Insights into the transmission cycle of cutaneous leishmaniasis from an endemic community in rural Guatemala
Cutaneous leishmaniasis (CL) is a parasitic vector-borne disease prevalent in 90 countries. Despite its endemicity in Guatemala, key transmission factors are still unknown. To address this, we characterized sand fly populations and Leishmania parasites in a Guatemalan community in 2022. We visited t...
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| Format: | Article |
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Elsevier
2025-01-01
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| Series: | Current Research in Parasitology and Vector-Borne Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667114X25000044 |
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| author | Yaimie Lopez Aitor Casas-Sanchez Byron Arana Nidia Rizzo Erick Duran Norma Padilla Andrea de la Vega Esteban Bustamante Álvaro Acosta-Serrano Renata Mendizabal-Cabrera |
| author_facet | Yaimie Lopez Aitor Casas-Sanchez Byron Arana Nidia Rizzo Erick Duran Norma Padilla Andrea de la Vega Esteban Bustamante Álvaro Acosta-Serrano Renata Mendizabal-Cabrera |
| author_sort | Yaimie Lopez |
| collection | DOAJ |
| description | Cutaneous leishmaniasis (CL) is a parasitic vector-borne disease prevalent in 90 countries. Despite its endemicity in Guatemala, key transmission factors are still unknown. To address this, we characterized sand fly populations and Leishmania parasites in a Guatemalan community in 2022. We visited the households of 23 patients with lesions compatible with CL, sampled for sand flies and analysed Leishmania spp. presence in patients’ skin scrapings and in collected sand flies. We collected 93 sand flies, predominantly females including the vector species Nyssomyia ylephiletor, Bichromomyia olmeca and Lutzomyia cruciata. Nyssomyia ylephiletor was the most abundant species indoors. Four Leishmania spp. were identified including L. panamensis, L. guyanensis, L. braziliensis and L. infantum in CL lesions, L. guyanensis complex species (L. guyanensis or L. panamensis) and Leishmania sp. in sand flies. Sand fly species positive for Leishmania spp. were Ny. ylephiletor, Dampfomyia deleoni, Dampfomyia sp. and Brumptomyia sp. Blood-meal analysis revealed human and pig blood in engorged Ny. ylephiletor collected inside and in the proximity of the households. This is the first report of L. guyanensis in Guatemalan patients and provides insights into CL transmission dynamics, suggesting potential indoor transmission, pending more studies. |
| format | Article |
| id | doaj-art-33ce2fd2026146f382822c2a0ebc82f6 |
| institution | Kabale University |
| issn | 2667-114X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Parasitology and Vector-Borne Diseases |
| spelling | doaj-art-33ce2fd2026146f382822c2a0ebc82f62025-02-08T05:01:35ZengElsevierCurrent Research in Parasitology and Vector-Borne Diseases2667-114X2025-01-017100244Insights into the transmission cycle of cutaneous leishmaniasis from an endemic community in rural GuatemalaYaimie Lopez0Aitor Casas-Sanchez1Byron Arana2Nidia Rizzo3Erick Duran4Norma Padilla5Andrea de la Vega6Esteban Bustamante7Álvaro Acosta-Serrano8Renata Mendizabal-Cabrera9Centre for Health Studies, Universidad Del Valle de Guatemala, Guatemala City, Guatemala; Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK; Corresponding author. Centre for Health Studies, Universidad del Valle de Guatemala, Guatemala City, Guatemala.Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UKCentre for Health Studies, Universidad Del Valle de Guatemala, Guatemala City, GuatemalaCentre for Health Studies, Universidad Del Valle de Guatemala, Guatemala City, GuatemalaMinistry of Health and Social Welfare, Guatemala City, GuatemalaCentre for Health Studies, Universidad Del Valle de Guatemala, Guatemala City, GuatemalaDepartment of Biochemistry, Universidad Del Valle de Guatemala City, GuatemalaDepartment of Biochemistry, Universidad Del Valle de Guatemala City, GuatemalaDepartment of Biological Sciences, University of Notre Dame, Indiana, USACentre for Health Studies, Universidad Del Valle de Guatemala, Guatemala City, GuatemalaCutaneous leishmaniasis (CL) is a parasitic vector-borne disease prevalent in 90 countries. Despite its endemicity in Guatemala, key transmission factors are still unknown. To address this, we characterized sand fly populations and Leishmania parasites in a Guatemalan community in 2022. We visited the households of 23 patients with lesions compatible with CL, sampled for sand flies and analysed Leishmania spp. presence in patients’ skin scrapings and in collected sand flies. We collected 93 sand flies, predominantly females including the vector species Nyssomyia ylephiletor, Bichromomyia olmeca and Lutzomyia cruciata. Nyssomyia ylephiletor was the most abundant species indoors. Four Leishmania spp. were identified including L. panamensis, L. guyanensis, L. braziliensis and L. infantum in CL lesions, L. guyanensis complex species (L. guyanensis or L. panamensis) and Leishmania sp. in sand flies. Sand fly species positive for Leishmania spp. were Ny. ylephiletor, Dampfomyia deleoni, Dampfomyia sp. and Brumptomyia sp. Blood-meal analysis revealed human and pig blood in engorged Ny. ylephiletor collected inside and in the proximity of the households. This is the first report of L. guyanensis in Guatemalan patients and provides insights into CL transmission dynamics, suggesting potential indoor transmission, pending more studies.http://www.sciencedirect.com/science/article/pii/S2667114X25000044Sand flyTransmissionCutaneous leishmaniasisEpidemiologyGuatemala |
| spellingShingle | Yaimie Lopez Aitor Casas-Sanchez Byron Arana Nidia Rizzo Erick Duran Norma Padilla Andrea de la Vega Esteban Bustamante Álvaro Acosta-Serrano Renata Mendizabal-Cabrera Insights into the transmission cycle of cutaneous leishmaniasis from an endemic community in rural Guatemala Current Research in Parasitology and Vector-Borne Diseases Sand fly Transmission Cutaneous leishmaniasis Epidemiology Guatemala |
| title | Insights into the transmission cycle of cutaneous leishmaniasis from an endemic community in rural Guatemala |
| title_full | Insights into the transmission cycle of cutaneous leishmaniasis from an endemic community in rural Guatemala |
| title_fullStr | Insights into the transmission cycle of cutaneous leishmaniasis from an endemic community in rural Guatemala |
| title_full_unstemmed | Insights into the transmission cycle of cutaneous leishmaniasis from an endemic community in rural Guatemala |
| title_short | Insights into the transmission cycle of cutaneous leishmaniasis from an endemic community in rural Guatemala |
| title_sort | insights into the transmission cycle of cutaneous leishmaniasis from an endemic community in rural guatemala |
| topic | Sand fly Transmission Cutaneous leishmaniasis Epidemiology Guatemala |
| url | http://www.sciencedirect.com/science/article/pii/S2667114X25000044 |
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