Targeting autophagy to enhance chemotherapy and immunotherapy in oral cancer
Oral cancer is a highly malignant disease characterized by recurrence, metastasis, and poor prognosis. Autophagy, a catabolic process induced under stress conditions, has been shown to play a dual role in oral cancer development and therapy. Recent studies have identified that autophagy activation i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1535649/full |
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| author | Xiaoli Zeng Xiaoli Zeng Xiaoli Zeng Yue Chen Yue Chen Jing Wang Jing Wang Miao He Miao He Junyao Qiu Yun Huang |
| author_facet | Xiaoli Zeng Xiaoli Zeng Xiaoli Zeng Yue Chen Yue Chen Jing Wang Jing Wang Miao He Miao He Junyao Qiu Yun Huang |
| author_sort | Xiaoli Zeng |
| collection | DOAJ |
| description | Oral cancer is a highly malignant disease characterized by recurrence, metastasis, and poor prognosis. Autophagy, a catabolic process induced under stress conditions, has been shown to play a dual role in oral cancer development and therapy. Recent studies have identified that autophagy activation in oral epithelial cells suppresses cancer cell survival by inhibiting key pathways such as the mammalian target of rapamycin (mTOR) and mitogen-activated protein kinase (MAPK), while activating the adenosine monophosphate-activated protein kinase (AMPK) pathway. Inducing autophagy promotes degradation of eukaryotic initiation factor 4E, thus reducing metastasis and enhancing the efficacy of chemotherapy, radiotherapy, and immunotherapy. Furthermore, autophagy induction can modulate the tumor immune microenvironment and enhance antitumor immunity. This review comprehensively summarizes the relationship between autophagy and oral cancer, focusing on its mechanisms and therapeutic potential when combined with conventional treatments. While promising, the precise mechanisms and clinical applications of autophagy inducers in oral cancer therapy remain to be elucidated, offering new directions for future research to improve treatment outcomes and reduce recurrence. |
| format | Article |
| id | doaj-art-33ca9a8a20454f0588626cd645145a7b |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-33ca9a8a20454f0588626cd645145a7b2025-01-07T06:48:16ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15356491535649Targeting autophagy to enhance chemotherapy and immunotherapy in oral cancerXiaoli Zeng0Xiaoli Zeng1Xiaoli Zeng2Yue Chen3Yue Chen4Jing Wang5Jing Wang6Miao He7Miao He8Junyao Qiu9Yun Huang10Department of Oncology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaJiangxi "Flagship" Oncology Department of Synergy for Chinese and Western Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Oncology, Jiangxi Clinical Medical Research Center for Cancer, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Oncology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Oncology, Jiangxi Clinical Medical Research Center for Cancer, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Oncology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Oncology, Jiangxi Clinical Medical Research Center for Cancer, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Oncology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Oncology, Jiangxi Clinical Medical Research Center for Cancer, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Gastroenterology, The Affiliated Ganzhou Hospital of Nanchang University, Ganzhou, Jiangxi, ChinaDepartment of Otolaryngology, The Affiliated Ganzhou Hospital of Nanchang University, Ganzhou, Jiangxi, ChinaOral cancer is a highly malignant disease characterized by recurrence, metastasis, and poor prognosis. Autophagy, a catabolic process induced under stress conditions, has been shown to play a dual role in oral cancer development and therapy. Recent studies have identified that autophagy activation in oral epithelial cells suppresses cancer cell survival by inhibiting key pathways such as the mammalian target of rapamycin (mTOR) and mitogen-activated protein kinase (MAPK), while activating the adenosine monophosphate-activated protein kinase (AMPK) pathway. Inducing autophagy promotes degradation of eukaryotic initiation factor 4E, thus reducing metastasis and enhancing the efficacy of chemotherapy, radiotherapy, and immunotherapy. Furthermore, autophagy induction can modulate the tumor immune microenvironment and enhance antitumor immunity. This review comprehensively summarizes the relationship between autophagy and oral cancer, focusing on its mechanisms and therapeutic potential when combined with conventional treatments. While promising, the precise mechanisms and clinical applications of autophagy inducers in oral cancer therapy remain to be elucidated, offering new directions for future research to improve treatment outcomes and reduce recurrence.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1535649/fullautophagyoral cancerapoptosischemotherapyradiotherapyimmunotherapy |
| spellingShingle | Xiaoli Zeng Xiaoli Zeng Xiaoli Zeng Yue Chen Yue Chen Jing Wang Jing Wang Miao He Miao He Junyao Qiu Yun Huang Targeting autophagy to enhance chemotherapy and immunotherapy in oral cancer Frontiers in Immunology autophagy oral cancer apoptosis chemotherapy radiotherapy immunotherapy |
| title | Targeting autophagy to enhance chemotherapy and immunotherapy in oral cancer |
| title_full | Targeting autophagy to enhance chemotherapy and immunotherapy in oral cancer |
| title_fullStr | Targeting autophagy to enhance chemotherapy and immunotherapy in oral cancer |
| title_full_unstemmed | Targeting autophagy to enhance chemotherapy and immunotherapy in oral cancer |
| title_short | Targeting autophagy to enhance chemotherapy and immunotherapy in oral cancer |
| title_sort | targeting autophagy to enhance chemotherapy and immunotherapy in oral cancer |
| topic | autophagy oral cancer apoptosis chemotherapy radiotherapy immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1535649/full |
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