The association between eight complete blood count-derived inflammatory markers and muscle health
BackgroundMost studies have evaluated sarcopenia and muscle health solely based on muscle mass. This study comprehensively examined the associations between eight inflammatory indicators and muscle mass and strength, with the aim of identifying an indicator capable of evaluating muscle health across...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1498757/full |
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| author | Jingyuan Zhang Yuqi Wang Heng Liu Zhuolin Lei Shouquan Cheng Hong Cao |
| author_facet | Jingyuan Zhang Yuqi Wang Heng Liu Zhuolin Lei Shouquan Cheng Hong Cao |
| author_sort | Jingyuan Zhang |
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| description | BackgroundMost studies have evaluated sarcopenia and muscle health solely based on muscle mass. This study comprehensively examined the associations between eight inflammatory indicators and muscle mass and strength, with the aim of identifying an indicator capable of evaluating muscle health across multiple dimensions.MethodsThis study included 10,440 participants from the National Health and Nutrition Examination Survey (NHANES, 2011–2018) and 5,384 participants from NHANES (2011–2014). Multivariate logistic regression, smooth curve fitting, restricted cubic spline (RCS) analysis, subgroup analysis, and Spearman's correlation were used to comprehensively assess the associations between the eight inflammatory indicators and muscle mass and strength. Receiver operating characteristic (ROC) curves were used to compare the predictive abilities of the different indices for low muscle mass and muscle strength. Additionally, NHANES data were cross-validated with data from 554 patients at our hospital to evaluate the ability of the systemic immune inflammatory index (SII) to distinguish between low muscle mass and strength.ResultsAfter controlling for all potential confounding factors, multiple logistic regression analysis revealed that apart from the platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and derived NLR (dNLR), the neutrophil-to-monocyte-plus-lymphocyte ratio (NMLR), neutrophil-to-lymphocyte ratio (NLR), SII, systemic inflammation response index (SIRI), and pan-immune-inflammation value (PIV) were significantly negatively correlated with muscle mass and strength. However, NMLR and NLR were significantly associated with changes in muscle mass only in Q4 (P < 0.05). In the stratified analysis by body mass index (BMI), only the SII, NLR, and NMLR were unaffected by BMI. In the cross-validation, the predictive performance of the SII for low muscle mass [area under the curve (AUC) = 0.699, 0.677, and 0.685] and low muscle strength (AUC = 0.857, 0.849, and 0.840) demonstrated a good reference value. RCS and smooth curve fitting analyses indicated that most inflammatory markers were linearly correlated with muscle health (P < 0.05).ConclusionCompared with other inflammatory markers (e.g., PIV and dNLR), the SII demonstrated a more robust predictive ability, was less influence by covariates, and exhibited high generalization performance in internal and external validation. SII may be crucial in identifying “hidden sarcopenia” and the early stages of muscle functional decline. |
| format | Article |
| id | doaj-art-33d414a31ca54bb1a5aaa1112bb05860 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-33d414a31ca54bb1a5aaa1112bb058602025-02-03T05:11:55ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-02-011210.3389/fnut.2025.14987571498757The association between eight complete blood count-derived inflammatory markers and muscle healthJingyuan Zhang0Yuqi Wang1Heng Liu2Zhuolin Lei3Shouquan Cheng4Hong Cao5Department of Traumatic Orthopedics, Renmin Hospital, Hubei University of Medicine, Shiyan, ChinaDepartment of Traumatic Orthopedics, Weifang Yidu Central Hospital, Shiyan, ChinaDepartment of Urology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaDepartment of Traumatic Orthopedics, Renmin Hospital, Hubei University of Medicine, Shiyan, ChinaDepartment of Traumatic Orthopedics, Renmin Hospital, Hubei University of Medicine, Shiyan, ChinaDepartment of Traumatic Orthopedics, Renmin Hospital, Hubei University of Medicine, Shiyan, ChinaBackgroundMost studies have evaluated sarcopenia and muscle health solely based on muscle mass. This study comprehensively examined the associations between eight inflammatory indicators and muscle mass and strength, with the aim of identifying an indicator capable of evaluating muscle health across multiple dimensions.MethodsThis study included 10,440 participants from the National Health and Nutrition Examination Survey (NHANES, 2011–2018) and 5,384 participants from NHANES (2011–2014). Multivariate logistic regression, smooth curve fitting, restricted cubic spline (RCS) analysis, subgroup analysis, and Spearman's correlation were used to comprehensively assess the associations between the eight inflammatory indicators and muscle mass and strength. Receiver operating characteristic (ROC) curves were used to compare the predictive abilities of the different indices for low muscle mass and muscle strength. Additionally, NHANES data were cross-validated with data from 554 patients at our hospital to evaluate the ability of the systemic immune inflammatory index (SII) to distinguish between low muscle mass and strength.ResultsAfter controlling for all potential confounding factors, multiple logistic regression analysis revealed that apart from the platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and derived NLR (dNLR), the neutrophil-to-monocyte-plus-lymphocyte ratio (NMLR), neutrophil-to-lymphocyte ratio (NLR), SII, systemic inflammation response index (SIRI), and pan-immune-inflammation value (PIV) were significantly negatively correlated with muscle mass and strength. However, NMLR and NLR were significantly associated with changes in muscle mass only in Q4 (P < 0.05). In the stratified analysis by body mass index (BMI), only the SII, NLR, and NMLR were unaffected by BMI. In the cross-validation, the predictive performance of the SII for low muscle mass [area under the curve (AUC) = 0.699, 0.677, and 0.685] and low muscle strength (AUC = 0.857, 0.849, and 0.840) demonstrated a good reference value. RCS and smooth curve fitting analyses indicated that most inflammatory markers were linearly correlated with muscle health (P < 0.05).ConclusionCompared with other inflammatory markers (e.g., PIV and dNLR), the SII demonstrated a more robust predictive ability, was less influence by covariates, and exhibited high generalization performance in internal and external validation. SII may be crucial in identifying “hidden sarcopenia” and the early stages of muscle functional decline.https://www.frontiersin.org/articles/10.3389/fnut.2025.1498757/fullsarcopeniamuscle massinflammationindicatorsNHANES |
| spellingShingle | Jingyuan Zhang Yuqi Wang Heng Liu Zhuolin Lei Shouquan Cheng Hong Cao The association between eight complete blood count-derived inflammatory markers and muscle health Frontiers in Nutrition sarcopenia muscle mass inflammation indicators NHANES |
| title | The association between eight complete blood count-derived inflammatory markers and muscle health |
| title_full | The association between eight complete blood count-derived inflammatory markers and muscle health |
| title_fullStr | The association between eight complete blood count-derived inflammatory markers and muscle health |
| title_full_unstemmed | The association between eight complete blood count-derived inflammatory markers and muscle health |
| title_short | The association between eight complete blood count-derived inflammatory markers and muscle health |
| title_sort | association between eight complete blood count derived inflammatory markers and muscle health |
| topic | sarcopenia muscle mass inflammation indicators NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1498757/full |
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