Adenine, a key player in biology and medicinal chemistry
Adenine is one of the most ubiquitous heterocycles in life. In addition of being one of the four nucleobases constituting DNA and RNA, adenine is also contained in many biological molecules (ATP, SAM, NAD, cAMP, coA ...) that have fundamental roles in the functioning of living systems, e.g. energy s...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Académie des sciences
2024-04-01
|
| Series: | Comptes Rendus. Chimie |
| Subjects: | |
| Online Access: | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.279/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825206065966350336 |
|---|---|
| author | Fillion, Alexandra Vichier-Guerre, Sophie Arimondo, Paola Barbara |
| author_facet | Fillion, Alexandra Vichier-Guerre, Sophie Arimondo, Paola Barbara |
| author_sort | Fillion, Alexandra |
| collection | DOAJ |
| description | Adenine is one of the most ubiquitous heterocycles in life. In addition of being one of the four nucleobases constituting DNA and RNA, adenine is also contained in many biological molecules (ATP, SAM, NAD, cAMP, coA ...) that have fundamental roles in the functioning of living systems, e.g. energy source, cofactors of enzymes and proteins. As such, the adenine has naturally become a privileged scaffold explored in medicinal chemistry for biomedical applications. Many chemical modifications and Structure-Activity Relationships studies have been carried out on the adenine scaffold to result in potent analogues with various biological activities. Today, numerous adenine-based inhibitors are used to treat a wide range of diseases including cancer, viral and bacterial diseases. This review aims to introduce the adenine and discuss adenine-based inhibitors, their design and use for different therapeutic targets through examples of drugs and compounds that reached clinical and preclinical trials. |
| format | Article |
| id | doaj-art-33a669dd07284e719e8d6a1a207dd47d |
| institution | Kabale University |
| issn | 1878-1543 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus. Chimie |
| spelling | doaj-art-33a669dd07284e719e8d6a1a207dd47d2025-02-07T13:40:29ZengAcadémie des sciencesComptes Rendus. Chimie1878-15432024-04-0127S214316010.5802/crchim.27910.5802/crchim.279Adenine, a key player in biology and medicinal chemistryFillion, Alexandra0https://orcid.org/0009-0001-4965-7340Vichier-Guerre, Sophie1Arimondo, Paola Barbara2https://orcid.org/0000-0001-5175-4396Institut Pasteur, Université Paris Cité, CNRS UMR3523 Chem4Life, Epigenetic Chemical Biology, Department of Structural Biology and Chemistry, 75015 Paris, France; Université Paris Cité, Ecole Doctorale MTCI, Paris, FranceInstitut Pasteur, Université Paris Cité, CNRS UMR3523 Chem4Life, Epigenetic Chemical Biology, Department of Structural Biology and Chemistry, 75015 Paris, FranceInstitut Pasteur, Université Paris Cité, CNRS UMR3523 Chem4Life, Epigenetic Chemical Biology, Department of Structural Biology and Chemistry, 75015 Paris, FranceAdenine is one of the most ubiquitous heterocycles in life. In addition of being one of the four nucleobases constituting DNA and RNA, adenine is also contained in many biological molecules (ATP, SAM, NAD, cAMP, coA ...) that have fundamental roles in the functioning of living systems, e.g. energy source, cofactors of enzymes and proteins. As such, the adenine has naturally become a privileged scaffold explored in medicinal chemistry for biomedical applications. Many chemical modifications and Structure-Activity Relationships studies have been carried out on the adenine scaffold to result in potent analogues with various biological activities. Today, numerous adenine-based inhibitors are used to treat a wide range of diseases including cancer, viral and bacterial diseases. This review aims to introduce the adenine and discuss adenine-based inhibitors, their design and use for different therapeutic targets through examples of drugs and compounds that reached clinical and preclinical trials.https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.279/AdenineMedicinal chemistryInhibitorsAnticancerAntiviral and antibactirial agents |
| spellingShingle | Fillion, Alexandra Vichier-Guerre, Sophie Arimondo, Paola Barbara Adenine, a key player in biology and medicinal chemistry Comptes Rendus. Chimie Adenine Medicinal chemistry Inhibitors Anticancer Antiviral and antibactirial agents |
| title | Adenine, a key player in biology and medicinal chemistry |
| title_full | Adenine, a key player in biology and medicinal chemistry |
| title_fullStr | Adenine, a key player in biology and medicinal chemistry |
| title_full_unstemmed | Adenine, a key player in biology and medicinal chemistry |
| title_short | Adenine, a key player in biology and medicinal chemistry |
| title_sort | adenine a key player in biology and medicinal chemistry |
| topic | Adenine Medicinal chemistry Inhibitors Anticancer Antiviral and antibactirial agents |
| url | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.279/ |
| work_keys_str_mv | AT fillionalexandra adenineakeyplayerinbiologyandmedicinalchemistry AT vichierguerresophie adenineakeyplayerinbiologyandmedicinalchemistry AT arimondopaolabarbara adenineakeyplayerinbiologyandmedicinalchemistry |