mTORC1-selective inhibitors rescue cellular phenotypes in TSC iPSC-derived neurons

mTORC1-selective inhibitors rescue cellular phenotypes in TSC iPSC-derived neurons

The mechanistic target of rapamycin (mTOR) pathway plays an important role in regulating multiple cellular processes, including cell growth, autophagy, proliferation, protein synthesis, and lipid synthesis, among others. Given the central role of this pathway in multiple cellular processes, it is no...

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Bibliographic Details
Main Authors: Elizabeth D. Buttermore, Gayathri Rajaram Srinivasan, Hellen Jumo, Amanda C. Swanson, Benjamin O’Kelly, Nina R. Makhortova, Mustafa Sahin, Stelios T. Tzannis
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Neuroscience
Subjects:
mTORC1
mTORC2
iPSC-derived neurons
TSC2
mTOR
hyperexcitability
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1595880/full
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