Morbidity and Mortality Predictors of Acute Respiratory Failure in Acute Pancreatitis: A Cohort Study Conducted in Vietnam
ABSTRACT Background and Aim Acute pancreatitis (AP) can result in severe complications, with acute respiratory failure (ARF) being among the most critical. Research on ARF in AP remains limited. This study aims to investigate the occurrence, outcomes, and predictors of ARF in AP patients at Cho Ray...
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Wiley
2025-03-01
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| Online Access: | https://doi.org/10.1002/jgh3.70136 |
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| author | Qui Huu Nguyen Dung Thi My Vo Thong Duy Vo |
| author_facet | Qui Huu Nguyen Dung Thi My Vo Thong Duy Vo |
| author_sort | Qui Huu Nguyen |
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| description | ABSTRACT Background and Aim Acute pancreatitis (AP) can result in severe complications, with acute respiratory failure (ARF) being among the most critical. Research on ARF in AP remains limited. This study aims to investigate the occurrence, outcomes, and predictors of ARF in AP patients at Cho Ray Hospital, a tertiary care center in Vietnam. Method A prospective cohort study was conducted with 230 AP patients at a national hospital in Ho Chi Minh City, Vietnam. Patients were divided into ARF and non‐ARF groups, and clinical characteristics were compared. Key outcomes included invasive mechanical ventilation, in‐hospital mortality, and length of hospital stay. Results ARF developed in 26.1% of patients, with a mortality rate of 25.0% in the ARF group versus 1.2% in the non‐ARF group. Mechanical ventilation was required in 48.3% of ARF patients. Significant predictors of ARF were abnormal body mass index (BMI) (p = 0.021), prolonged systemic inflammatory response syndrome (SIRS) (p < 0.001), modified computed tomography severity index (mCTSI) (p = 0.041), and a high bedside index for severity in acute pancreatitis (BISAP) score (p < 0.001). BISAP scores ≥ 2 had a sensitivity of 90.0%, specificity of 73.5%, and AUC of 0.878 (95% CI 0.829–0.921) for predicting ARF. Predictors of mortality in ARF patients included cardiovascular failure (HR 15.83, p = 0.001), prolonged SIRS (HR 4.76, p = 0.038), and high BISAP scores (HR 3.41, p = 0.015). Conclusion ARF significantly worsens outcomes in AP patients. Early identification of key predictors, like abnormal BMI, prolonged SIRS, mCTSI, and BISAP scores, could improve interventions and patient prognosis. |
| format | Article |
| id | doaj-art-33c3dc034d334223b9b90e8b632f01c2 |
| institution | OA Journals |
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| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
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| series | JGH Open |
| spelling | doaj-art-33c3dc034d334223b9b90e8b632f01c22025-08-20T02:10:34ZengWileyJGH Open2397-90702025-03-0193n/an/a10.1002/jgh3.70136Morbidity and Mortality Predictors of Acute Respiratory Failure in Acute Pancreatitis: A Cohort Study Conducted in VietnamQui Huu Nguyen0Dung Thi My Vo1Thong Duy Vo2Department of Internal Medicine, Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh city VietnamDepartment of Internal Medicine, Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh city VietnamDepartment of Internal Medicine, Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh city VietnamABSTRACT Background and Aim Acute pancreatitis (AP) can result in severe complications, with acute respiratory failure (ARF) being among the most critical. Research on ARF in AP remains limited. This study aims to investigate the occurrence, outcomes, and predictors of ARF in AP patients at Cho Ray Hospital, a tertiary care center in Vietnam. Method A prospective cohort study was conducted with 230 AP patients at a national hospital in Ho Chi Minh City, Vietnam. Patients were divided into ARF and non‐ARF groups, and clinical characteristics were compared. Key outcomes included invasive mechanical ventilation, in‐hospital mortality, and length of hospital stay. Results ARF developed in 26.1% of patients, with a mortality rate of 25.0% in the ARF group versus 1.2% in the non‐ARF group. Mechanical ventilation was required in 48.3% of ARF patients. Significant predictors of ARF were abnormal body mass index (BMI) (p = 0.021), prolonged systemic inflammatory response syndrome (SIRS) (p < 0.001), modified computed tomography severity index (mCTSI) (p = 0.041), and a high bedside index for severity in acute pancreatitis (BISAP) score (p < 0.001). BISAP scores ≥ 2 had a sensitivity of 90.0%, specificity of 73.5%, and AUC of 0.878 (95% CI 0.829–0.921) for predicting ARF. Predictors of mortality in ARF patients included cardiovascular failure (HR 15.83, p = 0.001), prolonged SIRS (HR 4.76, p = 0.038), and high BISAP scores (HR 3.41, p = 0.015). Conclusion ARF significantly worsens outcomes in AP patients. Early identification of key predictors, like abnormal BMI, prolonged SIRS, mCTSI, and BISAP scores, could improve interventions and patient prognosis.https://doi.org/10.1002/jgh3.70136acute pancreatitisacute respiratory failureBISAPSIRS |
| spellingShingle | Qui Huu Nguyen Dung Thi My Vo Thong Duy Vo Morbidity and Mortality Predictors of Acute Respiratory Failure in Acute Pancreatitis: A Cohort Study Conducted in Vietnam JGH Open acute pancreatitis acute respiratory failure BISAP SIRS |
| title | Morbidity and Mortality Predictors of Acute Respiratory Failure in Acute Pancreatitis: A Cohort Study Conducted in Vietnam |
| title_full | Morbidity and Mortality Predictors of Acute Respiratory Failure in Acute Pancreatitis: A Cohort Study Conducted in Vietnam |
| title_fullStr | Morbidity and Mortality Predictors of Acute Respiratory Failure in Acute Pancreatitis: A Cohort Study Conducted in Vietnam |
| title_full_unstemmed | Morbidity and Mortality Predictors of Acute Respiratory Failure in Acute Pancreatitis: A Cohort Study Conducted in Vietnam |
| title_short | Morbidity and Mortality Predictors of Acute Respiratory Failure in Acute Pancreatitis: A Cohort Study Conducted in Vietnam |
| title_sort | morbidity and mortality predictors of acute respiratory failure in acute pancreatitis a cohort study conducted in vietnam |
| topic | acute pancreatitis acute respiratory failure BISAP SIRS |
| url | https://doi.org/10.1002/jgh3.70136 |
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