Hypomagnesemia, insulin secretion and action in patients without diabetes, 1 year after kidney transplantation
IntroductionHypomagnesemia after kidney transplantation has been reported as a potential risk factor for development of post-transplant diabetes mellitus.MethodsIn kidney transplant recipients undergoing an oral glucose tolerance test during one-year surveillance follow-up we estimated insulin sensi...
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Frontiers Media S.A.
2025-01-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1492871/full |
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| author | Rasmus K. Carlsen Anders Åsberg Anders Åsberg My Svensson My Svensson Kåre I. Birkeland Kåre I. Birkeland Hanne S. Jørgensen Hanne S. Jørgensen Iain Bressendorff Hanne L. Gulseth Hanne L. Gulseth Karsten Midtvedt Espen Nordheim Espen Nordheim Trond G. Jenssen |
| author_facet | Rasmus K. Carlsen Anders Åsberg Anders Åsberg My Svensson My Svensson Kåre I. Birkeland Kåre I. Birkeland Hanne S. Jørgensen Hanne S. Jørgensen Iain Bressendorff Hanne L. Gulseth Hanne L. Gulseth Karsten Midtvedt Espen Nordheim Espen Nordheim Trond G. Jenssen |
| author_sort | Rasmus K. Carlsen |
| collection | DOAJ |
| description | IntroductionHypomagnesemia after kidney transplantation has been reported as a potential risk factor for development of post-transplant diabetes mellitus.MethodsIn kidney transplant recipients undergoing an oral glucose tolerance test during one-year surveillance follow-up we estimated insulin sensitivity with the Matsuda index, a modified Stumvoll index, and HOMA-2IR. First and second phase insulin secretion was assessed using the Stumvoll equation. Participants were categorized into tertiles by plasma magnesium levels, (<0.7, 07–0.78,>0.78 mmol/L).ResultsWe included 208 patients (62% men, median age 51 years). Patients in the lowest compared to the highest magnesium tertile had higher measured GFR (mean 59 vs. 49 mL/min, p = 0.002), tacrolimus trough concentration (mean 6.7 vs. 5.5 μg/L, p < 0.001), and fasting plasma glucose (mean 5.5 vs. 5.3 mmol/L, p = 0.03). There was no significant difference in the Matsuda index between magnesium tertiles, nor in insulin sensitivity assessed by modified Stumvoll index, HOMA-2IR, first or second phase insulin. Results indicate a non-significant trend toward lower disposition index in the lowest vs. highest tertile (p = 0.052).ConclusionIn kidney transplant recipients with lower compared to normal plasma magnesium levels we found a higher fasting plasma glucose but no differences in insulin sensitivity indexes nor dynamic insulin measurements. |
| format | Article |
| id | doaj-art-34091adc3f004d2581dedcc6e2d71848 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-34091adc3f004d2581dedcc6e2d718482025-01-22T18:39:11ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011210.3389/fmed.2025.14928711492871Hypomagnesemia, insulin secretion and action in patients without diabetes, 1 year after kidney transplantationRasmus K. Carlsen0Anders Åsberg1Anders Åsberg2My Svensson3My Svensson4Kåre I. Birkeland5Kåre I. Birkeland6Hanne S. Jørgensen7Hanne S. Jørgensen8Iain Bressendorff9Hanne L. Gulseth10Hanne L. Gulseth11Karsten Midtvedt12Espen Nordheim13Espen Nordheim14Trond G. Jenssen15Department of Transplantation Medicine, Oslo University Hospital and University of Oslo, Oslo, NorwayDepartment of Transplantation Medicine, Oslo University Hospital and University of Oslo, Oslo, NorwayDepartment of Pharmacy, University of Oslo, Oslo, NorwayDepartment of Nephrology, Akershus University Hospital, Lørenskog, NorwayDepartment of Nephrology, Aalborg University Hospital, Aalborg, DenmarkDepartment of Transplantation Medicine, Oslo University Hospital and University of Oslo, Oslo, NorwayInstitute of Clinical Medicine, University of Oslo, Oslo, NorwayDepartment of Kidney Disease, Aarhus University Hospital, Aarhus, DenmarkInstitute of Clinical Medicine, Aarhus University, Aarhus, DenmarkDepartment of Nephrology, Herlev and Gentofte Hospital, Herlev, DenmarkInstitute of Clinical Medicine, University of Oslo, Oslo, NorwayDivision of Mental and Physical Health, Norwegian Institute of Public Health, Oslo, NorwayDepartment of Transplantation Medicine, Oslo University Hospital and University of Oslo, Oslo, NorwayDepartment of Transplantation Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway0Department of Nephrology, Ullevål Hospital, Oslo University Hospital, Oslo, NorwayDepartment of Transplantation Medicine, Oslo University Hospital and University of Oslo, Oslo, NorwayIntroductionHypomagnesemia after kidney transplantation has been reported as a potential risk factor for development of post-transplant diabetes mellitus.MethodsIn kidney transplant recipients undergoing an oral glucose tolerance test during one-year surveillance follow-up we estimated insulin sensitivity with the Matsuda index, a modified Stumvoll index, and HOMA-2IR. First and second phase insulin secretion was assessed using the Stumvoll equation. Participants were categorized into tertiles by plasma magnesium levels, (<0.7, 07–0.78,>0.78 mmol/L).ResultsWe included 208 patients (62% men, median age 51 years). Patients in the lowest compared to the highest magnesium tertile had higher measured GFR (mean 59 vs. 49 mL/min, p = 0.002), tacrolimus trough concentration (mean 6.7 vs. 5.5 μg/L, p < 0.001), and fasting plasma glucose (mean 5.5 vs. 5.3 mmol/L, p = 0.03). There was no significant difference in the Matsuda index between magnesium tertiles, nor in insulin sensitivity assessed by modified Stumvoll index, HOMA-2IR, first or second phase insulin. Results indicate a non-significant trend toward lower disposition index in the lowest vs. highest tertile (p = 0.052).ConclusionIn kidney transplant recipients with lower compared to normal plasma magnesium levels we found a higher fasting plasma glucose but no differences in insulin sensitivity indexes nor dynamic insulin measurements.https://www.frontiersin.org/articles/10.3389/fmed.2025.1492871/fullhypomagnesemiakidney transplantationpost-transplant diabetes mellitusinsulin secretioninsulin actionoral glucose tolerance test |
| spellingShingle | Rasmus K. Carlsen Anders Åsberg Anders Åsberg My Svensson My Svensson Kåre I. Birkeland Kåre I. Birkeland Hanne S. Jørgensen Hanne S. Jørgensen Iain Bressendorff Hanne L. Gulseth Hanne L. Gulseth Karsten Midtvedt Espen Nordheim Espen Nordheim Trond G. Jenssen Hypomagnesemia, insulin secretion and action in patients without diabetes, 1 year after kidney transplantation Frontiers in Medicine hypomagnesemia kidney transplantation post-transplant diabetes mellitus insulin secretion insulin action oral glucose tolerance test |
| title | Hypomagnesemia, insulin secretion and action in patients without diabetes, 1 year after kidney transplantation |
| title_full | Hypomagnesemia, insulin secretion and action in patients without diabetes, 1 year after kidney transplantation |
| title_fullStr | Hypomagnesemia, insulin secretion and action in patients without diabetes, 1 year after kidney transplantation |
| title_full_unstemmed | Hypomagnesemia, insulin secretion and action in patients without diabetes, 1 year after kidney transplantation |
| title_short | Hypomagnesemia, insulin secretion and action in patients without diabetes, 1 year after kidney transplantation |
| title_sort | hypomagnesemia insulin secretion and action in patients without diabetes 1 year after kidney transplantation |
| topic | hypomagnesemia kidney transplantation post-transplant diabetes mellitus insulin secretion insulin action oral glucose tolerance test |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1492871/full |
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