An injectable calcium sulfate-monetite biphasic cement for the treatment of critical-sized calvarial defects
Abstract The critical bone defect is a common clinical challenge worldwide, characterized by long recovery times, a substantial risk of infection, and high disability rates. There remains a significant demand for synthetic bone-repairing materials to address this issue. In this study, porous monetit...
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| Format: | Article |
| Language: | English |
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Springer
2025-07-01
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| Series: | Journal of Materials Science: Materials in Medicine |
| Online Access: | https://doi.org/10.1007/s10856-025-06911-5 |
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| author | Jianzhong Bai Dachuan Liu Luguang Ding Guoping Liu Jiaying Li Huan Wang Li Dong Chen Cui Youzhi Hong Shuangjian He Song Chen Hongtao Zhang |
| author_facet | Jianzhong Bai Dachuan Liu Luguang Ding Guoping Liu Jiaying Li Huan Wang Li Dong Chen Cui Youzhi Hong Shuangjian He Song Chen Hongtao Zhang |
| author_sort | Jianzhong Bai |
| collection | DOAJ |
| description | Abstract The critical bone defect is a common clinical challenge worldwide, characterized by long recovery times, a substantial risk of infection, and high disability rates. There remains a significant demand for synthetic bone-repairing materials to address this issue. In this study, porous monetite was synthesized through the reaction between monocalcium phosphate monohydrate and β-tricalcium phosphate, using paraffin microspheres as pore-forming agents. An injectable biphasic cement was then developed by blending the monetite granules with hemihydrate calcium sulfate, designed for minimally invasive surgical applications. The cement demonstrated excellent biocompatibility and osteogenic properties in vitro. Furthermore, in vivo studies confirmed the cement’s superior bone repair capabilities, indicating its promising potential for the treatment of critical bone defects. Graphical Abstract A highly porous composite with gradient degradation was developed by mixing porous monetite granules and hemihydrate calcium sulfate, and the composite has the effect of promoting the formation of new bone. |
| format | Article |
| id | doaj-art-33f7e11564134f88aea06547edec85de |
| institution | Kabale University |
| issn | 1573-4838 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Materials Science: Materials in Medicine |
| spelling | doaj-art-33f7e11564134f88aea06547edec85de2025-08-20T03:42:34ZengSpringerJournal of Materials Science: Materials in Medicine1573-48382025-07-0136111110.1007/s10856-025-06911-5An injectable calcium sulfate-monetite biphasic cement for the treatment of critical-sized calvarial defectsJianzhong Bai0Dachuan Liu1Luguang Ding2Guoping Liu3Jiaying Li4Huan Wang5Li Dong6Chen Cui7Youzhi Hong8Shuangjian He9Song Chen10Hongtao Zhang11Department of Orthopedic Surgery, Medical 3D Printing Center, Orthopedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow UniversityDepartment of Orthopedic Surgery, Medical 3D Printing Center, Orthopedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow UniversityDepartment of Orthopedic Surgery, Medical 3D Printing Center, Orthopedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow UniversityDepartment of Orthopedic Surgery, Medical 3D Printing Center, Orthopedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow UniversityDepartment of Orthopedic Surgery, Medical 3D Printing Center, Orthopedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow UniversityDepartment of Orthopedic Surgery, Medical 3D Printing Center, Orthopedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow UniversityDepartment of Orthopedic Surgery, Medical 3D Printing Center, Orthopedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow UniversityDepartment of Orthopedic Surgery, Medical 3D Printing Center, Orthopedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow UniversityDepartment of Orthopedic Surgery, Medical 3D Printing Center, Orthopedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow UniversityThe Affiliated Suzhou Hospital of Nanjing University Medical SchoolDepartment of Orthopedic Surgery, Medical 3D Printing Center, Orthopedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow UniversityDepartment of Orthopedic Surgery, Medical 3D Printing Center, Orthopedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow UniversityAbstract The critical bone defect is a common clinical challenge worldwide, characterized by long recovery times, a substantial risk of infection, and high disability rates. There remains a significant demand for synthetic bone-repairing materials to address this issue. In this study, porous monetite was synthesized through the reaction between monocalcium phosphate monohydrate and β-tricalcium phosphate, using paraffin microspheres as pore-forming agents. An injectable biphasic cement was then developed by blending the monetite granules with hemihydrate calcium sulfate, designed for minimally invasive surgical applications. The cement demonstrated excellent biocompatibility and osteogenic properties in vitro. Furthermore, in vivo studies confirmed the cement’s superior bone repair capabilities, indicating its promising potential for the treatment of critical bone defects. Graphical Abstract A highly porous composite with gradient degradation was developed by mixing porous monetite granules and hemihydrate calcium sulfate, and the composite has the effect of promoting the formation of new bone.https://doi.org/10.1007/s10856-025-06911-5 |
| spellingShingle | Jianzhong Bai Dachuan Liu Luguang Ding Guoping Liu Jiaying Li Huan Wang Li Dong Chen Cui Youzhi Hong Shuangjian He Song Chen Hongtao Zhang An injectable calcium sulfate-monetite biphasic cement for the treatment of critical-sized calvarial defects Journal of Materials Science: Materials in Medicine |
| title | An injectable calcium sulfate-monetite biphasic cement for the treatment of critical-sized calvarial defects |
| title_full | An injectable calcium sulfate-monetite biphasic cement for the treatment of critical-sized calvarial defects |
| title_fullStr | An injectable calcium sulfate-monetite biphasic cement for the treatment of critical-sized calvarial defects |
| title_full_unstemmed | An injectable calcium sulfate-monetite biphasic cement for the treatment of critical-sized calvarial defects |
| title_short | An injectable calcium sulfate-monetite biphasic cement for the treatment of critical-sized calvarial defects |
| title_sort | injectable calcium sulfate monetite biphasic cement for the treatment of critical sized calvarial defects |
| url | https://doi.org/10.1007/s10856-025-06911-5 |
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