Post-translational modifications of collagen and its related diseases in metabolic pathways
As the most abundant and essential structural protein in the human body, collagen is ubiquitously present in the interstitium of nearly all solid organs, playing a crucial role in maintaining the structural integrity and functional stability of human tissues and organs. Disorders associated with col...
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| Language: | English |
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Elsevier
2025-04-01
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| Series: | Acta Pharmaceutica Sinica B |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383525000504 |
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| author | Linghong Guo Weiyi Xiang Zhaoping Pan He Gu Xian Jiang |
| author_facet | Linghong Guo Weiyi Xiang Zhaoping Pan He Gu Xian Jiang |
| author_sort | Linghong Guo |
| collection | DOAJ |
| description | As the most abundant and essential structural protein in the human body, collagen is ubiquitously present in the interstitium of nearly all solid organs, playing a crucial role in maintaining the structural integrity and functional stability of human tissues and organs. Disorders associated with collagen structure and metabolisms impose a significant burden on society and healthcare systems. Post-translational modifications (PTMs) are essential steps in collagen metabolism, and recent studies have indicated that aberrant regulation of PTMs plays a pivotal role in the pathogenesis and progress of collagen-related disorders, including liver, kidney, heart, lung, and skin fibrosis, as well as keloid. This review provides a comprehensive summary of the regulatory mechanisms of both traditional and novel PTMs in collagen metabolism and collagen-related diseases. Furthermore, we summarize the drugs that modulate PTMs and their effects, with the aim of elucidating the pathophysiology of collagen-related diseases and provide new insights for their diagnosis, prevention, and treatment. |
| format | Article |
| id | doaj-art-340e6732e3fb4dceaa20cf29aac404db |
| institution | OA Journals |
| issn | 2211-3835 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj-art-340e6732e3fb4dceaa20cf29aac404db2025-08-20T01:49:05ZengElsevierActa Pharmaceutica Sinica B2211-38352025-04-011541773179510.1016/j.apsb.2025.02.007Post-translational modifications of collagen and its related diseases in metabolic pathwaysLinghong Guo0Weiyi Xiang1Zhaoping Pan2He Gu3Xian Jiang4Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology (CIII), Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China; Corresponding authors.Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology (CIII), Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology (CIII), Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology (CIII), Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China; Corresponding authors.Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology (CIII), Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China; Corresponding authors.As the most abundant and essential structural protein in the human body, collagen is ubiquitously present in the interstitium of nearly all solid organs, playing a crucial role in maintaining the structural integrity and functional stability of human tissues and organs. Disorders associated with collagen structure and metabolisms impose a significant burden on society and healthcare systems. Post-translational modifications (PTMs) are essential steps in collagen metabolism, and recent studies have indicated that aberrant regulation of PTMs plays a pivotal role in the pathogenesis and progress of collagen-related disorders, including liver, kidney, heart, lung, and skin fibrosis, as well as keloid. This review provides a comprehensive summary of the regulatory mechanisms of both traditional and novel PTMs in collagen metabolism and collagen-related diseases. Furthermore, we summarize the drugs that modulate PTMs and their effects, with the aim of elucidating the pathophysiology of collagen-related diseases and provide new insights for their diagnosis, prevention, and treatment.http://www.sciencedirect.com/science/article/pii/S2211383525000504CollagenCollagen metabolismFibrosisPost-translational modificationsEpigenetic modificationEpigenetics |
| spellingShingle | Linghong Guo Weiyi Xiang Zhaoping Pan He Gu Xian Jiang Post-translational modifications of collagen and its related diseases in metabolic pathways Acta Pharmaceutica Sinica B Collagen Collagen metabolism Fibrosis Post-translational modifications Epigenetic modification Epigenetics |
| title | Post-translational modifications of collagen and its related diseases in metabolic pathways |
| title_full | Post-translational modifications of collagen and its related diseases in metabolic pathways |
| title_fullStr | Post-translational modifications of collagen and its related diseases in metabolic pathways |
| title_full_unstemmed | Post-translational modifications of collagen and its related diseases in metabolic pathways |
| title_short | Post-translational modifications of collagen and its related diseases in metabolic pathways |
| title_sort | post translational modifications of collagen and its related diseases in metabolic pathways |
| topic | Collagen Collagen metabolism Fibrosis Post-translational modifications Epigenetic modification Epigenetics |
| url | http://www.sciencedirect.com/science/article/pii/S2211383525000504 |
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