Animal-sourced model of human norovirus infection predicted using environmental DNA metabarcoding analysis
Human noroviruses (HNVs) are one of the major causes of food poisoning and severe gastroenteritis. However, prevention and medical treatment of HNV disease is underdeveloped due to the lack of ecological understanding of the HNVs including their host organisms. We address the potential source animal...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-04-01
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| Series: | Journal of Freshwater Ecology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02705060.2023.2293171 |
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| author | Yukuto Sato Jun Yasuda Masahiro Sakurai |
| author_facet | Yukuto Sato Jun Yasuda Masahiro Sakurai |
| author_sort | Yukuto Sato |
| collection | DOAJ |
| description | Human noroviruses (HNVs) are one of the major causes of food poisoning and severe gastroenteritis. However, prevention and medical treatment of HNV disease is underdeveloped due to the lack of ecological understanding of the HNVs including their host organisms. We address the potential source animals of HNVs based on the environmental DNA metabarcoding analysis. By focusing on the HNV-epidemic area in Japan, we found several bird species of ducks, pochards, carrion crow, and swan showing significant cross-correlation with the HNV detection from cultured oysters. Humans and livestock mammals do not exhibit correlation with HNVs. These results suggest an avian-sourced, non-human- or sewage-mediated model of HNV infection. Unraveling the unknown host animals of pathogens like HNV facilitates artificial propagation of the pathogen, leading to vaccine and small molecule drug development. |
| format | Article |
| id | doaj-art-340622f2c0d2434384ad60c898b4bf71 |
| institution | OA Journals |
| issn | 0270-5060 2156-6941 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Freshwater Ecology |
| spelling | doaj-art-340622f2c0d2434384ad60c898b4bf712025-08-20T02:36:19ZengTaylor & Francis GroupJournal of Freshwater Ecology0270-50602156-69412024-04-0139110.1080/02705060.2023.2293171Animal-sourced model of human norovirus infection predicted using environmental DNA metabarcoding analysisYukuto Sato0Jun Yasuda1Masahiro Sakurai2Faculty of Medicine, Research Laboratory Center, University of the Ryukyus, Nishihara, Okinawa, JapanDivision of Molecular and Cellular Oncology, Miyagi Cancer Center Research Institute, Natori, Miyagi, JapanHealth Care Center, Sendai University, Shibata, Miyagi, JapanHuman noroviruses (HNVs) are one of the major causes of food poisoning and severe gastroenteritis. However, prevention and medical treatment of HNV disease is underdeveloped due to the lack of ecological understanding of the HNVs including their host organisms. We address the potential source animals of HNVs based on the environmental DNA metabarcoding analysis. By focusing on the HNV-epidemic area in Japan, we found several bird species of ducks, pochards, carrion crow, and swan showing significant cross-correlation with the HNV detection from cultured oysters. Humans and livestock mammals do not exhibit correlation with HNVs. These results suggest an avian-sourced, non-human- or sewage-mediated model of HNV infection. Unraveling the unknown host animals of pathogens like HNV facilitates artificial propagation of the pathogen, leading to vaccine and small molecule drug development.https://www.tandfonline.com/doi/10.1080/02705060.2023.2293171NVhost animaleco-epidemiology |
| spellingShingle | Yukuto Sato Jun Yasuda Masahiro Sakurai Animal-sourced model of human norovirus infection predicted using environmental DNA metabarcoding analysis Journal of Freshwater Ecology NV host animal eco-epidemiology |
| title | Animal-sourced model of human norovirus infection predicted using environmental DNA metabarcoding analysis |
| title_full | Animal-sourced model of human norovirus infection predicted using environmental DNA metabarcoding analysis |
| title_fullStr | Animal-sourced model of human norovirus infection predicted using environmental DNA metabarcoding analysis |
| title_full_unstemmed | Animal-sourced model of human norovirus infection predicted using environmental DNA metabarcoding analysis |
| title_short | Animal-sourced model of human norovirus infection predicted using environmental DNA metabarcoding analysis |
| title_sort | animal sourced model of human norovirus infection predicted using environmental dna metabarcoding analysis |
| topic | NV host animal eco-epidemiology |
| url | https://www.tandfonline.com/doi/10.1080/02705060.2023.2293171 |
| work_keys_str_mv | AT yukutosato animalsourcedmodelofhumannorovirusinfectionpredictedusingenvironmentaldnametabarcodinganalysis AT junyasuda animalsourcedmodelofhumannorovirusinfectionpredictedusingenvironmentaldnametabarcodinganalysis AT masahirosakurai animalsourcedmodelofhumannorovirusinfectionpredictedusingenvironmentaldnametabarcodinganalysis |