The hidden impact of myopia severity on interocular suppression in myopia: a cross-sectional study
ObjectiveThis study aimed to investigate the association between spherical equivalent (SE) and interocular suppression in myopic adults, addressing the knowledge gap in functional visual impairments beyond structural changes.MethodsThis hospital-based cross-sectional study included 988 myopic patien...
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Frontiers Media S.A.
2025-06-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1481541/full |
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| author | Yan Luo Xiyang Yang Enwei Lin Min Kong Wuqiang Luo Qi Chen Jin Zeng Li Yan Lili Li Xin Xiao Xin Xiao Xin Xiao |
| author_facet | Yan Luo Xiyang Yang Enwei Lin Min Kong Wuqiang Luo Qi Chen Jin Zeng Li Yan Lili Li Xin Xiao Xin Xiao Xin Xiao |
| author_sort | Yan Luo |
| collection | DOAJ |
| description | ObjectiveThis study aimed to investigate the association between spherical equivalent (SE) and interocular suppression in myopic adults, addressing the knowledge gap in functional visual impairments beyond structural changes.MethodsThis hospital-based cross-sectional study included 988 myopic patients (aged 18.0–48.7 years, SE ≥ 0.50D). Grating stereopsis (GS), fine stereopsis at 1.5 m (FS1.5), fine stereopsis at 0.8 m (FS0.8), division, fusion, and interocular suppression were examined via computer-based tasks. Multivariate logistic regression analysis and restricted cubic splines (RCSs) were used to analyze the dose–response relationships between SE and the prevalence of suppression disorders (permanent suppression or binocular rivalry suppression). Sensitivity analysis and subgroup analysis were used.ResultsThe prevalence of suppression disorders was 30.6%. Multivariate logistic regression analysis revealed a dose–response relationship between SE and the prevalence of suppression disorder (odds ratio [OR]: 1.08, 95% CI: 1.00–1.17, p = 0.044) after adjusting for age, sex, anisometropia, cylindrical anisometropia, division, fusion, best corrected visual acuity (BCVA), FS0.8, FS1.5, and GS. Restricted cubic splines analysis revealed that the odds ratio of suppression disorder increased approximately linearly with the increase in spherical equivalent (P for non-linearity = 0.7633 > 0.05). Subgroup analyses showed that this association persisted in those aged <25 years (OR: 1.15; 95% CI: 1.04 ~ 1.27, p = 0.006), those with normal GS (OR: 1.17, 95% CI, 1.03–1.34, p = 0.020), and those with normal FS0.8 (1.09, 95% CI: 1.01–1.18, p = 0.026). In a sensitivity analysis that categorized myopia into three groups, a statistically significant positive association between high myopia (OR: 1.87, 95% CI: 1.10–3.29, p = 0.025), moderate myopia (OR: 1.75, 95% CI: 1.04–3.03, p = 0.039), and suppression disorder was found after adjustment for covariates.ConclusionMyopia severity independently correlates with suppression disorders, suggesting the need for functional vision screening and personalized myopia correction strategies in high-risk populations. |
| format | Article |
| id | doaj-art-33a21e8d92624d1db8e1f609fd1d6ea5 |
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| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-33a21e8d92624d1db8e1f609fd1d6ea52025-08-20T02:36:02ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-06-011210.3389/fmed.2025.14815411481541The hidden impact of myopia severity on interocular suppression in myopia: a cross-sectional studyYan Luo0Xiyang Yang1Enwei Lin2Min Kong3Wuqiang Luo4Qi Chen5Jin Zeng6Li Yan7Lili Li8Xin Xiao9Xin Xiao10Xin Xiao11Visual Science and Optometry Center, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Ophthalmology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, ChinaVisual Science and Optometry Center, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaVisual Science and Optometry Center, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaVisual Science and Optometry Center, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaVisual Science and Optometry Center, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Ophthalmology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, ChinaNational Engineering Research Center for Healthcare Devices, Guangzhou, ChinaVisual Science and Optometry Center, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaVisual Science and Optometry Center, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaGuangxi Key Laboratory of Eye Health, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Scientific Research, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaObjectiveThis study aimed to investigate the association between spherical equivalent (SE) and interocular suppression in myopic adults, addressing the knowledge gap in functional visual impairments beyond structural changes.MethodsThis hospital-based cross-sectional study included 988 myopic patients (aged 18.0–48.7 years, SE ≥ 0.50D). Grating stereopsis (GS), fine stereopsis at 1.5 m (FS1.5), fine stereopsis at 0.8 m (FS0.8), division, fusion, and interocular suppression were examined via computer-based tasks. Multivariate logistic regression analysis and restricted cubic splines (RCSs) were used to analyze the dose–response relationships between SE and the prevalence of suppression disorders (permanent suppression or binocular rivalry suppression). Sensitivity analysis and subgroup analysis were used.ResultsThe prevalence of suppression disorders was 30.6%. Multivariate logistic regression analysis revealed a dose–response relationship between SE and the prevalence of suppression disorder (odds ratio [OR]: 1.08, 95% CI: 1.00–1.17, p = 0.044) after adjusting for age, sex, anisometropia, cylindrical anisometropia, division, fusion, best corrected visual acuity (BCVA), FS0.8, FS1.5, and GS. Restricted cubic splines analysis revealed that the odds ratio of suppression disorder increased approximately linearly with the increase in spherical equivalent (P for non-linearity = 0.7633 > 0.05). Subgroup analyses showed that this association persisted in those aged <25 years (OR: 1.15; 95% CI: 1.04 ~ 1.27, p = 0.006), those with normal GS (OR: 1.17, 95% CI, 1.03–1.34, p = 0.020), and those with normal FS0.8 (1.09, 95% CI: 1.01–1.18, p = 0.026). In a sensitivity analysis that categorized myopia into three groups, a statistically significant positive association between high myopia (OR: 1.87, 95% CI: 1.10–3.29, p = 0.025), moderate myopia (OR: 1.75, 95% CI: 1.04–3.03, p = 0.039), and suppression disorder was found after adjustment for covariates.ConclusionMyopia severity independently correlates with suppression disorders, suggesting the need for functional vision screening and personalized myopia correction strategies in high-risk populations.https://www.frontiersin.org/articles/10.3389/fmed.2025.1481541/fullmyopiainterocular suppressionspherical equivalent (SE)associationdose–response relationshipcross-sectional study |
| spellingShingle | Yan Luo Xiyang Yang Enwei Lin Min Kong Wuqiang Luo Qi Chen Jin Zeng Li Yan Lili Li Xin Xiao Xin Xiao Xin Xiao The hidden impact of myopia severity on interocular suppression in myopia: a cross-sectional study Frontiers in Medicine myopia interocular suppression spherical equivalent (SE) association dose–response relationship cross-sectional study |
| title | The hidden impact of myopia severity on interocular suppression in myopia: a cross-sectional study |
| title_full | The hidden impact of myopia severity on interocular suppression in myopia: a cross-sectional study |
| title_fullStr | The hidden impact of myopia severity on interocular suppression in myopia: a cross-sectional study |
| title_full_unstemmed | The hidden impact of myopia severity on interocular suppression in myopia: a cross-sectional study |
| title_short | The hidden impact of myopia severity on interocular suppression in myopia: a cross-sectional study |
| title_sort | hidden impact of myopia severity on interocular suppression in myopia a cross sectional study |
| topic | myopia interocular suppression spherical equivalent (SE) association dose–response relationship cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1481541/full |
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