Inhibition of WAC alleviates the chondrocyte proinflammatory secretory phenotype and cartilage degradation via H2BK120ub1 and H3K27me3 coregulation

Inhibition of WAC alleviates the chondrocyte proinflammatory secretory phenotype and cartilage degradation via H2BK120ub1 and H3K27me3 coregulation

Several types of arthritis share the common feature that the generation of inflammatory mediators leads to joint cartilage degradation. However, the shared mechanism is largely unknown. H2BK120ub1 was reportedly involved in various inflammatory diseases but its role in the shared mechanism in inflam...

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Bibliographic Details
Main Authors: Peitao Xu, Guiwen Ye, Xiaojun Xu, Zhidong Liu, Wenhui Yu, Guan Zheng, Zepeng Su, Jiajie Lin, Yunshu Che, Yipeng Zeng, Zhikun Li, Pei Feng, Qian Cao, Zhongyu Xie, Yanfeng Wu, Huiyong Shen, Jinteng Li
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Arthritis
WAC
Cartilage degradation
Chondrocyte secretion
Histone modification
Doxercalciferol
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525004356
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