Long-term administration of alendronate sodium caused an atypical femoral shaft fracture in a 36-year-old woman: a case report and literature review

Long-term bisphosphonate therapy is associated with atypical or insufficiency fractures, particularly in the proximal femur. We observed a case of an atypical femoral shaft fracture in a patient with a long-term history of alendronate therapy. A 36-year-old woman was admitted with a complaint of pai...

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Main Authors: Wenyu Duan, Maochang Qiang, Haidong Zhang, Dongming Zhou
Format: Article
Language:English
Published: SAGE Publishing 2024-10-01
Series:Journal of International Medical Research
Online Access:https://doi.org/10.1177/03000605241286650
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author Wenyu Duan
Maochang Qiang
Haidong Zhang
Dongming Zhou
author_facet Wenyu Duan
Maochang Qiang
Haidong Zhang
Dongming Zhou
author_sort Wenyu Duan
collection DOAJ
description Long-term bisphosphonate therapy is associated with atypical or insufficiency fractures, particularly in the proximal femur. We observed a case of an atypical femoral shaft fracture in a patient with a long-term history of alendronate therapy. A 36-year-old woman was admitted with a complaint of pain in her right mid-thigh following low-energy trauma. She had been taking alendronate for more than 15 years. X-rays indicated a fracture of the right femoral shaft. The patient was treated with proximal femoral nail antirotation (PFNA) fixation. This case highlights concerns regarding long-term bisphosphonate therapy and its potential complications.
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issn 1473-2300
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publisher SAGE Publishing
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series Journal of International Medical Research
spelling doaj-art-33bdb148887e492fae0b39aeb8aeec332025-08-20T01:47:25ZengSAGE PublishingJournal of International Medical Research1473-23002024-10-015210.1177/03000605241286650Long-term administration of alendronate sodium caused an atypical femoral shaft fracture in a 36-year-old woman: a case report and literature reviewWenyu DuanMaochang QiangHaidong ZhangDongming ZhouLong-term bisphosphonate therapy is associated with atypical or insufficiency fractures, particularly in the proximal femur. We observed a case of an atypical femoral shaft fracture in a patient with a long-term history of alendronate therapy. A 36-year-old woman was admitted with a complaint of pain in her right mid-thigh following low-energy trauma. She had been taking alendronate for more than 15 years. X-rays indicated a fracture of the right femoral shaft. The patient was treated with proximal femoral nail antirotation (PFNA) fixation. This case highlights concerns regarding long-term bisphosphonate therapy and its potential complications.https://doi.org/10.1177/03000605241286650
spellingShingle Wenyu Duan
Maochang Qiang
Haidong Zhang
Dongming Zhou
Long-term administration of alendronate sodium caused an atypical femoral shaft fracture in a 36-year-old woman: a case report and literature review
Journal of International Medical Research
title Long-term administration of alendronate sodium caused an atypical femoral shaft fracture in a 36-year-old woman: a case report and literature review
title_full Long-term administration of alendronate sodium caused an atypical femoral shaft fracture in a 36-year-old woman: a case report and literature review
title_fullStr Long-term administration of alendronate sodium caused an atypical femoral shaft fracture in a 36-year-old woman: a case report and literature review
title_full_unstemmed Long-term administration of alendronate sodium caused an atypical femoral shaft fracture in a 36-year-old woman: a case report and literature review
title_short Long-term administration of alendronate sodium caused an atypical femoral shaft fracture in a 36-year-old woman: a case report and literature review
title_sort long term administration of alendronate sodium caused an atypical femoral shaft fracture in a 36 year old woman a case report and literature review
url https://doi.org/10.1177/03000605241286650
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