Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment
In the 21st century, thanks to advances in biotechnology and developing pharmaceutical technology, significant progress is being made in effective drug design. Drug targeting aims to ensure that the drug acts only in the pathological area; it is defined as the ability to accumulate selectively and q...
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| Format: | Article |
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2025-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/17/1/121 |
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| author | Fatih Ciftci Ali Can Özarslan İmran Cagri Kantarci Aslihan Yelkenci Ozlem Tavukcuoglu Mansour Ghorbanpour |
| author_facet | Fatih Ciftci Ali Can Özarslan İmran Cagri Kantarci Aslihan Yelkenci Ozlem Tavukcuoglu Mansour Ghorbanpour |
| author_sort | Fatih Ciftci |
| collection | DOAJ |
| description | In the 21st century, thanks to advances in biotechnology and developing pharmaceutical technology, significant progress is being made in effective drug design. Drug targeting aims to ensure that the drug acts only in the pathological area; it is defined as the ability to accumulate selectively and quantitatively in the target tissue or organ, regardless of the chemical structure of the active drug substance and the method of administration. With drug targeting, conventional, biotechnological and gene-derived drugs target the body’s organs, tissues, and cells that can be selectively transported to specific regions. These systems serve as drug carriers and regulate the timing of release. Despite having many advantageous features, these systems have limitations in thoroughly treating complex diseases such as cancer. Therefore, combining these systems with nanoparticle technologies is imperative to treat cancer at both local and systemic levels effectively. The nanocarrier-based drug delivery method involves encapsulating target-specific drug molecules into polymeric or vesicular systems. Various drug delivery systems (DDS) were investigated and discussed in this review article. The first part discussed active and passive delivery systems, hydrogels, thermoplastics, microdevices and transdermal-based drug delivery systems. The second part discussed drug carrier systems in nanobiotechnology (carbon nanotubes, nanoparticles, coated, pegylated, solid lipid nanoparticles and smart polymeric nanogels). In the third part, drug targeting advantages were discussed, and finally, market research of commercial drugs used in cancer nanotechnological approaches was included. |
| format | Article |
| id | doaj-art-33ea59aec0ce4f3491545269793d808e |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-33ea59aec0ce4f3491545269793d808e2025-01-24T13:46:02ZengMDPI AGPharmaceutics1999-49232025-01-0117112110.3390/pharmaceutics17010121Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer TreatmentFatih Ciftci0Ali Can Özarslan1İmran Cagri Kantarci2Aslihan Yelkenci3Ozlem Tavukcuoglu4Mansour Ghorbanpour5Department of Biomedical Engineering, Faculty of Engineering, Fatih Sultan Mehmet Vakıf University, Istanbul 34015, TurkeyDepartment of Metallurgical and Materials Engineering, Istanbul University-Cerrahpasa, Istanbul 34320, TurkeyDepartment of Bioengineering, Faculty of Chemistry-Metallurgy, Yildiz Technical University, Istanbul 34210, TurkeyDepartment of Pediatric Dentistry, Faculty of Dentistry, University of Health Sciences, Istanbul 34668, TurkeyDepartment of Biochemistry, Faculty of Hamidiye Pharmacy, University of Health Sciences, Istanbul 34668, TurkeyDepartment of Medicinal Plants, Faculty of Agriculture and Natural Resources, Arak University, Arak 38156-8-8349, IranIn the 21st century, thanks to advances in biotechnology and developing pharmaceutical technology, significant progress is being made in effective drug design. Drug targeting aims to ensure that the drug acts only in the pathological area; it is defined as the ability to accumulate selectively and quantitatively in the target tissue or organ, regardless of the chemical structure of the active drug substance and the method of administration. With drug targeting, conventional, biotechnological and gene-derived drugs target the body’s organs, tissues, and cells that can be selectively transported to specific regions. These systems serve as drug carriers and regulate the timing of release. Despite having many advantageous features, these systems have limitations in thoroughly treating complex diseases such as cancer. Therefore, combining these systems with nanoparticle technologies is imperative to treat cancer at both local and systemic levels effectively. The nanocarrier-based drug delivery method involves encapsulating target-specific drug molecules into polymeric or vesicular systems. Various drug delivery systems (DDS) were investigated and discussed in this review article. The first part discussed active and passive delivery systems, hydrogels, thermoplastics, microdevices and transdermal-based drug delivery systems. The second part discussed drug carrier systems in nanobiotechnology (carbon nanotubes, nanoparticles, coated, pegylated, solid lipid nanoparticles and smart polymeric nanogels). In the third part, drug targeting advantages were discussed, and finally, market research of commercial drugs used in cancer nanotechnological approaches was included.https://www.mdpi.com/1999-4923/17/1/121drug carriersdrug delivery systemsdrug targetingnanotechnology |
| spellingShingle | Fatih Ciftci Ali Can Özarslan İmran Cagri Kantarci Aslihan Yelkenci Ozlem Tavukcuoglu Mansour Ghorbanpour Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment Pharmaceutics drug carriers drug delivery systems drug targeting nanotechnology |
| title | Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment |
| title_full | Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment |
| title_fullStr | Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment |
| title_full_unstemmed | Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment |
| title_short | Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment |
| title_sort | advances in drug targeting drug delivery and nanotechnology applications therapeutic significance in cancer treatment |
| topic | drug carriers drug delivery systems drug targeting nanotechnology |
| url | https://www.mdpi.com/1999-4923/17/1/121 |
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