Establishment of a patient-derived 3D in vitro meningioma model in xeno-free hydrogel for clinical applications

Establishment of a patient-derived 3D in vitro meningioma model in xeno-free hydrogel for clinical applications

Abstract Background Meningiomas exhibit a complex biology that, despite notable successes in preclinical studies, contributes to the failures of pharmaceutical clinical trials. Animal models using patient tumor cells closely mimic in vivo conditions but are labor-intensive, costly, and unsuitable fo...

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Main Authors: Mikkel Schou Andersen, Aaraby Yoheswaran Nielsen, Martin Wirenfeldt, Jeanette Krogh Petersen, Morten Winkler Møller, Christopher L. Powell, Anavaleria Castro, Grayson Herrgott, Tiit Mathiesen, Charlotte Aaberg Poulsen, Birgitte Brinkmann Olsen, Henning Bünsow Boldt, Christian Bonde Pedersen, Bo Halle, Frantz Rom Poulsen
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Acta Neuropathologica Communications
Subjects:
Meningioma
3D model
Organoid
In vitro model
DNA methylation
Immunohistochemistry
Online Access:https://doi.org/10.1186/s40478-025-02008-w
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