosis, 17 thrombotic patients with inherited thrombophilia and 23 healthy controls were investigated. The following were measured in all participants: β2GPI−oxLDL complexes, IgG anti-β2GPI−oxLig-1, IgG anti-β2GPI−oxLDL antibodies (ELISA), PONa, (para-nitrophenol method), IMT of common carotid (CC) artery, carotid bifurcation (B), internal carotid (IC) by high resolution sonography. β2GPI−oxLDL complex was highest in the control group (p < 0.01), whereas, IgG anti-β2GPI−oxLig1 and IgG anti-β2GPI−oxLDL were highest in PAPS (p < 0.0001). In healthy controls, β2GPI−oxLDL complexes positively correlated to IMT of the IC (p = 0.007) and negatively to PONa after correction for age (p < 0.03). PONa inversely correlated with age (p = 0.008). In PAPS, IgG anti-2GPI−oxLig-1 independently predicted PONa (p = 0.02) and IMT of B (p = 0.003), CC, (p = 0.03) and of IC (p = 0.04). In PAPS, PONa inversely correlated to the IMT of B, CC and IC (p = 0.01, 0.02 and 0.003, respectively). IgG anti-2GPI−oxLig-1 may be involved in PAPS related atherogenesis via decreased PON activity.http://dx.doi.org/10.1080/17402520600554930 |
| spellingShingle | P. R. J. Ames J. Delgado Alves L. R. Lopez F. Gentile A. Margarita L. Pizzella J. Batuca G. Scenna V. Brancaccio E. Matsuura Antibodies Against β2-Glycoprotein I Complexed With an Oxidised Lipoprotein Relate to Intima Thickening of Carotid Arteries in Primary Antiphospholipid Syndrome Clinical and Developmental Immunology |
| title | Antibodies Against β2-Glycoprotein I Complexed With an Oxidised Lipoprotein Relate to Intima Thickening of Carotid Arteries in Primary Antiphospholipid Syndrome |
| title_full | Antibodies Against β2-Glycoprotein I Complexed With an Oxidised Lipoprotein Relate to Intima Thickening of Carotid Arteries in Primary Antiphospholipid Syndrome |
| title_fullStr | Antibodies Against β2-Glycoprotein I Complexed With an Oxidised Lipoprotein Relate to Intima Thickening of Carotid Arteries in Primary Antiphospholipid Syndrome |
| title_full_unstemmed | Antibodies Against β2-Glycoprotein I Complexed With an Oxidised Lipoprotein Relate to Intima Thickening of Carotid Arteries in Primary Antiphospholipid Syndrome |
| title_short | Antibodies Against β2-Glycoprotein I Complexed With an Oxidised Lipoprotein Relate to Intima Thickening of Carotid Arteries in Primary Antiphospholipid Syndrome |
| title_sort | antibodies against β2 glycoprotein i complexed with an oxidised lipoprotein relate to intima thickening of carotid arteries in primary antiphospholipid syndrome |
| url | http://dx.doi.org/10.1080/17402520600554930 |
| work_keys_str_mv | AT prjames antibodiesagainstb2glycoproteinicomplexedwithanoxidisedlipoproteinrelatetointimathickeningofcarotidarteriesinprimaryantiphospholipidsyndrome AT jdelgadoalves antibodiesagainstb2glycoproteinicomplexedwithanoxidisedlipoproteinrelatetointimathickeningofcarotidarteriesinprimaryantiphospholipidsyndrome AT lrlopez antibodiesagainstb2glycoproteinicomplexedwithanoxidisedlipoproteinrelatetointimathickeningofcarotidarteriesinprimaryantiphospholipidsyndrome AT fgentile antibodiesagainstb2glycoproteinicomplexedwithanoxidisedlipoproteinrelatetointimathickeningofcarotidarteriesinprimaryantiphospholipidsyndrome AT amargarita antibodiesagainstb2glycoproteinicomplexedwithanoxidisedlipoproteinrelatetointimathickeningofcarotidarteriesinprimaryantiphospholipidsyndrome AT lpizzella antibodiesagainstb2glycoproteinicomplexedwithanoxidisedlipoproteinrelatetointimathickeningofcarotidarteriesinprimaryantiphospholipidsyndrome AT jbatuca antibodiesagainstb2glycoproteinicomplexedwithanoxidisedlipoproteinrelatetointimathickeningofcarotidarteriesinprimaryantiphospholipidsyndrome AT gscenna antibodiesagainstb2glycoproteinicomplexedwithanoxidisedlipoproteinrelatetointimathickeningofcarotidarteriesinprimaryantiphospholipidsyndrome AT vbrancaccio antibodiesagainstb2glycoproteinicomplexedwithanoxidisedlipoproteinrelatetointimathickeningofcarotidarteriesinprimaryantiphospholipidsyndrome AT ematsuura antibodiesagainstb2glycoproteinicomplexedwithanoxidisedlipoproteinrelatetointimathickeningofcarotidarteriesinprimaryantiphospholipidsyndrome |