CLINICAL AND ELECTROCARDIOGRAPHIC SYNDROMES ASSOCIATED WITH THE RISKOF SUDDENCARDIAC DEATH: PATHOGENESIS, CLINICAL MANIFESTATIONS, DIAGNOSTIC CRITERIA, INDICATIONS FORGENETIC RESEARCHAND TREATMENT
PURPOSE. The problem of sudden cardiac death (SCD) is the most relevant in the modern cardiology , and if organic heart diseases exist, treatment strategy and prevention of SCD is developed , this problem is not solved in the patients without organic changes. Currently, a group of diseases, clinical...
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| Format: | Article |
| Language: | Russian |
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Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department
2016-03-01
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| Series: | Неотложная медицинская помощь |
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| Online Access: | https://www.jnmp.ru/jour/article/view/150 |
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| author | V. V. Rezvan I. M. Kuzmina M. A. Vashkevich |
| author_facet | V. V. Rezvan I. M. Kuzmina M. A. Vashkevich |
| author_sort | V. V. Rezvan |
| collection | DOAJ |
| description | PURPOSE. The problem of sudden cardiac death (SCD) is the most relevant in the modern cardiology , and if organic heart diseases exist, treatment strategy and prevention of SCD is developed , this problem is not solved in the patients without organic changes. Currently, a group of diseases, clinical and electrocardiographic syndromes, has emerged, that are closely associated with the formation of fatal arrhythmias. Special hazard of the course of these pathological conditions is due to the high risk of SCD, especially in young people. These diseases are not accompanied by structural changes in the myocardium and manifest themselves mainly by electrophysiological abnormalities in cardiomyocytes. Mutations in genes encoding ion channel proteins expressed in the myocardium, and their modulators, is the basis of these diseases. This fact is accounted for the unification of these diseases in the group of «channelopathies». The article presents the current diagnostic criteria for these diseases and treatments. In 2011 Guidelines of the European Society of Cardiology for genetic research in channelopathies and cardiomyopathies that have defined the indications for genetic research in this pathology, were issued. |
| format | Article |
| id | doaj-art-33f8a0f2b3e74c29bd077492e2fe6280 |
| institution | Kabale University |
| issn | 2223-9022 2541-8017 |
| language | Russian |
| publishDate | 2016-03-01 |
| publisher | Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department |
| record_format | Article |
| series | Неотложная медицинская помощь |
| spelling | doaj-art-33f8a0f2b3e74c29bd077492e2fe62802025-08-20T03:35:06ZrusSklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare DepartmentНеотложная медицинская помощь2223-90222541-80172016-03-01033947148CLINICAL AND ELECTROCARDIOGRAPHIC SYNDROMES ASSOCIATED WITH THE RISKOF SUDDENCARDIAC DEATH: PATHOGENESIS, CLINICAL MANIFESTATIONS, DIAGNOSTIC CRITERIA, INDICATIONS FORGENETIC RESEARCHAND TREATMENTV. V. Rezvan0I. M. Kuzmina1M. A. Vashkevich2Sklifosovsky Research Institute for Emergency Medicine Health Department of Moscow, MoscowSklifosovsky Research Institute for Emergency Medicine Health Department of Moscow, MoscowSklifosovsky Research Institute for Emergency Medicine Health Department of Moscow, MoscowPURPOSE. The problem of sudden cardiac death (SCD) is the most relevant in the modern cardiology , and if organic heart diseases exist, treatment strategy and prevention of SCD is developed , this problem is not solved in the patients without organic changes. Currently, a group of diseases, clinical and electrocardiographic syndromes, has emerged, that are closely associated with the formation of fatal arrhythmias. Special hazard of the course of these pathological conditions is due to the high risk of SCD, especially in young people. These diseases are not accompanied by structural changes in the myocardium and manifest themselves mainly by electrophysiological abnormalities in cardiomyocytes. Mutations in genes encoding ion channel proteins expressed in the myocardium, and their modulators, is the basis of these diseases. This fact is accounted for the unification of these diseases in the group of «channelopathies». The article presents the current diagnostic criteria for these diseases and treatments. In 2011 Guidelines of the European Society of Cardiology for genetic research in channelopathies and cardiomyopathies that have defined the indications for genetic research in this pathology, were issued.https://www.jnmp.ru/jour/article/view/150«channelopathies»prevention of sudden cardiac deathgenetic research |
| spellingShingle | V. V. Rezvan I. M. Kuzmina M. A. Vashkevich CLINICAL AND ELECTROCARDIOGRAPHIC SYNDROMES ASSOCIATED WITH THE RISKOF SUDDENCARDIAC DEATH: PATHOGENESIS, CLINICAL MANIFESTATIONS, DIAGNOSTIC CRITERIA, INDICATIONS FORGENETIC RESEARCHAND TREATMENT Неотложная медицинская помощь «channelopathies» prevention of sudden cardiac death genetic research |
| title | CLINICAL AND ELECTROCARDIOGRAPHIC SYNDROMES ASSOCIATED WITH THE RISKOF SUDDENCARDIAC DEATH: PATHOGENESIS, CLINICAL MANIFESTATIONS, DIAGNOSTIC CRITERIA, INDICATIONS FORGENETIC RESEARCHAND TREATMENT |
| title_full | CLINICAL AND ELECTROCARDIOGRAPHIC SYNDROMES ASSOCIATED WITH THE RISKOF SUDDENCARDIAC DEATH: PATHOGENESIS, CLINICAL MANIFESTATIONS, DIAGNOSTIC CRITERIA, INDICATIONS FORGENETIC RESEARCHAND TREATMENT |
| title_fullStr | CLINICAL AND ELECTROCARDIOGRAPHIC SYNDROMES ASSOCIATED WITH THE RISKOF SUDDENCARDIAC DEATH: PATHOGENESIS, CLINICAL MANIFESTATIONS, DIAGNOSTIC CRITERIA, INDICATIONS FORGENETIC RESEARCHAND TREATMENT |
| title_full_unstemmed | CLINICAL AND ELECTROCARDIOGRAPHIC SYNDROMES ASSOCIATED WITH THE RISKOF SUDDENCARDIAC DEATH: PATHOGENESIS, CLINICAL MANIFESTATIONS, DIAGNOSTIC CRITERIA, INDICATIONS FORGENETIC RESEARCHAND TREATMENT |
| title_short | CLINICAL AND ELECTROCARDIOGRAPHIC SYNDROMES ASSOCIATED WITH THE RISKOF SUDDENCARDIAC DEATH: PATHOGENESIS, CLINICAL MANIFESTATIONS, DIAGNOSTIC CRITERIA, INDICATIONS FORGENETIC RESEARCHAND TREATMENT |
| title_sort | clinical and electrocardiographic syndromes associated with the riskof suddencardiac death pathogenesis clinical manifestations diagnostic criteria indications forgenetic researchand treatment |
| topic | «channelopathies» prevention of sudden cardiac death genetic research |
| url | https://www.jnmp.ru/jour/article/view/150 |
| work_keys_str_mv | AT vvrezvan clinicalandelectrocardiographicsyndromesassociatedwiththeriskofsuddencardiacdeathpathogenesisclinicalmanifestationsdiagnosticcriteriaindicationsforgeneticresearchandtreatment AT imkuzmina clinicalandelectrocardiographicsyndromesassociatedwiththeriskofsuddencardiacdeathpathogenesisclinicalmanifestationsdiagnosticcriteriaindicationsforgeneticresearchandtreatment AT mavashkevich clinicalandelectrocardiographicsyndromesassociatedwiththeriskofsuddencardiacdeathpathogenesisclinicalmanifestationsdiagnosticcriteriaindicationsforgeneticresearchandtreatment |