Chelating Properties of N<sub>6</sub>O-Donors Toward Cu(II) Ions: Speciation in Aqueous Environments and Catalytic Activity of the Dinuclear Complexes
This study focuses on the use of three isostructural N<sub>6</sub>O donor ligands, specifically known to form complexes with copper ions, to chelate Cu(II) from aqueous solutions. The corresponding Cu(II) complexes feature a dinuclear copper core mimicking the active site of natural supe...
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| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/29/23/5708 |
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| author | Andrea Cendron Martina Chianese Kamil Zarzycki Paolo Ruzza Claudia Honisch Justyna Brasuń Mauro Carraro |
| author_facet | Andrea Cendron Martina Chianese Kamil Zarzycki Paolo Ruzza Claudia Honisch Justyna Brasuń Mauro Carraro |
| author_sort | Andrea Cendron |
| collection | DOAJ |
| description | This study focuses on the use of three isostructural N<sub>6</sub>O donor ligands, specifically known to form complexes with copper ions, to chelate Cu(II) from aqueous solutions. The corresponding Cu(II) complexes feature a dinuclear copper core mimicking the active site of natural superoxide dismutase (SOD) enzymes while also creating a coordination environment favorable for catalase (CAT) activity, being thus appealing as catalytic antioxidant systems. Given the critical role of copper dysregulation in the pathophysiology of Alzheimer’s disease (AD), these complexes may help mitigate the harmful effects of free Cu(II) ions: the goal is to transform copper’s reactive oxygen species (ROS)-generating properties into beneficial ROS-scavenging action. This study investigates the speciation, chelating efficiency, and metal selectivity of these ligands, as well as the antioxidant activity of the resulting complexes under aqueous and physiologically relevant conditions. Additionally, the ligands, equipped with functional groups for attaching targeting moieties, are conjugated with a small peptide that may act as an anti-aggregating agent of β-amyloid peptides, aiming to develop a multifunctional therapeutic strategy against Alzheimer’s disease. |
| format | Article |
| id | doaj-art-33dd4da3359a4253a86f1f1eff3443b1 |
| institution | DOAJ |
| issn | 1420-3049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-33dd4da3359a4253a86f1f1eff3443b12025-08-20T02:50:34ZengMDPI AGMolecules1420-30492024-12-012923570810.3390/molecules29235708Chelating Properties of N<sub>6</sub>O-Donors Toward Cu(II) Ions: Speciation in Aqueous Environments and Catalytic Activity of the Dinuclear ComplexesAndrea Cendron0Martina Chianese1Kamil Zarzycki2Paolo Ruzza3Claudia Honisch4Justyna Brasuń5Mauro Carraro6Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131 Padova, ItalyDepartment of Chemical Sciences, University of Padova, Via Marzolo 1, 35131 Padova, ItalyBiomolecule Student Science Club, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, PolandInstitute of Biomolecular Chemistry of CNR (ICB-CNR), Padova, Via Marzolo 1, 35131 Padova, ItalyInstitute of Biomolecular Chemistry of CNR (ICB-CNR), Padova, Via Marzolo 1, 35131 Padova, ItalyDepartment of the Basic Chemical Sciences, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Chemical Sciences, University of Padova, Via Marzolo 1, 35131 Padova, ItalyThis study focuses on the use of three isostructural N<sub>6</sub>O donor ligands, specifically known to form complexes with copper ions, to chelate Cu(II) from aqueous solutions. The corresponding Cu(II) complexes feature a dinuclear copper core mimicking the active site of natural superoxide dismutase (SOD) enzymes while also creating a coordination environment favorable for catalase (CAT) activity, being thus appealing as catalytic antioxidant systems. Given the critical role of copper dysregulation in the pathophysiology of Alzheimer’s disease (AD), these complexes may help mitigate the harmful effects of free Cu(II) ions: the goal is to transform copper’s reactive oxygen species (ROS)-generating properties into beneficial ROS-scavenging action. This study investigates the speciation, chelating efficiency, and metal selectivity of these ligands, as well as the antioxidant activity of the resulting complexes under aqueous and physiologically relevant conditions. Additionally, the ligands, equipped with functional groups for attaching targeting moieties, are conjugated with a small peptide that may act as an anti-aggregating agent of β-amyloid peptides, aiming to develop a multifunctional therapeutic strategy against Alzheimer’s disease.https://www.mdpi.com/1420-3049/29/23/5708copperSOD activitycatalase activityperoxidase activityligandschelators |
| spellingShingle | Andrea Cendron Martina Chianese Kamil Zarzycki Paolo Ruzza Claudia Honisch Justyna Brasuń Mauro Carraro Chelating Properties of N<sub>6</sub>O-Donors Toward Cu(II) Ions: Speciation in Aqueous Environments and Catalytic Activity of the Dinuclear Complexes Molecules copper SOD activity catalase activity peroxidase activity ligands chelators |
| title | Chelating Properties of N<sub>6</sub>O-Donors Toward Cu(II) Ions: Speciation in Aqueous Environments and Catalytic Activity of the Dinuclear Complexes |
| title_full | Chelating Properties of N<sub>6</sub>O-Donors Toward Cu(II) Ions: Speciation in Aqueous Environments and Catalytic Activity of the Dinuclear Complexes |
| title_fullStr | Chelating Properties of N<sub>6</sub>O-Donors Toward Cu(II) Ions: Speciation in Aqueous Environments and Catalytic Activity of the Dinuclear Complexes |
| title_full_unstemmed | Chelating Properties of N<sub>6</sub>O-Donors Toward Cu(II) Ions: Speciation in Aqueous Environments and Catalytic Activity of the Dinuclear Complexes |
| title_short | Chelating Properties of N<sub>6</sub>O-Donors Toward Cu(II) Ions: Speciation in Aqueous Environments and Catalytic Activity of the Dinuclear Complexes |
| title_sort | chelating properties of n sub 6 sub o donors toward cu ii ions speciation in aqueous environments and catalytic activity of the dinuclear complexes |
| topic | copper SOD activity catalase activity peroxidase activity ligands chelators |
| url | https://www.mdpi.com/1420-3049/29/23/5708 |
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