Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity
Obesity is a multifactorial condition resulting from improper balances of hormones and gene expression induced by the diet. Obesity also has a strong inflammatory component that can be driven by diet-induced increases in arachidonic acid. The purpose of this paper is to discuss the molecular targe...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2011/431985 |
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| _version_ | 1832563761360142336 |
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| author | Barry Sears Camillo Ricordi |
| author_facet | Barry Sears Camillo Ricordi |
| author_sort | Barry Sears |
| collection | DOAJ |
| description | Obesity is a multifactorial condition resulting from improper balances of hormones and gene expression induced by the diet. Obesity also has a strong inflammatory component that can be driven by diet-induced increases in arachidonic acid. The purpose of this paper is to discuss the molecular targets that can be addressed by anti-inflammatory nutrition. These molecular targets range from reduction of proinflammatory eicosanoids to the modulation of features of the innate immune system, such as toll-like receptors and gene transcription factors. From knowledge of the impact of these dietary nutrients on these various molecular targets, it becomes possible to develop a general outline of an anti-inflammatory diet that can offer a unique synergism with more traditional pharmacological approaches in treating obesity and its associated comorbidities. |
| format | Article |
| id | doaj-art-33eedfaa12ad4f639a1cf3c5a4d28a6f |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-33eedfaa12ad4f639a1cf3c5a4d28a6f2025-02-03T01:12:36ZengWileyJournal of Obesity2090-07082090-07162011-01-01201110.1155/2011/431985431985Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat ObesityBarry Sears0Camillo Ricordi1Inflammation Research Foundation, Marblehead, MA 01945, USADiabetes Research Institute, University of Miami, Miami, FL 33316, USAObesity is a multifactorial condition resulting from improper balances of hormones and gene expression induced by the diet. Obesity also has a strong inflammatory component that can be driven by diet-induced increases in arachidonic acid. The purpose of this paper is to discuss the molecular targets that can be addressed by anti-inflammatory nutrition. These molecular targets range from reduction of proinflammatory eicosanoids to the modulation of features of the innate immune system, such as toll-like receptors and gene transcription factors. From knowledge of the impact of these dietary nutrients on these various molecular targets, it becomes possible to develop a general outline of an anti-inflammatory diet that can offer a unique synergism with more traditional pharmacological approaches in treating obesity and its associated comorbidities.http://dx.doi.org/10.1155/2011/431985 |
| spellingShingle | Barry Sears Camillo Ricordi Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity Journal of Obesity |
| title | Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity |
| title_full | Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity |
| title_fullStr | Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity |
| title_full_unstemmed | Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity |
| title_short | Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity |
| title_sort | anti inflammatory nutrition as a pharmacological approach to treat obesity |
| url | http://dx.doi.org/10.1155/2011/431985 |
| work_keys_str_mv | AT barrysears antiinflammatorynutritionasapharmacologicalapproachtotreatobesity AT camilloricordi antiinflammatorynutritionasapharmacologicalapproachtotreatobesity |