Slow Late Component in Conditioned Stimulus-Evoked Potentials From the Amygdala After Fear Conditioning in the Rat
Male Wistar rats were subjected to a differential Pavlovian fear conditioning procedure in which one of two tones (6 or 10 kHz) was followed by an electric shock (CS+) and the other was not (CS-). Before and after fear conditioning, we recorded the evoked potentials elicited by CS+ and CS- from elec...
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2002-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/NP.2002.261 |
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| author | J. M. J. Knippenberg E. L. J. M. van Luijtelaar J. H. R. Maes |
| author_facet | J. M. J. Knippenberg E. L. J. M. van Luijtelaar J. H. R. Maes |
| author_sort | J. M. J. Knippenberg |
| collection | DOAJ |
| description | Male Wistar rats were subjected to a
differential Pavlovian fear conditioning procedure
in which one of two tones (6 or 10 kHz)
was followed by an electric shock (CS+) and the
other was not (CS-). Before and after fear
conditioning, we recorded the evoked potentials
elicited by CS+ and CS- from electrodes aimed at
the lateral nucleus of the amygdala. Before
conditioning, a slow, negative component with
peak amplitude around 150 ms was present in
the evoked potentials. This component was
sensitive to habituation. After fear conditioning,
both CS+ and CS- elicited the same late
component, albeit with a larger amplitude. This
enhancement was temporary: decreasing
amplitude was observed in the course of CS test
presentations under extinction. Prior research
revealed a comparable slow component in the
amygdala of the cat under similar experimental
conditions. The collective results indicate that
the large late component in the amygdala is
enhanced by fear conditioning, suggesting that
such enhancement reflects the anticipation of a
biologically significant event. |
| format | Article |
| id | doaj-art-33a267da321f49a293a74a85f2dceffb |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2002-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-33a267da321f49a293a74a85f2dceffb2025-02-03T01:32:41ZengWileyNeural Plasticity2090-59041687-54432002-01-019426127210.1155/NP.2002.261Slow Late Component in Conditioned Stimulus-Evoked Potentials From the Amygdala After Fear Conditioning in the RatJ. M. J. Knippenberg0E. L. J. M. van Luijtelaar1J. H. R. Maes2University of Nijmegen, Department of Biological Psychology, P.O. Box 9104, Nijmegen 6500 HE, The NetherlandsUniversity of Nijmegen, Department of Biological Psychology, P.O. Box 9104, Nijmegen 6500 HE, The NetherlandsUniversity of Nijmegen, Department of Biological Psychology, P.O. Box 9104, Nijmegen 6500 HE, The NetherlandsMale Wistar rats were subjected to a differential Pavlovian fear conditioning procedure in which one of two tones (6 or 10 kHz) was followed by an electric shock (CS+) and the other was not (CS-). Before and after fear conditioning, we recorded the evoked potentials elicited by CS+ and CS- from electrodes aimed at the lateral nucleus of the amygdala. Before conditioning, a slow, negative component with peak amplitude around 150 ms was present in the evoked potentials. This component was sensitive to habituation. After fear conditioning, both CS+ and CS- elicited the same late component, albeit with a larger amplitude. This enhancement was temporary: decreasing amplitude was observed in the course of CS test presentations under extinction. Prior research revealed a comparable slow component in the amygdala of the cat under similar experimental conditions. The collective results indicate that the large late component in the amygdala is enhanced by fear conditioning, suggesting that such enhancement reflects the anticipation of a biologically significant event.http://dx.doi.org/10.1155/NP.2002.261 |
| spellingShingle | J. M. J. Knippenberg E. L. J. M. van Luijtelaar J. H. R. Maes Slow Late Component in Conditioned Stimulus-Evoked Potentials From the Amygdala After Fear Conditioning in the Rat Neural Plasticity |
| title | Slow Late Component in Conditioned Stimulus-Evoked Potentials
From the Amygdala After Fear Conditioning in the Rat |
| title_full | Slow Late Component in Conditioned Stimulus-Evoked Potentials
From the Amygdala After Fear Conditioning in the Rat |
| title_fullStr | Slow Late Component in Conditioned Stimulus-Evoked Potentials
From the Amygdala After Fear Conditioning in the Rat |
| title_full_unstemmed | Slow Late Component in Conditioned Stimulus-Evoked Potentials
From the Amygdala After Fear Conditioning in the Rat |
| title_short | Slow Late Component in Conditioned Stimulus-Evoked Potentials
From the Amygdala After Fear Conditioning in the Rat |
| title_sort | slow late component in conditioned stimulus evoked potentials from the amygdala after fear conditioning in the rat |
| url | http://dx.doi.org/10.1155/NP.2002.261 |
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