Clinical Characteristics of Alternaria Keratitis
Purpose. Alternaria spp. are an uncommon cause of mycotic keratitis. Previous studies on Alternaria keratitis have generally been limited to case reports. We examined the clinical characteristics of Alternaria keratitis in this study. Methods. The characteristics and outcomes of 7 patients with cult...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2014/536985 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850157174618062848 |
|---|---|
| author | Ching-Hsi Hsiao Lung-Kun Yeh Hung-Chi Chen Hsin-Chiung Lin Phil Y. F. Chen David H. K. Ma Hsin-Yuan Tan |
| author_facet | Ching-Hsi Hsiao Lung-Kun Yeh Hung-Chi Chen Hsin-Chiung Lin Phil Y. F. Chen David H. K. Ma Hsin-Yuan Tan |
| author_sort | Ching-Hsi Hsiao |
| collection | DOAJ |
| description | Purpose. Alternaria spp. are an uncommon cause of mycotic keratitis. Previous studies on Alternaria keratitis have generally been limited to case reports. We examined the clinical characteristics of Alternaria keratitis in this study. Methods. The characteristics and outcomes of 7 patients with culture-proven Alternaria keratitis treated in our hospital were compared with 25 previously reported cases. Results. The risk factors for Alternaria keratitis were trauma in 5 patients and soft contact lenses in 1 patient. Six patients with early diagnosis (<2 weeks) were cured with medical antimicrobial treatment; a patch graft was required in 1 patient with perforation. When incorporated with previous reports on Alternaria keratitis (n=32), 14 (44%) infections followed trauma, 10 (31%) were associated with preexisting corneal disease or previous ocular surgery, and 5 (16%) occurred in soft contact lens wearers. Successful medical treatment was achieved in 23 (72%) patients, including 10 out of 21 eyes (48%) treated with natamycin and/or amphotericin B. Therapeutic penetrating keratoplasty was performed in 9 (28%) cases. Conclusions. Alternaria keratitis is generally associated with specific risk factors and responds to medical treatment when early diagnosis is performed and prompt antifungal treatment is initiated. |
| format | Article |
| id | doaj-art-33f8bf2478bf4ae78c159e2bd1fbb50e |
| institution | OA Journals |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-33f8bf2478bf4ae78c159e2bd1fbb50e2025-08-20T02:24:15ZengWileyJournal of Ophthalmology2090-004X2090-00582014-01-01201410.1155/2014/536985536985Clinical Characteristics of Alternaria KeratitisChing-Hsi Hsiao0Lung-Kun Yeh1Hung-Chi Chen2Hsin-Chiung Lin3Phil Y. F. Chen4David H. K. Ma5Hsin-Yuan Tan6Department of Ophthalmology, Chang Gung Memorial Hospital, No. 5 Fu-Hsin Road, Kweishan 333, Taoyuan, TaiwanDepartment of Ophthalmology, Chang Gung Memorial Hospital, No. 5 Fu-Hsin Road, Kweishan 333, Taoyuan, TaiwanDepartment of Ophthalmology, Chang Gung Memorial Hospital, No. 5 Fu-Hsin Road, Kweishan 333, Taoyuan, TaiwanDepartment of Ophthalmology, Chang Gung Memorial Hospital, No. 5 Fu-Hsin Road, Kweishan 333, Taoyuan, TaiwanDepartment of Ophthalmology, Chang Gung Memorial Hospital, No. 5 Fu-Hsin Road, Kweishan 333, Taoyuan, TaiwanDepartment of Ophthalmology, Chang Gung Memorial Hospital, No. 5 Fu-Hsin Road, Kweishan 333, Taoyuan, TaiwanDepartment of Ophthalmology, Chang Gung Memorial Hospital, No. 5 Fu-Hsin Road, Kweishan 333, Taoyuan, TaiwanPurpose. Alternaria spp. are an uncommon cause of mycotic keratitis. Previous studies on Alternaria keratitis have generally been limited to case reports. We examined the clinical characteristics of Alternaria keratitis in this study. Methods. The characteristics and outcomes of 7 patients with culture-proven Alternaria keratitis treated in our hospital were compared with 25 previously reported cases. Results. The risk factors for Alternaria keratitis were trauma in 5 patients and soft contact lenses in 1 patient. Six patients with early diagnosis (<2 weeks) were cured with medical antimicrobial treatment; a patch graft was required in 1 patient with perforation. When incorporated with previous reports on Alternaria keratitis (n=32), 14 (44%) infections followed trauma, 10 (31%) were associated with preexisting corneal disease or previous ocular surgery, and 5 (16%) occurred in soft contact lens wearers. Successful medical treatment was achieved in 23 (72%) patients, including 10 out of 21 eyes (48%) treated with natamycin and/or amphotericin B. Therapeutic penetrating keratoplasty was performed in 9 (28%) cases. Conclusions. Alternaria keratitis is generally associated with specific risk factors and responds to medical treatment when early diagnosis is performed and prompt antifungal treatment is initiated.http://dx.doi.org/10.1155/2014/536985 |
| spellingShingle | Ching-Hsi Hsiao Lung-Kun Yeh Hung-Chi Chen Hsin-Chiung Lin Phil Y. F. Chen David H. K. Ma Hsin-Yuan Tan Clinical Characteristics of Alternaria Keratitis Journal of Ophthalmology |
| title | Clinical Characteristics of Alternaria Keratitis |
| title_full | Clinical Characteristics of Alternaria Keratitis |
| title_fullStr | Clinical Characteristics of Alternaria Keratitis |
| title_full_unstemmed | Clinical Characteristics of Alternaria Keratitis |
| title_short | Clinical Characteristics of Alternaria Keratitis |
| title_sort | clinical characteristics of alternaria keratitis |
| url | http://dx.doi.org/10.1155/2014/536985 |
| work_keys_str_mv | AT chinghsihsiao clinicalcharacteristicsofalternariakeratitis AT lungkunyeh clinicalcharacteristicsofalternariakeratitis AT hungchichen clinicalcharacteristicsofalternariakeratitis AT hsinchiunglin clinicalcharacteristicsofalternariakeratitis AT philyfchen clinicalcharacteristicsofalternariakeratitis AT davidhkma clinicalcharacteristicsofalternariakeratitis AT hsinyuantan clinicalcharacteristicsofalternariakeratitis |