Diagnostic uncertainty in primary aldosteronism
Aldosterone is a mineralocorticoid hormone originating from the glomerulosa zone of the adrenal cortex. Its main mechanism of action involves the reabsorption of sodium along with the secretion of potassium and hydrogen ions. It is the final hormonal signal in the renin-angiotensin-aldosterone syste...
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Specijalna bolnica za bolesti štitaste žlezde i bolesti metabolizma Zlatibor
2024-01-01
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| Series: | Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor" |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1821-1925/2024/1821-19252495023M.pdf |
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| author | Marković Bojan Stojković Mirjana Janić Tamara Babić Jovana Đurković Ivana Joksimović Nata Nedeljković-Beleslin Biljana Ćirić Jasmina Žarković Miloš |
| author_facet | Marković Bojan Stojković Mirjana Janić Tamara Babić Jovana Đurković Ivana Joksimović Nata Nedeljković-Beleslin Biljana Ćirić Jasmina Žarković Miloš |
| author_sort | Marković Bojan |
| collection | DOAJ |
| description | Aldosterone is a mineralocorticoid hormone originating from the glomerulosa zone of the adrenal cortex. Its main mechanism of action involves the reabsorption of sodium along with the secretion of potassium and hydrogen ions. It is the final hormonal signal in the renin-angiotensin-aldosterone system, which participates in the regulation of circulating volume and systemic vascular resistance. Hypokalemia and hypertension are key indicators for diagnosing hyperaldosteronism. We present the case of a patient who was diagnosed with hypertension at the age of 30. Hypokalemia was first recorded in his 59th year (2023) with a level of 3.1 mmol/L. The analyzed RAAS markers showed an elevated ALDO/ PRA ratio. Computed tomography revealed a change in the right adrenal gland, measuring 9 mm. Given that the baseline aldosterone values were within the normal range for the healthy population, with a suppressed renin activity peak in one sample, primary aldosteronism was suspected. Consequently, confirmatory suppression tests were required to establish the diagnosis. |
| format | Article |
| id | doaj-art-33d113dece4148fa84bd08d081b45aa0 |
| institution | Kabale University |
| issn | 1821-1925 2406-131X |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Specijalna bolnica za bolesti štitaste žlezde i bolesti metabolizma Zlatibor |
| record_format | Article |
| series | Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor" |
| spelling | doaj-art-33d113dece4148fa84bd08d081b45aa02025-01-08T16:29:19ZengSpecijalna bolnica za bolesti štitaste žlezde i bolesti metabolizma ZlatiborMedicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor"1821-19252406-131X2024-01-012995233810.5937/mgiszm2495023M1821-19252495023MDiagnostic uncertainty in primary aldosteronismMarković Bojan0Stojković Mirjana1https://orcid.org/0000-0003-0390-3726Janić Tamara2Babić Jovana3Đurković Ivana4Joksimović Nata5Nedeljković-Beleslin Biljana6https://orcid.org/0000-0002-1687-9297Ćirić Jasmina7Žarković Miloš8https://orcid.org/0000-0001-9977-5970Univerzitetski klinički centar Srbije, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Odeljenje za bolesti štitaste žlezde, Beograd, SerbiaUniverzitetski klinički centar Srbije, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Odeljenje za bolesti štitaste žlezde, Beograd, SerbiaUniverzitetski klinički centar Srbije, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Odeljenje za bolesti štitaste žlezde, Beograd, SerbiaUniverzitetski klinički centar Srbije, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Odeljenje za bolesti štitaste žlezde, Beograd, SerbiaUniverzitetski klinički centar Srbije, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Odeljenje za bolesti štitaste žlezde, Beograd, SerbiaUniverzitetski klinički centar Srbije, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Odeljenje za bolesti štitaste žlezde, Beograd, SerbiaUniverzitetski klinički centar Srbije, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Odeljenje za bolesti štitaste žlezde, Beograd, SerbiaUniverzitetski klinički centar Srbije, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Odeljenje za bolesti štitaste žlezde, Beograd, SerbiaUniverzitetski klinički centar Srbije, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Odeljenje za bolesti štitaste žlezde, Beograd, SerbiaAldosterone is a mineralocorticoid hormone originating from the glomerulosa zone of the adrenal cortex. Its main mechanism of action involves the reabsorption of sodium along with the secretion of potassium and hydrogen ions. It is the final hormonal signal in the renin-angiotensin-aldosterone system, which participates in the regulation of circulating volume and systemic vascular resistance. Hypokalemia and hypertension are key indicators for diagnosing hyperaldosteronism. We present the case of a patient who was diagnosed with hypertension at the age of 30. Hypokalemia was first recorded in his 59th year (2023) with a level of 3.1 mmol/L. The analyzed RAAS markers showed an elevated ALDO/ PRA ratio. Computed tomography revealed a change in the right adrenal gland, measuring 9 mm. Given that the baseline aldosterone values were within the normal range for the healthy population, with a suppressed renin activity peak in one sample, primary aldosteronism was suspected. Consequently, confirmatory suppression tests were required to establish the diagnosis.https://scindeks-clanci.ceon.rs/data/pdf/1821-1925/2024/1821-19252495023M.pdfsecondary hypertensionaldosteronismhypokalemia |
| spellingShingle | Marković Bojan Stojković Mirjana Janić Tamara Babić Jovana Đurković Ivana Joksimović Nata Nedeljković-Beleslin Biljana Ćirić Jasmina Žarković Miloš Diagnostic uncertainty in primary aldosteronism Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor" secondary hypertension aldosteronism hypokalemia |
| title | Diagnostic uncertainty in primary aldosteronism |
| title_full | Diagnostic uncertainty in primary aldosteronism |
| title_fullStr | Diagnostic uncertainty in primary aldosteronism |
| title_full_unstemmed | Diagnostic uncertainty in primary aldosteronism |
| title_short | Diagnostic uncertainty in primary aldosteronism |
| title_sort | diagnostic uncertainty in primary aldosteronism |
| topic | secondary hypertension aldosteronism hypokalemia |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1821-1925/2024/1821-19252495023M.pdf |
| work_keys_str_mv | AT markovicbojan diagnosticuncertaintyinprimaryaldosteronism AT stojkovicmirjana diagnosticuncertaintyinprimaryaldosteronism AT janictamara diagnosticuncertaintyinprimaryaldosteronism AT babicjovana diagnosticuncertaintyinprimaryaldosteronism AT đurkovicivana diagnosticuncertaintyinprimaryaldosteronism AT joksimovicnata diagnosticuncertaintyinprimaryaldosteronism AT nedeljkovicbeleslinbiljana diagnosticuncertaintyinprimaryaldosteronism AT ciricjasmina diagnosticuncertaintyinprimaryaldosteronism AT zarkovicmilos diagnosticuncertaintyinprimaryaldosteronism |