D-stem mutation in an essential tRNA increases translation speed at the cost of fidelity.

D-stem mutation in an essential tRNA increases translation speed at the cost of fidelity.

The efficiency with which aminoacyl-tRNA and GTP-bound translation elongation factor EF-Tu recognizes the A-site codon of the ribosome is dependent on codons and tRNA species present in the polypeptide (P) and exit (E) codon sites. To understand how codon context affects the efficiency of codon reco...

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Bibliographic Details
Main Authors: Madison N Schrock, Krishna Parsawar, Kelly T Hughes, Fabienne F V Chevance
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-02-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011569
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