Mitochondrial DNA as a Factor of Glaucomous Optic Neuropathy’s Development Mechanism
Currently, the mitochondrial component is becoming increasingly significant in the development and progression of glaucoma optic neuropathy. Since mitochondria have their own genetic apparatus, the study of qualitative and quantitative changes in mitochondrial DNA (mtDNA) becomes part of the disease...
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| Format: | Article |
| Language: | Russian |
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Ophthalmology Publishing Group
2019-12-01
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| Series: | Oftalʹmologiâ |
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| Online Access: | https://www.ophthalmojournal.com/opht/article/view/1081 |
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| author | I. R. Gazizova I. O. Mazunin T. N. Malishevskaya O. A. Kiseleva A. M. Gadzhiev Al.-M. Rindzhibal |
| author_facet | I. R. Gazizova I. O. Mazunin T. N. Malishevskaya O. A. Kiseleva A. M. Gadzhiev Al.-M. Rindzhibal |
| author_sort | I. R. Gazizova |
| collection | DOAJ |
| description | Currently, the mitochondrial component is becoming increasingly significant in the development and progression of glaucoma optic neuropathy. Since mitochondria have their own genetic apparatus, the study of qualitative and quantitative changes in mitochondrial DNA (mtDNA) becomes part of the disease diagnosis, in addition to studying the functional characteristics of the organelles alone. Moreover, the inability to explain the nature of the disease by known mutations of nuclear DNA contributes to the the study of mtDNA. In this review, we briefly discuss the mitochondrial genetics and the role of mitochondrial haplogroups in the diseases manifestation. We summarize the accumulated data on the qualitative and quantitative changes in mtDNA in patients with glaucoma. We discuss the approach to prevent the inheritance of mutant mtDNA as a part of assisted reproductive technologies, as well as the first steps towards the mtDNA heteroplasmy level manipulation and direct mtDNA editing. |
| format | Article |
| id | doaj-art-33d554669aef44a4bedb0e4e6290906e |
| institution | DOAJ |
| issn | 1816-5095 2500-0845 |
| language | Russian |
| publishDate | 2019-12-01 |
| publisher | Ophthalmology Publishing Group |
| record_format | Article |
| series | Oftalʹmologiâ |
| spelling | doaj-art-33d554669aef44a4bedb0e4e6290906e2025-08-20T02:56:15ZrusOphthalmology Publishing GroupOftalʹmologiâ1816-50952500-08452019-12-0116447948610.18008/1816-5095-2019-4-479-486582Mitochondrial DNA as a Factor of Glaucomous Optic Neuropathy’s Development MechanismI. R. Gazizova0I. O. Mazunin1T. N. Malishevskaya2O. A. Kiseleva3A. M. Gadzhiev4Al.-M. Rindzhibal5Institute of Experimental MedicineCenter for Genomic Research, Immanuel Kant Baltic Federal UniversityHelmholtz National medical center of Eye DiseasesHelmholtz National medical center of Eye DiseasesState instituition of health care of Leningrad region “Vsevolozhsk clinical interdistrict hospital”Institute of Experimental MedicineCurrently, the mitochondrial component is becoming increasingly significant in the development and progression of glaucoma optic neuropathy. Since mitochondria have their own genetic apparatus, the study of qualitative and quantitative changes in mitochondrial DNA (mtDNA) becomes part of the disease diagnosis, in addition to studying the functional characteristics of the organelles alone. Moreover, the inability to explain the nature of the disease by known mutations of nuclear DNA contributes to the the study of mtDNA. In this review, we briefly discuss the mitochondrial genetics and the role of mitochondrial haplogroups in the diseases manifestation. We summarize the accumulated data on the qualitative and quantitative changes in mtDNA in patients with glaucoma. We discuss the approach to prevent the inheritance of mutant mtDNA as a part of assisted reproductive technologies, as well as the first steps towards the mtDNA heteroplasmy level manipulation and direct mtDNA editing.https://www.ophthalmojournal.com/opht/article/view/1081glaucoma optic neuropathyprimary open-angle glaucomamitochondrial dysfunctionmitochondrial geneticsmitochondrial dna (mtdna)mitochondrial haplogroupsmtdna mutations correctionmitochondrial oxidative stress |
| spellingShingle | I. R. Gazizova I. O. Mazunin T. N. Malishevskaya O. A. Kiseleva A. M. Gadzhiev Al.-M. Rindzhibal Mitochondrial DNA as a Factor of Glaucomous Optic Neuropathy’s Development Mechanism Oftalʹmologiâ glaucoma optic neuropathy primary open-angle glaucoma mitochondrial dysfunction mitochondrial genetics mitochondrial dna (mtdna) mitochondrial haplogroups mtdna mutations correction mitochondrial oxidative stress |
| title | Mitochondrial DNA as a Factor of Glaucomous Optic Neuropathy’s Development Mechanism |
| title_full | Mitochondrial DNA as a Factor of Glaucomous Optic Neuropathy’s Development Mechanism |
| title_fullStr | Mitochondrial DNA as a Factor of Glaucomous Optic Neuropathy’s Development Mechanism |
| title_full_unstemmed | Mitochondrial DNA as a Factor of Glaucomous Optic Neuropathy’s Development Mechanism |
| title_short | Mitochondrial DNA as a Factor of Glaucomous Optic Neuropathy’s Development Mechanism |
| title_sort | mitochondrial dna as a factor of glaucomous optic neuropathy s development mechanism |
| topic | glaucoma optic neuropathy primary open-angle glaucoma mitochondrial dysfunction mitochondrial genetics mitochondrial dna (mtdna) mitochondrial haplogroups mtdna mutations correction mitochondrial oxidative stress |
| url | https://www.ophthalmojournal.com/opht/article/view/1081 |
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