Assessing the prognosis mortality in patients with cutaneous verrucous carcinoma using Lasso-cox regression model: a retrospective study
Abstract Elucidating risk factors and prognostic indicators for cutaneous verrucous carcinoma (CVC) is crucial for rapid medical intervention. This study examined CVC incidence risk and prognostic factors, emphasizing sex disparities. Utilizing SEER Database records, we analyzed patients diagnosed w...
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| Format: | Article |
| Language: | English |
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Springer
2025-06-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-02893-6 |
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| author | Santosh Chokkakula Siomui Chong Yu-Yen Yang Liying Huang Yanan Qian Qixiang Sun Sijian Xia Xiaoxi Zhang Jiang Yong Balaji Pathakumari D. S. Prabakaran In-Cheong Si Yuyi Ou Chengliang Yin |
| author_facet | Santosh Chokkakula Siomui Chong Yu-Yen Yang Liying Huang Yanan Qian Qixiang Sun Sijian Xia Xiaoxi Zhang Jiang Yong Balaji Pathakumari D. S. Prabakaran In-Cheong Si Yuyi Ou Chengliang Yin |
| author_sort | Santosh Chokkakula |
| collection | DOAJ |
| description | Abstract Elucidating risk factors and prognostic indicators for cutaneous verrucous carcinoma (CVC) is crucial for rapid medical intervention. This study examined CVC incidence risk and prognostic factors, emphasizing sex disparities. Utilizing SEER Database records, we analyzed patients diagnosed with primary CVC from 2004 to 2015. Multivariate logistic regression identified risk factors for the incidence model, while multivariate Cox regression developed the mortality prognosis model. Lasso regression and lasso Cox models determined key factors for respective models. Restricted cubic spline (RCS) models measured age-related risk associated with CVC presence and survival. The study included 1,125 CVC patients (668 males, 59.4%; 457 females, 40.6%) at the time of diagnosis. Lasso regression identified independent risk factors including age, sex, race, marital status, AJCC Stage, Combined Summary Stage, radiation, surgery, tumor size, chemotherapy, and regional lymph node involvement. The Age, sex, marital status, AJCC stage, combined summary stage, and surgery were independently associated with overall survival (OS) and statistically significant. Kaplan-Meier analysis revealed significantly shorter OS in female CVC patients compared to males (P < 0.05). The RCS model demonstrated a U-shaped pattern, indicating a significant nonlinear relationship between age and CVC incidence. The current study uncovered sex-related variations in incident risk and mortality prognostic factors, prediction of complications among CVC patients, offering valued insights for healthcare professionals in clinical assessments and interventions. |
| format | Article |
| id | doaj-art-33ef12490432419486f06da9a0c7e71e |
| institution | DOAJ |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-33ef12490432419486f06da9a0c7e71e2025-08-20T02:39:48ZengSpringerDiscover Oncology2730-60112025-06-0116112010.1007/s12672-025-02893-6Assessing the prognosis mortality in patients with cutaneous verrucous carcinoma using Lasso-cox regression model: a retrospective studySantosh Chokkakula0Siomui Chong1Yu-Yen Yang2Liying Huang3Yanan Qian4Qixiang Sun5Sijian Xia6Xiaoxi Zhang7Jiang Yong8Balaji Pathakumari9D. S. Prabakaran10In-Cheong Si11Yuyi Ou12Chengliang Yin13Department of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute CheongjuDepartment of Dermatology, The University of Hong Kong-Shenzhen HospitalDr. Pong Dermatologic and Aesthetic ClinicDepartment of Clinical Research, The First Affiliated Hospital of Jinan UniversityOrthopedic Medicine Faculty, Henan University of Chinese MedicineSchool of Radiology, Shandong First Medical UniversitySchool of Basic Medical Sciences, Capital Medical UniversityDepartment of Dermatology, The First Affiliated Hospital of Jinan University & Jinan University Institute of DermatologyDepartment of Oncology, The University of Hong Kong-Shenzhen HospitalDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo ClinicDepartment of Biotechnology, School of Bio-Engineering, SRM Institute of Science and TechnologyDepartment of Orthopedic, CLINICA DE WONG’SDepartment of Gynaecology, Foshan Women and Children Hospital Affiliated to Guangdong Medical UniversityMedical Innovation Research Department, Chinese PLA General HospitalAbstract Elucidating risk factors and prognostic indicators for cutaneous verrucous carcinoma (CVC) is crucial for rapid medical intervention. This study examined CVC incidence risk and prognostic factors, emphasizing sex disparities. Utilizing SEER Database records, we analyzed patients diagnosed with primary CVC from 2004 to 2015. Multivariate logistic regression identified risk factors for the incidence model, while multivariate Cox regression developed the mortality prognosis model. Lasso regression and lasso Cox models determined key factors for respective models. Restricted cubic spline (RCS) models measured age-related risk associated with CVC presence and survival. The study included 1,125 CVC patients (668 males, 59.4%; 457 females, 40.6%) at the time of diagnosis. Lasso regression identified independent risk factors including age, sex, race, marital status, AJCC Stage, Combined Summary Stage, radiation, surgery, tumor size, chemotherapy, and regional lymph node involvement. The Age, sex, marital status, AJCC stage, combined summary stage, and surgery were independently associated with overall survival (OS) and statistically significant. Kaplan-Meier analysis revealed significantly shorter OS in female CVC patients compared to males (P < 0.05). The RCS model demonstrated a U-shaped pattern, indicating a significant nonlinear relationship between age and CVC incidence. The current study uncovered sex-related variations in incident risk and mortality prognostic factors, prediction of complications among CVC patients, offering valued insights for healthcare professionals in clinical assessments and interventions.https://doi.org/10.1007/s12672-025-02893-6Cutaneous verrucous carcinomaLASSOCox proportional hazardOverall survivalPrognosis prediction |
| spellingShingle | Santosh Chokkakula Siomui Chong Yu-Yen Yang Liying Huang Yanan Qian Qixiang Sun Sijian Xia Xiaoxi Zhang Jiang Yong Balaji Pathakumari D. S. Prabakaran In-Cheong Si Yuyi Ou Chengliang Yin Assessing the prognosis mortality in patients with cutaneous verrucous carcinoma using Lasso-cox regression model: a retrospective study Discover Oncology Cutaneous verrucous carcinoma LASSO Cox proportional hazard Overall survival Prognosis prediction |
| title | Assessing the prognosis mortality in patients with cutaneous verrucous carcinoma using Lasso-cox regression model: a retrospective study |
| title_full | Assessing the prognosis mortality in patients with cutaneous verrucous carcinoma using Lasso-cox regression model: a retrospective study |
| title_fullStr | Assessing the prognosis mortality in patients with cutaneous verrucous carcinoma using Lasso-cox regression model: a retrospective study |
| title_full_unstemmed | Assessing the prognosis mortality in patients with cutaneous verrucous carcinoma using Lasso-cox regression model: a retrospective study |
| title_short | Assessing the prognosis mortality in patients with cutaneous verrucous carcinoma using Lasso-cox regression model: a retrospective study |
| title_sort | assessing the prognosis mortality in patients with cutaneous verrucous carcinoma using lasso cox regression model a retrospective study |
| topic | Cutaneous verrucous carcinoma LASSO Cox proportional hazard Overall survival Prognosis prediction |
| url | https://doi.org/10.1007/s12672-025-02893-6 |
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