Constraint-based modeling of bioenergetic differences between synaptic and non-synaptic components of dopaminergic neurons in Parkinson’s disease

Constraint-based modeling of bioenergetic differences between synaptic and non-synaptic components of dopaminergic neurons in Parkinson’s disease

IntroductionEmerging evidence suggests that different metabolic characteristics, particularly bioenergetic differences, between the synaptic terminal and soma may contribute to the selective vulnerability of dopaminergic neurons in patients with Parkinson’s disease (PD).MethodTo investigate the meta...

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Bibliographic Details
Main Authors: Xi Luo, Diana C. El Assal, Yanjun Liu, Samira Ranjbar, Ronan M.T. Fleming
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Computational Neuroscience
Subjects:
Parkinson’s disease
bioenergetics
synaptic
non-synaptic
modeling
Online Access:https://www.frontiersin.org/articles/10.3389/fncom.2025.1594330/full
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