EFFICACY AND SAFETY OF THE NOVEL ORAL ANTICOAGULANTS FOR PREVENTION OF STROKE AND SYSTEMIC EMBOLISM IN ATRIAL FIBRILLATION
Atrial fibrillation (AF) is one of the most prevalent rhythm disorders and might be associated with the high risk of thromboembolic complications, including stroke. For risk estimation, of the thrombotic complications, a variety of scores has been implemented, including CHA2DS2-VASc Score. According...
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«FIRMA «SILICEA» LLC
2017-07-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/2473 |
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| author | S. K. Zyryanov A. P. Pereverzev |
| author_facet | S. K. Zyryanov A. P. Pereverzev |
| author_sort | S. K. Zyryanov |
| collection | DOAJ |
| description | Atrial fibrillation (AF) is one of the most prevalent rhythm disorders and might be associated with the high risk of thromboembolic complications, including stroke. For risk estimation, of the thrombotic complications, a variety of scores has been implemented, including CHA2DS2-VASc Score. According to the European Society of Cardiology Guidelines on AF management (2016), males showing more than 2 points, and females with more than 3 points by CHA2DS2-VASc, for embolism prevention, it is recommended to prescribe novel oral anticoagulants (NOAC). NOAC are effective and relatively safe comparing to vitamin K antagonists (VKA), are convenient being taken per os, do not have necessity of individual dosing, have rapid onset of the maximum effect (in several hours) and predictable effect in relation to dose. Among drugs from this group, dabigatran can be highlighted, which has in comparative studies shown not only high efficacy, but is the safest among all NOAC, as it does rarely lead to hemorrhagic complications and is the only NOAC for now, with the developed and available neutralizing agent — idarucizumab. |
| format | Article |
| id | doaj-art-33d497d8ae20489c9c34686e3e65b7e2 |
| institution | DOAJ |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2017-07-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-33d497d8ae20489c9c34686e3e65b7e22025-08-20T03:21:09Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202017-07-010615816310.15829/1560-4071-2017-6-158-1632204EFFICACY AND SAFETY OF THE NOVEL ORAL ANTICOAGULANTS FOR PREVENTION OF STROKE AND SYSTEMIC EMBOLISM IN ATRIAL FIBRILLATIONS. K. Zyryanov0A. P. Pereverzev1Peoples’ Friendship University of RussiaPeoples’ Friendship University of RussiaAtrial fibrillation (AF) is one of the most prevalent rhythm disorders and might be associated with the high risk of thromboembolic complications, including stroke. For risk estimation, of the thrombotic complications, a variety of scores has been implemented, including CHA2DS2-VASc Score. According to the European Society of Cardiology Guidelines on AF management (2016), males showing more than 2 points, and females with more than 3 points by CHA2DS2-VASc, for embolism prevention, it is recommended to prescribe novel oral anticoagulants (NOAC). NOAC are effective and relatively safe comparing to vitamin K antagonists (VKA), are convenient being taken per os, do not have necessity of individual dosing, have rapid onset of the maximum effect (in several hours) and predictable effect in relation to dose. Among drugs from this group, dabigatran can be highlighted, which has in comparative studies shown not only high efficacy, but is the safest among all NOAC, as it does rarely lead to hemorrhagic complications and is the only NOAC for now, with the developed and available neutralizing agent — idarucizumab.https://russjcardiol.elpub.ru/jour/article/view/2473strokepreventionnoacefficacysafety |
| spellingShingle | S. K. Zyryanov A. P. Pereverzev EFFICACY AND SAFETY OF THE NOVEL ORAL ANTICOAGULANTS FOR PREVENTION OF STROKE AND SYSTEMIC EMBOLISM IN ATRIAL FIBRILLATION Российский кардиологический журнал stroke prevention noac efficacy safety |
| title | EFFICACY AND SAFETY OF THE NOVEL ORAL ANTICOAGULANTS FOR PREVENTION OF STROKE AND SYSTEMIC EMBOLISM IN ATRIAL FIBRILLATION |
| title_full | EFFICACY AND SAFETY OF THE NOVEL ORAL ANTICOAGULANTS FOR PREVENTION OF STROKE AND SYSTEMIC EMBOLISM IN ATRIAL FIBRILLATION |
| title_fullStr | EFFICACY AND SAFETY OF THE NOVEL ORAL ANTICOAGULANTS FOR PREVENTION OF STROKE AND SYSTEMIC EMBOLISM IN ATRIAL FIBRILLATION |
| title_full_unstemmed | EFFICACY AND SAFETY OF THE NOVEL ORAL ANTICOAGULANTS FOR PREVENTION OF STROKE AND SYSTEMIC EMBOLISM IN ATRIAL FIBRILLATION |
| title_short | EFFICACY AND SAFETY OF THE NOVEL ORAL ANTICOAGULANTS FOR PREVENTION OF STROKE AND SYSTEMIC EMBOLISM IN ATRIAL FIBRILLATION |
| title_sort | efficacy and safety of the novel oral anticoagulants for prevention of stroke and systemic embolism in atrial fibrillation |
| topic | stroke prevention noac efficacy safety |
| url | https://russjcardiol.elpub.ru/jour/article/view/2473 |
| work_keys_str_mv | AT skzyryanov efficacyandsafetyofthenoveloralanticoagulantsforpreventionofstrokeandsystemicembolisminatrialfibrillation AT appereverzev efficacyandsafetyofthenoveloralanticoagulantsforpreventionofstrokeandsystemicembolisminatrialfibrillation |