Clinical, microbiologic, and treatment outcomes of dematiaceous fungal keratitis – A retrospective study
Purpose: Dematiaceous fungi, the third most common causative organism of fungal keratitis, constitute 3.5% to 43.5% of fungal keratitis worldwide. Several studies on filamentous fungi (Aspergillus and Fusarium) are available as opposed to that on dematiaceous fungal keratitis. This study aims to des...
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| Format: | Article |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Indian Journal of Ophthalmology |
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| Online Access: | https://journals.lww.com/10.4103/IJO.IJO_1881_23 |
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| author | Niruban Ganesan Shivananda Narayana Joseph Gubert Namrata K Bhosale Balagiri Sundar |
| author_facet | Niruban Ganesan Shivananda Narayana Joseph Gubert Namrata K Bhosale Balagiri Sundar |
| author_sort | Niruban Ganesan |
| collection | DOAJ |
| description | Purpose:
Dematiaceous fungi, the third most common causative organism of fungal keratitis, constitute 3.5% to 43.5% of fungal keratitis worldwide. Several studies on filamentous fungi (Aspergillus and Fusarium) are available as opposed to that on dematiaceous fungal keratitis. This study aims to describe the profile of dematiaceous fungal keratitis in South India.
Methods:
This institutional cohort study on culture-proven dematiaceous fungal keratitis was performed in a single ophthalmology referral center in South India for a 6-year period. Records were analyzed for demographic, clinical, microbiological, and treatment outcomes for 3 months from the date of presentation.
Results:
This study comprised 312 cases involving dematiaceous fungal keratitis (DFK). During the study period, DFK accounted for 10% of microbial keratitis and 24.6% of fungal keratitis cases. The mean (standard deviation) age was 54 (14) years. Males were commonly affected (73.4%). Keratitis was ≤1/3rd depth in 47.8% of cases. Fifty-four cases (17.3%) demonstrated surface pigmentation, and 69 cases (22.1%) had endothelial plaque. Curvularia spp. (99 eyes, 31.7%) was the most common fungal isolate among the speciated fungi. Topical medications resulted in the healing of 63.5% of cases. A total of 193 cases (79%) healed, and 49 cases had to undergo therapeutic penetrating keratoplasty (TPK). Early TPK was performed for 20 cases (40.8%). Seventeen eyes (34.6%) maintained clear grafts at the end of 3 months.
Conclusion:
In this extensive study on DFK, we report a high incidence of this group of fungal keratitis. We found an excellent healing rate in our cohort of patients. |
| format | Article |
| id | doaj-art-33d12871a31e4e10ba842139b8b1fa32 |
| institution | OA Journals |
| issn | 0301-4738 1998-3689 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj-art-33d12871a31e4e10ba842139b8b1fa322025-08-20T01:59:17ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892024-12-0172121721172710.4103/IJO.IJO_1881_23Clinical, microbiologic, and treatment outcomes of dematiaceous fungal keratitis – A retrospective studyNiruban GanesanShivananda NarayanaJoseph GubertNamrata K BhosaleBalagiri SundarPurpose: Dematiaceous fungi, the third most common causative organism of fungal keratitis, constitute 3.5% to 43.5% of fungal keratitis worldwide. Several studies on filamentous fungi (Aspergillus and Fusarium) are available as opposed to that on dematiaceous fungal keratitis. This study aims to describe the profile of dematiaceous fungal keratitis in South India. Methods: This institutional cohort study on culture-proven dematiaceous fungal keratitis was performed in a single ophthalmology referral center in South India for a 6-year period. Records were analyzed for demographic, clinical, microbiological, and treatment outcomes for 3 months from the date of presentation. Results: This study comprised 312 cases involving dematiaceous fungal keratitis (DFK). During the study period, DFK accounted for 10% of microbial keratitis and 24.6% of fungal keratitis cases. The mean (standard deviation) age was 54 (14) years. Males were commonly affected (73.4%). Keratitis was ≤1/3rd depth in 47.8% of cases. Fifty-four cases (17.3%) demonstrated surface pigmentation, and 69 cases (22.1%) had endothelial plaque. Curvularia spp. (99 eyes, 31.7%) was the most common fungal isolate among the speciated fungi. Topical medications resulted in the healing of 63.5% of cases. A total of 193 cases (79%) healed, and 49 cases had to undergo therapeutic penetrating keratoplasty (TPK). Early TPK was performed for 20 cases (40.8%). Seventeen eyes (34.6%) maintained clear grafts at the end of 3 months. Conclusion: In this extensive study on DFK, we report a high incidence of this group of fungal keratitis. We found an excellent healing rate in our cohort of patients.https://journals.lww.com/10.4103/IJO.IJO_1881_23dematiaceous fungal keratitisdemographyincidencemicrobiologypigments |
| spellingShingle | Niruban Ganesan Shivananda Narayana Joseph Gubert Namrata K Bhosale Balagiri Sundar Clinical, microbiologic, and treatment outcomes of dematiaceous fungal keratitis – A retrospective study Indian Journal of Ophthalmology dematiaceous fungal keratitis demography incidence microbiology pigments |
| title | Clinical, microbiologic, and treatment outcomes of dematiaceous fungal keratitis – A retrospective study |
| title_full | Clinical, microbiologic, and treatment outcomes of dematiaceous fungal keratitis – A retrospective study |
| title_fullStr | Clinical, microbiologic, and treatment outcomes of dematiaceous fungal keratitis – A retrospective study |
| title_full_unstemmed | Clinical, microbiologic, and treatment outcomes of dematiaceous fungal keratitis – A retrospective study |
| title_short | Clinical, microbiologic, and treatment outcomes of dematiaceous fungal keratitis – A retrospective study |
| title_sort | clinical microbiologic and treatment outcomes of dematiaceous fungal keratitis a retrospective study |
| topic | dematiaceous fungal keratitis demography incidence microbiology pigments |
| url | https://journals.lww.com/10.4103/IJO.IJO_1881_23 |
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