A decision-space model explains context-specific decision-making
Abstract Optimal decision-making requires consideration of internal and external contexts. Biased decision-making is a transdiagnostic symptom of neuropsychiatric disorders. We created a computational model demonstrating how the striosome compartment of the striatum constructs a context-dependent ma...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-61466-x |
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| author | Dirk W. Beck Cory N. Heaton Luis D. Davila Lara I. Rakocevic Sabrina M. Drammis Danil Tyulmankov Atanu Giri Shreeya Umashankar Beck Qingyang Zhang Michael Pokojovy Kenichiro Negishi Alexis A. Salcido Neftali F. Reyes Andrea Y. Macias Serina A. Batson Paulina Vara Raquel J. Ibáñez Alcalá Safa B. Hossain Graham L. Waller Laura E. O’Dell Travis M. Moschak Ki A. Goosens Alexander Friedman |
| author_facet | Dirk W. Beck Cory N. Heaton Luis D. Davila Lara I. Rakocevic Sabrina M. Drammis Danil Tyulmankov Atanu Giri Shreeya Umashankar Beck Qingyang Zhang Michael Pokojovy Kenichiro Negishi Alexis A. Salcido Neftali F. Reyes Andrea Y. Macias Serina A. Batson Paulina Vara Raquel J. Ibáñez Alcalá Safa B. Hossain Graham L. Waller Laura E. O’Dell Travis M. Moschak Ki A. Goosens Alexander Friedman |
| author_sort | Dirk W. Beck |
| collection | DOAJ |
| description | Abstract Optimal decision-making requires consideration of internal and external contexts. Biased decision-making is a transdiagnostic symptom of neuropsychiatric disorders. We created a computational model demonstrating how the striosome compartment of the striatum constructs a context-dependent mathematical space for decision-making computations, and how the matrix compartment uses this space to define action value. The model explains multiple experimental results and unifies other theories like reward prediction error, roles of the direct versus indirect pathways, and roles of the striosome versus matrix, under one framework. We also found, through new analyses, that striosome and matrix neurons increase their synchrony during difficult tasks, caused by a necessary increase in dimensionality of the space. The model makes testable predictions about individual differences in disorder susceptibility, decision-making symptoms shared among neuropsychiatric disorders, and differences in neuropsychiatric disorder symptom presentation. The model provides evidence for the central role that striosomes play in neuroeconomic and disorder-affected decision-making. |
| format | Article |
| id | doaj-art-33fbf2b28c3743b9bf12865d24eeefae |
| institution | DOAJ |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-33fbf2b28c3743b9bf12865d24eeefae2025-08-20T03:05:05ZengNature PortfolioNature Communications2041-17232025-08-0116113010.1038/s41467-025-61466-xA decision-space model explains context-specific decision-makingDirk W. Beck0Cory N. Heaton1Luis D. Davila2Lara I. Rakocevic3Sabrina M. Drammis4Danil Tyulmankov5Atanu Giri6Shreeya Umashankar Beck7Qingyang Zhang8Michael Pokojovy9Kenichiro Negishi10Alexis A. Salcido11Neftali F. Reyes12Andrea Y. Macias13Serina A. Batson14Paulina Vara15Raquel J. Ibáñez Alcalá16Safa B. Hossain17Graham L. Waller18Laura E. O’Dell19Travis M. Moschak20Ki A. Goosens21Alexander Friedman22Computational Science Program, University of Texas at El PasoDepartment of Biological Sciences, University of Texas at El PasoComputational Science Program, University of Texas at El PasoComputational Science Program, University of Texas at El PasoArtificial Intelligence Laboratory, Department of Computer Science, Massachusetts Institute of TechnologyMing Hsieh Department of Electrical and Computer Engineering, Viterbi School of Engineering, University of Southern CaliforniaComputational Science Program, University of Texas at El PasoDepartment of Biological Sciences, University of Texas at El PasoDepartment of Biomedical Informatics, Harvard Medical SchoolDepartment of Mathematics and Statistics, Old Dominion UniversityNational Institute on Drug AbuseDepartment of Biological Sciences, University of Texas at El PasoDepartment of Biological Sciences, University of Texas at El PasoDepartment of Biological Sciences, University of Texas at El PasoDepartment of Biological Sciences, University of Texas at El PasoDepartment of Biological Sciences, University of Texas at El PasoDepartment of Biological Sciences, University of Texas at El PasoDepartment of Biological Sciences, University of Texas at El PasoDepartment of Biological Sciences, University of Texas at El PasoDepartment of Psychology, University of Texas at El PasoDepartment of Biological Sciences, University of Texas at El PasoDepartment of Psychiatry, Department of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiComputational Science Program, University of Texas at El PasoAbstract Optimal decision-making requires consideration of internal and external contexts. Biased decision-making is a transdiagnostic symptom of neuropsychiatric disorders. We created a computational model demonstrating how the striosome compartment of the striatum constructs a context-dependent mathematical space for decision-making computations, and how the matrix compartment uses this space to define action value. The model explains multiple experimental results and unifies other theories like reward prediction error, roles of the direct versus indirect pathways, and roles of the striosome versus matrix, under one framework. We also found, through new analyses, that striosome and matrix neurons increase their synchrony during difficult tasks, caused by a necessary increase in dimensionality of the space. The model makes testable predictions about individual differences in disorder susceptibility, decision-making symptoms shared among neuropsychiatric disorders, and differences in neuropsychiatric disorder symptom presentation. The model provides evidence for the central role that striosomes play in neuroeconomic and disorder-affected decision-making.https://doi.org/10.1038/s41467-025-61466-x |
| spellingShingle | Dirk W. Beck Cory N. Heaton Luis D. Davila Lara I. Rakocevic Sabrina M. Drammis Danil Tyulmankov Atanu Giri Shreeya Umashankar Beck Qingyang Zhang Michael Pokojovy Kenichiro Negishi Alexis A. Salcido Neftali F. Reyes Andrea Y. Macias Serina A. Batson Paulina Vara Raquel J. Ibáñez Alcalá Safa B. Hossain Graham L. Waller Laura E. O’Dell Travis M. Moschak Ki A. Goosens Alexander Friedman A decision-space model explains context-specific decision-making Nature Communications |
| title | A decision-space model explains context-specific decision-making |
| title_full | A decision-space model explains context-specific decision-making |
| title_fullStr | A decision-space model explains context-specific decision-making |
| title_full_unstemmed | A decision-space model explains context-specific decision-making |
| title_short | A decision-space model explains context-specific decision-making |
| title_sort | decision space model explains context specific decision making |
| url | https://doi.org/10.1038/s41467-025-61466-x |
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