The superior colliculus directs goal-oriented forelimb movements
Summary: Skilled forelimb control is essential for daily living, yet our understanding of its neural mechanisms, although extensive, remains incomplete. Here, we present evidence that the superior colliculus (SC), a major midbrain structure, is necessary for accurate forelimb reaching in mice. We fo...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724014487 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850120193542455296 |
|---|---|
| author | Shrivas Chaterji Punarva H. Belliappa Anupama Sathyamurthy |
| author_facet | Shrivas Chaterji Punarva H. Belliappa Anupama Sathyamurthy |
| author_sort | Shrivas Chaterji |
| collection | DOAJ |
| description | Summary: Skilled forelimb control is essential for daily living, yet our understanding of its neural mechanisms, although extensive, remains incomplete. Here, we present evidence that the superior colliculus (SC), a major midbrain structure, is necessary for accurate forelimb reaching in mice. We found that neurons in the lateral SC are active during goal-directed reaching, and by employing chemogenetic and phase-specific optogenetic silencing of these neurons, we show that the SC causally facilitates reach accuracy. Anatomical studies identified the deep cerebellar nuclei and substantia nigra pars reticulata as sources of inputs to the SC, while functional studies revealed a role for nigrotectal, but not cerebellotectal, neurons in controlling reach endpoints. Silencing the nigrotectal pathway caused paw deviations opposite to those seen with SC silencing, emphasizing the coordinated role of the substantia nigra and SC in regulating optimal reaching. Together, these findings establish the SC as a crucial regulator of skilled forelimb control. |
| format | Article |
| id | doaj-art-33ef4be8be894bd88e3f79a072ead020 |
| institution | OA Journals |
| issn | 2211-1247 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-33ef4be8be894bd88e3f79a072ead0202025-08-20T02:35:25ZengElsevierCell Reports2211-12472025-01-0144111509710.1016/j.celrep.2024.115097The superior colliculus directs goal-oriented forelimb movementsShrivas Chaterji0Punarva H. Belliappa1Anupama Sathyamurthy2Centre for Neuroscience, Indian Institute of Science, Bengaluru, Karnataka 560012, IndiaCentre for Neuroscience, Indian Institute of Science, Bengaluru, Karnataka 560012, IndiaCentre for Neuroscience, Indian Institute of Science, Bengaluru, Karnataka 560012, India; Corresponding authorSummary: Skilled forelimb control is essential for daily living, yet our understanding of its neural mechanisms, although extensive, remains incomplete. Here, we present evidence that the superior colliculus (SC), a major midbrain structure, is necessary for accurate forelimb reaching in mice. We found that neurons in the lateral SC are active during goal-directed reaching, and by employing chemogenetic and phase-specific optogenetic silencing of these neurons, we show that the SC causally facilitates reach accuracy. Anatomical studies identified the deep cerebellar nuclei and substantia nigra pars reticulata as sources of inputs to the SC, while functional studies revealed a role for nigrotectal, but not cerebellotectal, neurons in controlling reach endpoints. Silencing the nigrotectal pathway caused paw deviations opposite to those seen with SC silencing, emphasizing the coordinated role of the substantia nigra and SC in regulating optimal reaching. Together, these findings establish the SC as a crucial regulator of skilled forelimb control.http://www.sciencedirect.com/science/article/pii/S2211124724014487CP: Neuroscience |
| spellingShingle | Shrivas Chaterji Punarva H. Belliappa Anupama Sathyamurthy The superior colliculus directs goal-oriented forelimb movements Cell Reports CP: Neuroscience |
| title | The superior colliculus directs goal-oriented forelimb movements |
| title_full | The superior colliculus directs goal-oriented forelimb movements |
| title_fullStr | The superior colliculus directs goal-oriented forelimb movements |
| title_full_unstemmed | The superior colliculus directs goal-oriented forelimb movements |
| title_short | The superior colliculus directs goal-oriented forelimb movements |
| title_sort | superior colliculus directs goal oriented forelimb movements |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124724014487 |
| work_keys_str_mv | AT shrivaschaterji thesuperiorcolliculusdirectsgoalorientedforelimbmovements AT punarvahbelliappa thesuperiorcolliculusdirectsgoalorientedforelimbmovements AT anupamasathyamurthy thesuperiorcolliculusdirectsgoalorientedforelimbmovements AT shrivaschaterji superiorcolliculusdirectsgoalorientedforelimbmovements AT punarvahbelliappa superiorcolliculusdirectsgoalorientedforelimbmovements AT anupamasathyamurthy superiorcolliculusdirectsgoalorientedforelimbmovements |