Synthesis and In Vitro Evaluation of New Thiosemicarbazone Derivatives as Potential Antimicrobial Agents
In an effort to develop potent antimicrobial agents, new thiosemicarbazone derivatives were synthesized via the reaction of 4-[4-(trifluoromethyl)phenyl]thiosemicarbazide with aromatic aldehydes. The compounds were evaluated for their inhibitory effects on pathogenic bacteria and yeasts using the CL...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2016/1692540 |
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| author | Zafer Asım Kaplancıklı Mehlika Dilek Altıntop Belgin Sever Zerrin Cantürk Ahmet Özdemir |
| author_facet | Zafer Asım Kaplancıklı Mehlika Dilek Altıntop Belgin Sever Zerrin Cantürk Ahmet Özdemir |
| author_sort | Zafer Asım Kaplancıklı |
| collection | DOAJ |
| description | In an effort to develop potent antimicrobial agents, new thiosemicarbazone derivatives were synthesized via the reaction of 4-[4-(trifluoromethyl)phenyl]thiosemicarbazide with aromatic aldehydes. The compounds were evaluated for their inhibitory effects on pathogenic bacteria and yeasts using the CLSI broth microdilution method. Microplate Alamar Blue Assay was also carried out to determine the antimycobacterial activities of the compounds against Mycobacterium tuberculosis H37Rv. Among these derivatives, compounds 5 and 11 were more effective against Enterococcus faecalis (ATCC 29212) than chloramphenicol, whereas compounds 1, 2, and 12 and chloramphenicol showed the same level of antibacterial activity against E. faecalis. Moreover, compound 2 and chloramphenicol exhibited the same level of antibacterial activity against Staphylococcus aureus. On the other hand, the most potent anticandidal derivatives were found as compounds 2 and 5. These derivatives and ketoconazole exhibited the same level of antifungal activity against Candida glabrata. According to the Microplate Alamar Blue Assay, the tested compounds showed weak to moderate antitubercular activity. |
| format | Article |
| id | doaj-art-33ae25421f0f4d329bce2c33db887094 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-33ae25421f0f4d329bce2c33db8870942025-08-20T03:55:12ZengWileyJournal of Chemistry2090-90632090-90712016-01-01201610.1155/2016/16925401692540Synthesis and In Vitro Evaluation of New Thiosemicarbazone Derivatives as Potential Antimicrobial AgentsZafer Asım Kaplancıklı0Mehlika Dilek Altıntop1Belgin Sever2Zerrin Cantürk3Ahmet Özdemir4Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, TurkeyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, TurkeyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, TurkeyDepartment of Pharmaceutical Microbiology, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, TurkeyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, TurkeyIn an effort to develop potent antimicrobial agents, new thiosemicarbazone derivatives were synthesized via the reaction of 4-[4-(trifluoromethyl)phenyl]thiosemicarbazide with aromatic aldehydes. The compounds were evaluated for their inhibitory effects on pathogenic bacteria and yeasts using the CLSI broth microdilution method. Microplate Alamar Blue Assay was also carried out to determine the antimycobacterial activities of the compounds against Mycobacterium tuberculosis H37Rv. Among these derivatives, compounds 5 and 11 were more effective against Enterococcus faecalis (ATCC 29212) than chloramphenicol, whereas compounds 1, 2, and 12 and chloramphenicol showed the same level of antibacterial activity against E. faecalis. Moreover, compound 2 and chloramphenicol exhibited the same level of antibacterial activity against Staphylococcus aureus. On the other hand, the most potent anticandidal derivatives were found as compounds 2 and 5. These derivatives and ketoconazole exhibited the same level of antifungal activity against Candida glabrata. According to the Microplate Alamar Blue Assay, the tested compounds showed weak to moderate antitubercular activity.http://dx.doi.org/10.1155/2016/1692540 |
| spellingShingle | Zafer Asım Kaplancıklı Mehlika Dilek Altıntop Belgin Sever Zerrin Cantürk Ahmet Özdemir Synthesis and In Vitro Evaluation of New Thiosemicarbazone Derivatives as Potential Antimicrobial Agents Journal of Chemistry |
| title | Synthesis and In Vitro Evaluation of New Thiosemicarbazone Derivatives as Potential Antimicrobial Agents |
| title_full | Synthesis and In Vitro Evaluation of New Thiosemicarbazone Derivatives as Potential Antimicrobial Agents |
| title_fullStr | Synthesis and In Vitro Evaluation of New Thiosemicarbazone Derivatives as Potential Antimicrobial Agents |
| title_full_unstemmed | Synthesis and In Vitro Evaluation of New Thiosemicarbazone Derivatives as Potential Antimicrobial Agents |
| title_short | Synthesis and In Vitro Evaluation of New Thiosemicarbazone Derivatives as Potential Antimicrobial Agents |
| title_sort | synthesis and in vitro evaluation of new thiosemicarbazone derivatives as potential antimicrobial agents |
| url | http://dx.doi.org/10.1155/2016/1692540 |
| work_keys_str_mv | AT zaferasımkaplancıklı synthesisandinvitroevaluationofnewthiosemicarbazonederivativesaspotentialantimicrobialagents AT mehlikadilekaltıntop synthesisandinvitroevaluationofnewthiosemicarbazonederivativesaspotentialantimicrobialagents AT belginsever synthesisandinvitroevaluationofnewthiosemicarbazonederivativesaspotentialantimicrobialagents AT zerrincanturk synthesisandinvitroevaluationofnewthiosemicarbazonederivativesaspotentialantimicrobialagents AT ahmetozdemir synthesisandinvitroevaluationofnewthiosemicarbazonederivativesaspotentialantimicrobialagents |