Association between acid-suppressive drugs and risk of psoriasis: retrospective study using Korean National Health Insurance Service-National Sample Cohort
Background/Aims Psoriasis is a common inflammatory skin disorder following non-specific triggers. Involvement of immune system is widely accepted for pathogenesis studies have demonstrated importance of gut microbiota in pathogenesis of inflammatory skin diseases. Proton pump inhibitor (PPI) and his...
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The Korean Association of Internal Medicine
2025-01-01
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| Series: | The Korean Journal of Internal Medicine |
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| Online Access: | http://kjim.org/upload/kjim-2024-096.pdf |
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| author | Ji Hyun Kim Joon-hong Min Young Woo Jo Jae Woo Kwon Young Her |
| author_facet | Ji Hyun Kim Joon-hong Min Young Woo Jo Jae Woo Kwon Young Her |
| author_sort | Ji Hyun Kim |
| collection | DOAJ |
| description | Background/Aims Psoriasis is a common inflammatory skin disorder following non-specific triggers. Involvement of immune system is widely accepted for pathogenesis studies have demonstrated importance of gut microbiota in pathogenesis of inflammatory skin diseases. Proton pump inhibitor (PPI) and histamine-2 receptor antagonist (H2RA) are acid-suppressive drugs widely used for acid related gastrointestinal diseases, and prolonged use has been associated with altered gut microbiota. This study aimed to investigate association between psoriasis and acid suppressing drugs in Korean population. Methods This study was conducted with 3,662 patients diagnosed with psoriasis between 2002 and 2013 in NHIS-NSC. A total of 14,648 controls were matched at 1:4 based on sex, age, and gastrointestinal disease. ORs were estimated to determine the association between acid suppressing drug use and psoriasis. Results Our study found a statistically significant association between the prolonged use of acid-suppressive drugs and the development of psoriasis in the Korean population. Specifically, patients with gastrointestinal diseases who used histamine-2 receptor antagonists (H2RA) or proton pump inhibitors (PPI) for extended periods exhibited a higher risk of developing psoriasis. The adjusted odds ratio for psoriasis was 1.89 (95% CI, 1.66–2.17) with long-term use, indicating a clear dose-response relationship. Conclusions Results from our study indicate that prolonged use of H2RA or PPI is associated with the risk of psoriasis among patients with gastrointestinal diseases in Korean population. The risk was increased in dose-response trend after adjusting for confounding variables. Clinicians should be aware of risks associated with prolonged use of acid suppressing drugs. |
| format | Article |
| id | doaj-art-340417a1624a4e33933cf7793e490908 |
| institution | DOAJ |
| issn | 1226-3303 2005-6648 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj-art-340417a1624a4e33933cf7793e4909082025-08-20T03:04:26ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482025-01-01401576410.3904/kjim.2024.096170983Association between acid-suppressive drugs and risk of psoriasis: retrospective study using Korean National Health Insurance Service-National Sample CohortJi Hyun Kim0Joon-hong Min1Young Woo Jo2Jae Woo Kwon3Young Her4 Department of Gastroenterology and Hepatology, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Korea Department of Dermatology, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Korea Department of Dermatology, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Korea Department of Allergy and Clinical Immunology, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Korea Department of Dermatology, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, KoreaBackground/Aims Psoriasis is a common inflammatory skin disorder following non-specific triggers. Involvement of immune system is widely accepted for pathogenesis studies have demonstrated importance of gut microbiota in pathogenesis of inflammatory skin diseases. Proton pump inhibitor (PPI) and histamine-2 receptor antagonist (H2RA) are acid-suppressive drugs widely used for acid related gastrointestinal diseases, and prolonged use has been associated with altered gut microbiota. This study aimed to investigate association between psoriasis and acid suppressing drugs in Korean population. Methods This study was conducted with 3,662 patients diagnosed with psoriasis between 2002 and 2013 in NHIS-NSC. A total of 14,648 controls were matched at 1:4 based on sex, age, and gastrointestinal disease. ORs were estimated to determine the association between acid suppressing drug use and psoriasis. Results Our study found a statistically significant association between the prolonged use of acid-suppressive drugs and the development of psoriasis in the Korean population. Specifically, patients with gastrointestinal diseases who used histamine-2 receptor antagonists (H2RA) or proton pump inhibitors (PPI) for extended periods exhibited a higher risk of developing psoriasis. The adjusted odds ratio for psoriasis was 1.89 (95% CI, 1.66–2.17) with long-term use, indicating a clear dose-response relationship. Conclusions Results from our study indicate that prolonged use of H2RA or PPI is associated with the risk of psoriasis among patients with gastrointestinal diseases in Korean population. The risk was increased in dose-response trend after adjusting for confounding variables. Clinicians should be aware of risks associated with prolonged use of acid suppressing drugs.http://kjim.org/upload/kjim-2024-096.pdfpsoriasisanti-ulcer agentsgastrointestinal microbiomeproton pump inhibitorhistamine h2 antagonists |
| spellingShingle | Ji Hyun Kim Joon-hong Min Young Woo Jo Jae Woo Kwon Young Her Association between acid-suppressive drugs and risk of psoriasis: retrospective study using Korean National Health Insurance Service-National Sample Cohort The Korean Journal of Internal Medicine psoriasis anti-ulcer agents gastrointestinal microbiome proton pump inhibitor histamine h2 antagonists |
| title | Association between acid-suppressive drugs and risk of psoriasis: retrospective study using Korean National Health Insurance Service-National Sample Cohort |
| title_full | Association between acid-suppressive drugs and risk of psoriasis: retrospective study using Korean National Health Insurance Service-National Sample Cohort |
| title_fullStr | Association between acid-suppressive drugs and risk of psoriasis: retrospective study using Korean National Health Insurance Service-National Sample Cohort |
| title_full_unstemmed | Association between acid-suppressive drugs and risk of psoriasis: retrospective study using Korean National Health Insurance Service-National Sample Cohort |
| title_short | Association between acid-suppressive drugs and risk of psoriasis: retrospective study using Korean National Health Insurance Service-National Sample Cohort |
| title_sort | association between acid suppressive drugs and risk of psoriasis retrospective study using korean national health insurance service national sample cohort |
| topic | psoriasis anti-ulcer agents gastrointestinal microbiome proton pump inhibitor histamine h2 antagonists |
| url | http://kjim.org/upload/kjim-2024-096.pdf |
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