Association between Red Blood Cell Distribution Width and Diabetic Retinopathy: A 5-Year Retrospective Case-Control Study
Purpose. Red blood cell distribution width (RDW) has been regarded as an emerging biomarker of the general population and cardiovascular disease. In this study, we aimed to evaluate the association between RDW and diabetic retinopathy (DR). Methods. This case-control study included 167 patients with...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2021/6653969 |
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| author | Yingbo Ma Shengjie Li Aiping Zhang Yi Ma Yani Wan Jianping Han Wenjun Cao Gezhi Xu |
| author_facet | Yingbo Ma Shengjie Li Aiping Zhang Yi Ma Yani Wan Jianping Han Wenjun Cao Gezhi Xu |
| author_sort | Yingbo Ma |
| collection | DOAJ |
| description | Purpose. Red blood cell distribution width (RDW) has been regarded as an emerging biomarker of the general population and cardiovascular disease. In this study, we aimed to evaluate the association between RDW and diabetic retinopathy (DR). Methods. This case-control study included 167 patients with DR, 131 patients with diabetes mellitus (DM), and 170 age- and sex-matched healthy controls from April 2014 to May 2019. Demographic data, laboratory parameters, and ocular examinations were collected. Results. RDW values of the DR group were significantly higher than those of the healthy control (p<0.001) and DM group (p=0.002). A similar trend was observed when RDW was compared among the 3 groups with respect to age and gender. Logistic regression analysis has shown the OR of RDW was 3.791 (2.33–6.168; p<0.001) against the control group and was 1.348 (0.997–1.823; p=0.047) against the DM group. Conclusion. RDW values were significantly elevated in DR patients, and an elevated RDW was associated with an increased incidence of DR in patients with DM. |
| format | Article |
| id | doaj-art-33d91ef8a93b401dadc1a7163f9227f8 |
| institution | OA Journals |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-33d91ef8a93b401dadc1a7163f9227f82025-08-20T02:24:15ZengWileyJournal of Ophthalmology2090-004X2090-00582021-01-01202110.1155/2021/66539696653969Association between Red Blood Cell Distribution Width and Diabetic Retinopathy: A 5-Year Retrospective Case-Control StudyYingbo Ma0Shengjie Li1Aiping Zhang2Yi Ma3Yani Wan4Jianping Han5Wenjun Cao6Gezhi Xu7Department of Clinical Laboratory, Eye and ENT Hospital of Fudan University, Shanghai, ChinaDepartment of Clinical Laboratory, Eye and ENT Hospital of Fudan University, Shanghai, ChinaDepartment of Clinical Laboratory, Eye and ENT Hospital of Fudan University, Shanghai, ChinaDepartment of Clinical Laboratory, Eye and ENT Hospital of Fudan University, Shanghai, ChinaDepartment of Clinical Laboratory, Eye and ENT Hospital of Fudan University, Shanghai, ChinaDepartment of Clinical Laboratory, Eye and ENT Hospital of Fudan University, Shanghai, ChinaDepartment of Clinical Laboratory, Eye and ENT Hospital of Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, ChinaPurpose. Red blood cell distribution width (RDW) has been regarded as an emerging biomarker of the general population and cardiovascular disease. In this study, we aimed to evaluate the association between RDW and diabetic retinopathy (DR). Methods. This case-control study included 167 patients with DR, 131 patients with diabetes mellitus (DM), and 170 age- and sex-matched healthy controls from April 2014 to May 2019. Demographic data, laboratory parameters, and ocular examinations were collected. Results. RDW values of the DR group were significantly higher than those of the healthy control (p<0.001) and DM group (p=0.002). A similar trend was observed when RDW was compared among the 3 groups with respect to age and gender. Logistic regression analysis has shown the OR of RDW was 3.791 (2.33–6.168; p<0.001) against the control group and was 1.348 (0.997–1.823; p=0.047) against the DM group. Conclusion. RDW values were significantly elevated in DR patients, and an elevated RDW was associated with an increased incidence of DR in patients with DM.http://dx.doi.org/10.1155/2021/6653969 |
| spellingShingle | Yingbo Ma Shengjie Li Aiping Zhang Yi Ma Yani Wan Jianping Han Wenjun Cao Gezhi Xu Association between Red Blood Cell Distribution Width and Diabetic Retinopathy: A 5-Year Retrospective Case-Control Study Journal of Ophthalmology |
| title | Association between Red Blood Cell Distribution Width and Diabetic Retinopathy: A 5-Year Retrospective Case-Control Study |
| title_full | Association between Red Blood Cell Distribution Width and Diabetic Retinopathy: A 5-Year Retrospective Case-Control Study |
| title_fullStr | Association between Red Blood Cell Distribution Width and Diabetic Retinopathy: A 5-Year Retrospective Case-Control Study |
| title_full_unstemmed | Association between Red Blood Cell Distribution Width and Diabetic Retinopathy: A 5-Year Retrospective Case-Control Study |
| title_short | Association between Red Blood Cell Distribution Width and Diabetic Retinopathy: A 5-Year Retrospective Case-Control Study |
| title_sort | association between red blood cell distribution width and diabetic retinopathy a 5 year retrospective case control study |
| url | http://dx.doi.org/10.1155/2021/6653969 |
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