Correlation between gastric acid secretion and severity of acid reflux in children
The purpose of our study was to systematically evaluate gastric acid output in children with long-lasting gastro-esophageal reflux (GER) in order to assess its mechanism and the need for anti-acid treatment. The investigation was carried out in 20 males and 10 females, aged 7.5 +/- 3.8 years,...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2003-01-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/2845 |
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| author | Nicolas Kalach Abdul Monem Badran Patrick Jaffray Florence Campeotto Pierre Henri Benhamou Christophe Dupont |
| author_facet | Nicolas Kalach Abdul Monem Badran Patrick Jaffray Florence Campeotto Pierre Henri Benhamou Christophe Dupont |
| author_sort | Nicolas Kalach |
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The purpose of our study was to systematically evaluate gastric acid output in children with long-lasting gastro-esophageal reflux (GER) in order to assess its mechanism and the need for anti-acid treatment. The investigation was carried out in 20 males and 10 females, aged 7.5 +/- 3.8 years, with prolonged (>15 months) clinical manifestations of GER. All underwent routine ambulatory 24-h esophageal pH-monitoring and measurement of gastric acid secretion including gastric basal (BAO) (micromol/kg/h), maximal (MAO) and peak acid outputs (PAO) after pentagastrin (6 microg/kg sec) stimulation. Children with heartburn or abdominal pain underwent upper fiber-endoscopy. In group A (moderate GER, n=12), patients had a normal reflux index (pH5.2%. When considering all children, esophageal pH (%) was significantly correlated with MAO and PAO, r=0.33, p=0.05 and r=0.37, p=0.04, respectively. Children of group B exhibited significantly higher BAO (75, 53.96-137.81), MAO (468, 394.1-671.3) and PAO (617, 518.8-782.3) than those of group A, BAO (27, 10.8-38.5), MAO (266, 243.2-348.2) and PAO (387, 322.5-452.7), p |
| format | Article |
| id | doaj-art-33e282a192b74ebf9a3ba9b4b1aa2bda |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-33e282a192b74ebf9a3ba9b4b1aa2bda2025-08-20T02:01:54ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212003-01-01451Correlation between gastric acid secretion and severity of acid reflux in childrenNicolas Kalach0Abdul Monem BadranPatrick JaffrayFlorence CampeottoPierre Henri BenhamouChristophe DupontDepartment of Pediatrics, Hôpital Cochin-Saint Vincent de Paul, Paris, France. The purpose of our study was to systematically evaluate gastric acid output in children with long-lasting gastro-esophageal reflux (GER) in order to assess its mechanism and the need for anti-acid treatment. The investigation was carried out in 20 males and 10 females, aged 7.5 +/- 3.8 years, with prolonged (>15 months) clinical manifestations of GER. All underwent routine ambulatory 24-h esophageal pH-monitoring and measurement of gastric acid secretion including gastric basal (BAO) (micromol/kg/h), maximal (MAO) and peak acid outputs (PAO) after pentagastrin (6 microg/kg sec) stimulation. Children with heartburn or abdominal pain underwent upper fiber-endoscopy. In group A (moderate GER, n=12), patients had a normal reflux index (pH5.2%. When considering all children, esophageal pH (%) was significantly correlated with MAO and PAO, r=0.33, p=0.05 and r=0.37, p=0.04, respectively. Children of group B exhibited significantly higher BAO (75, 53.96-137.81), MAO (468, 394.1-671.3) and PAO (617, 518.8-782.3) than those of group A, BAO (27, 10.8-38.5), MAO (266, 243.2-348.2) and PAO (387, 322.5-452.7), phttps://turkjpediatr.org/article/view/2845 |
| spellingShingle | Nicolas Kalach Abdul Monem Badran Patrick Jaffray Florence Campeotto Pierre Henri Benhamou Christophe Dupont Correlation between gastric acid secretion and severity of acid reflux in children The Turkish Journal of Pediatrics |
| title | Correlation between gastric acid secretion and severity of acid reflux in children |
| title_full | Correlation between gastric acid secretion and severity of acid reflux in children |
| title_fullStr | Correlation between gastric acid secretion and severity of acid reflux in children |
| title_full_unstemmed | Correlation between gastric acid secretion and severity of acid reflux in children |
| title_short | Correlation between gastric acid secretion and severity of acid reflux in children |
| title_sort | correlation between gastric acid secretion and severity of acid reflux in children |
| url | https://turkjpediatr.org/article/view/2845 |
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