Ivosidenib – Another feather in the hat of treatment for acute myeloid leukemia
The treatment of acute myeloid leukemia has undergone a paradigm shift in the past few years. Multiple new targeted and nontargeted agents have been approved in the recent past. Isocitrate dehydrogenase (IDH) mutation is one such target that has been identified, and two new drugs, ivosidenib and ena...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2020-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2020;volume=41;issue=4;spage=552;epage=554;aulast=Perumal |
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| _version_ | 1850043207616823296 |
|---|---|
| author | Jayachandran Perumal Kalaiyarasi |
| author_facet | Jayachandran Perumal Kalaiyarasi |
| author_sort | Jayachandran Perumal Kalaiyarasi |
| collection | DOAJ |
| description | The treatment of acute myeloid leukemia has undergone a paradigm shift in the past few years. Multiple new targeted and nontargeted agents have been approved in the recent past. Isocitrate dehydrogenase (IDH) mutation is one such target that has been identified, and two new drugs, ivosidenib and enasidenib have been approved. The former is an IDH1 inhibitor, and the latter is an IDH2 inhibitor. The mechanism of action, key trials, adverse events, and monitoring of ivosidenib has been discussed in this article. |
| format | Article |
| id | doaj-art-33dd2287e7a64ecbbb021f0f479ef903 |
| institution | DOAJ |
| issn | 0971-5851 0975-2129 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-33dd2287e7a64ecbbb021f0f479ef9032025-08-20T02:55:17ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-21292020-01-0141455255410.4103/ijmpo.ijmpo_81_20Ivosidenib – Another feather in the hat of treatment for acute myeloid leukemiaJayachandran Perumal KalaiyarasiThe treatment of acute myeloid leukemia has undergone a paradigm shift in the past few years. Multiple new targeted and nontargeted agents have been approved in the recent past. Isocitrate dehydrogenase (IDH) mutation is one such target that has been identified, and two new drugs, ivosidenib and enasidenib have been approved. The former is an IDH1 inhibitor, and the latter is an IDH2 inhibitor. The mechanism of action, key trials, adverse events, and monitoring of ivosidenib has been discussed in this article.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2020;volume=41;issue=4;spage=552;epage=554;aulast=Perumalisocitrate dehydrogenase inhibitorsivosidenibnew drugs in acute myeloid leukemia |
| spellingShingle | Jayachandran Perumal Kalaiyarasi Ivosidenib – Another feather in the hat of treatment for acute myeloid leukemia Indian Journal of Medical and Paediatric Oncology isocitrate dehydrogenase inhibitors ivosidenib new drugs in acute myeloid leukemia |
| title | Ivosidenib – Another feather in the hat of treatment for acute myeloid leukemia |
| title_full | Ivosidenib – Another feather in the hat of treatment for acute myeloid leukemia |
| title_fullStr | Ivosidenib – Another feather in the hat of treatment for acute myeloid leukemia |
| title_full_unstemmed | Ivosidenib – Another feather in the hat of treatment for acute myeloid leukemia |
| title_short | Ivosidenib – Another feather in the hat of treatment for acute myeloid leukemia |
| title_sort | ivosidenib another feather in the hat of treatment for acute myeloid leukemia |
| topic | isocitrate dehydrogenase inhibitors ivosidenib new drugs in acute myeloid leukemia |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2020;volume=41;issue=4;spage=552;epage=554;aulast=Perumal |
| work_keys_str_mv | AT jayachandranperumalkalaiyarasi ivosidenibanotherfeatherinthehatoftreatmentforacutemyeloidleukemia |