Canine organoids: state-of-the-art, translation potential for human medicine and plea for standardization
Organoids have already shown great promise as research tools in human medicine. However, in veterinary medicine, such applications are limited and largely confined to canine organoids. In the Cross Health context, the potential of canine organoids lies in the translation to human diseases, such as c...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2025.1562004/full |
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| author | Kim Verduijn Kim Verduijn Hilde de Rooster Hilde de Rooster Evelyne Meyer Evelyne Meyer Jonas Steenbrugge Jonas Steenbrugge |
| author_facet | Kim Verduijn Kim Verduijn Hilde de Rooster Hilde de Rooster Evelyne Meyer Evelyne Meyer Jonas Steenbrugge Jonas Steenbrugge |
| author_sort | Kim Verduijn |
| collection | DOAJ |
| description | Organoids have already shown great promise as research tools in human medicine. However, in veterinary medicine, such applications are limited and largely confined to canine organoids. In the Cross Health context, the potential of canine organoids lies in the translation to human diseases, such as cancer. This review provides a state-of-the-art, highlights the current challenges, and at first compares the reported culture conditions of canine organoids derived from both non-neoplastic and neoplastic tissue (i.e., tumoroids), identifying substantial gaps and discrepancies in used culture methods. We make a plea for the standardization of canine organoid culture characteristics and increased rigor in parameter reporting, which will ultimately enhance the reproducibility and applicability of canine organoids in both veterinary and human medicine, especially in the oncology field. |
| format | Article |
| id | doaj-art-339d63eccb3740cb97354cbe8048716b |
| institution | DOAJ |
| issn | 2297-1769 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj-art-339d63eccb3740cb97354cbe8048716b2025-08-20T02:56:07ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-05-011210.3389/fvets.2025.15620041562004Canine organoids: state-of-the-art, translation potential for human medicine and plea for standardizationKim Verduijn0Kim Verduijn1Hilde de Rooster2Hilde de Rooster3Evelyne Meyer4Evelyne Meyer5Jonas Steenbrugge6Jonas Steenbrugge7Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, BelgiumCancer Research Institute Ghent (CRIG)-Veterinary Oncology Network (VON), Ghent, BelgiumSmall Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, BelgiumCancer Research Institute Ghent (CRIG)-Veterinary Oncology Network (VON), Ghent, BelgiumCancer Research Institute Ghent (CRIG)-Veterinary Oncology Network (VON), Ghent, BelgiumLaboratory of Biochemistry, Department of Veterinary and Biosciences, Faculty of Veterinary Medicine, Ghent University, Merelbeke, BelgiumCancer Research Institute Ghent (CRIG)-Veterinary Oncology Network (VON), Ghent, BelgiumLaboratory of Biochemistry, Department of Veterinary and Biosciences, Faculty of Veterinary Medicine, Ghent University, Merelbeke, BelgiumOrganoids have already shown great promise as research tools in human medicine. However, in veterinary medicine, such applications are limited and largely confined to canine organoids. In the Cross Health context, the potential of canine organoids lies in the translation to human diseases, such as cancer. This review provides a state-of-the-art, highlights the current challenges, and at first compares the reported culture conditions of canine organoids derived from both non-neoplastic and neoplastic tissue (i.e., tumoroids), identifying substantial gaps and discrepancies in used culture methods. We make a plea for the standardization of canine organoid culture characteristics and increased rigor in parameter reporting, which will ultimately enhance the reproducibility and applicability of canine organoids in both veterinary and human medicine, especially in the oncology field.https://www.frontiersin.org/articles/10.3389/fvets.2025.1562004/fullorganoidtumoroiddogcross healthculture conditionsmethodological rigor |
| spellingShingle | Kim Verduijn Kim Verduijn Hilde de Rooster Hilde de Rooster Evelyne Meyer Evelyne Meyer Jonas Steenbrugge Jonas Steenbrugge Canine organoids: state-of-the-art, translation potential for human medicine and plea for standardization Frontiers in Veterinary Science organoid tumoroid dog cross health culture conditions methodological rigor |
| title | Canine organoids: state-of-the-art, translation potential for human medicine and plea for standardization |
| title_full | Canine organoids: state-of-the-art, translation potential for human medicine and plea for standardization |
| title_fullStr | Canine organoids: state-of-the-art, translation potential for human medicine and plea for standardization |
| title_full_unstemmed | Canine organoids: state-of-the-art, translation potential for human medicine and plea for standardization |
| title_short | Canine organoids: state-of-the-art, translation potential for human medicine and plea for standardization |
| title_sort | canine organoids state of the art translation potential for human medicine and plea for standardization |
| topic | organoid tumoroid dog cross health culture conditions methodological rigor |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2025.1562004/full |
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