Analgesic and Anti-inflammatory Activities of the Stem Bark of Yellow Flamboyant (<i>Peltophorum pterocarpum</i>)
Peltophorum pterocarpum (family; Fabaceae) is an evergreen perennial crop grown in tropical gardens. Different parts of this tree are being used for the management of many diseases. This study investigated the acute toxicity, analgesic and anti-inflammatory potentials of n-hexane extract of P. pter...
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| Format: | Article |
| Language: | English |
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Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)
2019-08-01
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| Series: | Journal of Applied Sciences and Environmental Management |
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| Online Access: | https://www.Ajol.Info/index.php/jasem/article/view/188782 |
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| author | O.K. Ogbeide C.J. Ogbonnaya E. Asakitikpi D.O. Uyi B.O. Aluge O. Nosakhare W.O. Otahagwa C.A. Ehigie U. Omoruyi O.S. Aifuwa B.O. Gabriel |
| author_facet | O.K. Ogbeide C.J. Ogbonnaya E. Asakitikpi D.O. Uyi B.O. Aluge O. Nosakhare W.O. Otahagwa C.A. Ehigie U. Omoruyi O.S. Aifuwa B.O. Gabriel |
| author_sort | O.K. Ogbeide |
| collection | DOAJ |
| description |
Peltophorum pterocarpum (family; Fabaceae) is an evergreen perennial crop grown in tropical gardens. Different parts of this tree are being used for the management of many diseases. This study investigated the acute toxicity, analgesic and anti-inflammatory potentials of n-hexane extract of P. pterocarpum stem bark. Acute oral toxicity of n-hexane extract of P. pterocarpum stem bark was investigated using standard method. Analgesic activity was investigated by using acetic acid-induced writhing model, using indomethacin as a reference drug. Antiinflammatory activity of n-hexane extract of P. pterocarpum stem bark was investigated by using formalin-induced paw licking model, using aspirin as standard drug. In the acute toxicity study, mortality was observed at 500 and 2500 mg/kg body weight. In the acetic acid induced writhing test, the n-hexane extract of P. pterocarpum (100 and 200 mg/kg body weight) showed a significant reduction in the number of writhing with 55.5 % and 60 % of inhibition respectively. In formalin-induced rat paw oedema test for acute inflammation, the n-hexane extract of P. pterocarpum in 50, 100 and 200 mg/kg body weight showed 26.00 %, 27.89 % and 32.27 % inhibition of oedema respectively after 4hours, which is comparable to that of standard drug-aspirin (33.59 %). These results validated that the extract of P. pterocarpum possesses significant analgesic and anti-inflammatory properties.
Keywords: Peltophorum pterocarpum, acute toxicity, analgesic activity, anti-inflammatory activity
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| format | Article |
| id | doaj-art-339e8a0d91344508bcab0a7e3d1fffce |
| institution | Kabale University |
| issn | 2659-1502 2659-1499 |
| language | English |
| publishDate | 2019-08-01 |
| publisher | Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP) |
| record_format | Article |
| series | Journal of Applied Sciences and Environmental Management |
| spelling | doaj-art-339e8a0d91344508bcab0a7e3d1fffce2025-02-08T19:51:31ZengJoint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)Journal of Applied Sciences and Environmental Management2659-15022659-14992019-08-01237Analgesic and Anti-inflammatory Activities of the Stem Bark of Yellow Flamboyant (<i>Peltophorum pterocarpum</i>)O.K. OgbeideC.J. OgbonnayaE. AsakitikpiD.O. UyiB.O. AlugeO. NosakhareW.O. OtahagwaC.A. EhigieU. OmoruyiO.S. AifuwaB.O. Gabriel Peltophorum pterocarpum (family; Fabaceae) is an evergreen perennial crop grown in tropical gardens. Different parts of this tree are being used for the management of many diseases. This study investigated the acute toxicity, analgesic and anti-inflammatory potentials of n-hexane extract of P. pterocarpum stem bark. Acute oral toxicity of n-hexane extract of P. pterocarpum stem bark was investigated using standard method. Analgesic activity was investigated by using acetic acid-induced writhing model, using indomethacin as a reference drug. Antiinflammatory activity of n-hexane extract of P. pterocarpum stem bark was investigated by using formalin-induced paw licking model, using aspirin as standard drug. In the acute toxicity study, mortality was observed at 500 and 2500 mg/kg body weight. In the acetic acid induced writhing test, the n-hexane extract of P. pterocarpum (100 and 200 mg/kg body weight) showed a significant reduction in the number of writhing with 55.5 % and 60 % of inhibition respectively. In formalin-induced rat paw oedema test for acute inflammation, the n-hexane extract of P. pterocarpum in 50, 100 and 200 mg/kg body weight showed 26.00 %, 27.89 % and 32.27 % inhibition of oedema respectively after 4hours, which is comparable to that of standard drug-aspirin (33.59 %). These results validated that the extract of P. pterocarpum possesses significant analgesic and anti-inflammatory properties. Keywords: Peltophorum pterocarpum, acute toxicity, analgesic activity, anti-inflammatory activity https://www.Ajol.Info/index.php/jasem/article/view/188782Peltophorum pterocarpumacute toxicityanalgesic activityanti-inflammatory activity |
| spellingShingle | O.K. Ogbeide C.J. Ogbonnaya E. Asakitikpi D.O. Uyi B.O. Aluge O. Nosakhare W.O. Otahagwa C.A. Ehigie U. Omoruyi O.S. Aifuwa B.O. Gabriel Analgesic and Anti-inflammatory Activities of the Stem Bark of Yellow Flamboyant (<i>Peltophorum pterocarpum</i>) Journal of Applied Sciences and Environmental Management Peltophorum pterocarpum acute toxicity analgesic activity anti-inflammatory activity |
| title | Analgesic and Anti-inflammatory Activities of the Stem Bark of Yellow Flamboyant (<i>Peltophorum pterocarpum</i>) |
| title_full | Analgesic and Anti-inflammatory Activities of the Stem Bark of Yellow Flamboyant (<i>Peltophorum pterocarpum</i>) |
| title_fullStr | Analgesic and Anti-inflammatory Activities of the Stem Bark of Yellow Flamboyant (<i>Peltophorum pterocarpum</i>) |
| title_full_unstemmed | Analgesic and Anti-inflammatory Activities of the Stem Bark of Yellow Flamboyant (<i>Peltophorum pterocarpum</i>) |
| title_short | Analgesic and Anti-inflammatory Activities of the Stem Bark of Yellow Flamboyant (<i>Peltophorum pterocarpum</i>) |
| title_sort | analgesic and anti inflammatory activities of the stem bark of yellow flamboyant i peltophorum pterocarpum i |
| topic | Peltophorum pterocarpum acute toxicity analgesic activity anti-inflammatory activity |
| url | https://www.Ajol.Info/index.php/jasem/article/view/188782 |
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